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    ADCK2 aarF domain containing kinase 2 [ Homo sapiens ]

    Gene ID: 90956, updated on 11-May-2012
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    Summary

    Official Symbol
    ADCK2provided by HGNC
    Official Full Name
    aarF domain containing kinase 2provided by HGNC
    Primary source
    HGNC:19039
    See related
    Ensembl:ENSG00000133597; HPRD:10631; Vega:OTTHUMG00000157409
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AARF; MGC20727
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    Genomic context

    Location :
    7q34
    Sequence :
    Chromosome: 7; NC_000007.13 (140372953..140394908)
    See ADCK2 in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene makorin ring finger protein 1 Neighboring gene DENN/MADD domain containing 2A Neighboring gene uncharacterized LOC100134713 Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa Neighboring gene v-raf murine sarcoma viral oncogene homolog B1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. Altun M, et al. Chem Biol, 2011 Nov 23. PMID 22118674.
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Hendrickson SL, et al. PLoS One, 2010 Sep 21. PMID 20877624.
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
    4. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Jin J, et al. Curr Biol, 2004 Aug 24. PMID 15324660.
    5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:124782 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124782 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ADCK2 gene: The ADCK2 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    uncharacterized aarF domain-containing protein kinase 2
    Names
    uncharacterized aarF domain-containing protein kinase 2
    putative ubiquinone biosynthesis protein AarF
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052853.3 → NP_443085.2  uncharacterized aarF domain-containing protein kinase 2

      Status: VALIDATED

      Source sequence(s)
      AY302592, BC014107
      Consensus CDS
      CCDS5861.1
      UniProtKB/TrEMBL
      A4D1T6
      UniProtKB/Swiss-Prot
      Q7Z695
      Related
      ENSP00000072869, OTTHUMP00000212102, ENST00000072869, OTTHUMT00000348734
      Conserved Domains (1) summary
      cl09925
      Location:288 – 618
      Blast Score: 337
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      140372953..140394908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      134668921..134690587
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      139711129..139733084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006344.2 AAD43192.1
    genomic AC006452.5 (111421..121504) None
    genomic CH236950.1 EAL24025.1
    genomic CH471070.1 EAW83956.1
      EAW83957.1
    mRNA AF131745.1 None
    mRNA AY302592.1 AAP60021.1
    mRNA BC014107.2 AAH14107.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z695.1 GenPept UniProtKB/Swiss-Prot:Q7Z695
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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    Tools
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      Supplemental Content

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