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EIF1AY eukaryotic translation initiation factor 1A, Y-linked [ Homo sapiens (human) ]

Gene ID: 9086, updated on 9-Nov-2014
Official Symbol
EIF1AYprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 1A, Y-linkedprovided by HGNC
Primary source
HGNC:HGNC:3252
See related
Ensembl:ENSG00000198692; HPRD:02455; MIM:400014; Vega:OTTHUMG00000036544
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
eIF-4C
Summary
This gene is located on the non-recombining region of the Y chromosome. It encodes a protein related to eukaryotic translation initiation factor 1A (EIF1A), which may function in stabilizing the binding of the initiator Met-tRNA to 40S ribosomal subunits. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
See EIF1AY in Epigenomics, MapViewer
Location:
Yq11.223
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) Y NC_000024.10 (20575711..20593154)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (22737597..22755040)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928633 Neighboring gene lysine (K)-specific demethylase 5D pseudogene 1 Neighboring gene family with sequence similarity 8, member A1 pseudogene Neighboring gene transducin (beta)-like 1, Y-linked pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ45762

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation initiation factor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
translational initiation IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
eukaryotic translation initiation factor 1A, Y-chromosomal
Names
eukaryotic translation initiation factor 1A, Y-chromosomal
eIF-1A Y isoform
eukaryotic translation initiation factor 4C
eukaryotic translation initiation factor 1A, Y chromosome

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278612.1NP_001265541.1  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 2

    See proteins identical to NP_001265541.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC007678, AF000987, BG499107, BP331805, DQ786267
    Consensus CDS
    CCDS65368.1
    UniProtKB/TrEMBL
    A6NJH9
    UniProtKB/Swiss-Prot
    O14602
    Conserved Domains (1) summary
    cd05793
    Location:3392
    S1_IF1A; S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation ...
  2. NM_004681.3NP_004672.2  eukaryotic translation initiation factor 1A, Y-chromosomal isoform 1

    See proteins identical to NP_004672.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007678, AF000987, BC005248, BG499107, BP331805
    Consensus CDS
    CCDS14795.1
    UniProtKB/Swiss-Prot
    O14602
    Related
    ENSP00000354722, OTTHUMP00000034700, ENST00000361365, OTTHUMT00000088877
    Conserved Domains (1) summary
    cd05793
    Location:33109
    S1_IF1A; S1_IF1A: Translation initiation factor IF1A, also referred to as eIF1A in eukaryotes and aIF1A in archaea, S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. IF1A is essential for translation ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000156.1 

    Range
    16322372..16339816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000024.10 

    Range
    20575711..20593154
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)