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    CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) [ Homo sapiens ]

    Gene ID: 908, updated on 11-May-2012

    Summary

    Official Symbol
    CCT6Aprovided by HGNC
    Official Full Name
    chaperonin containing TCP1, subunit 6A (zeta 1)provided by HGNC
    Primary source
    HGNC:1620
    See related
    Ensembl:ENSG00000146731; HPRD:00089; MIM:104613; Vega:OTTHUMG00000022842
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta; MGC126214; MGC126215
    Summary
    The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

    Genomic context

    Location :
    7p11.2
    Sequence :
    Chromosome: 7; NC_000007.13 (56119378..56131682)
    See CCT6A in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene glioblastoma amplified sequence Neighboring gene phosphoserine phosphatase Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase, gamma 1 (muscle)

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P40227 Q6EEV6 SUMO4    HPRD  PubMed  
    BioGRID:107346 BioGRID:123842 CTTNBP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:116452 GPN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:109698 IGBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:117369 MOB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:204968 Mapk13    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111507 PPP2CA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111508 PPP2CB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111512 PPP2R2A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111513 PPP2R2B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111514 PPP2R2C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:120946 PPP2R2D    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111523 PPP4C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:111657 PSMA3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:122136 RFWD2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:114011 STK24    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:112674 STRN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:118999 STRN3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:112810 TCP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107346 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Co-purification 
    BioGRID:107346 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    • Homologs of the CCT6A gene: The CCT6A gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, rice, and P.falciparum.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    'de novo' posttranslational protein folding TAS
    Traceable Author Statement
    more info
     
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
     
    protein folding TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    chaperonin-containing T-complex IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    T-complex protein 1 subunit zeta
    Names
    T-complex protein 1 subunit zeta
    histidine transport regulator 3
    T-complex protein 1, zeta subunit
    amino acid transport defect-complementing
    chaperonin containing T-complex subunit 6
    acute morphine dependence related protein 2
    acute morphine dependence-related protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009186.1NP_001009186.1  T-complex protein 1 subunit zeta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).
      Source sequence(s)
      AC092101, AW411253, BI464886, BU540578
      Consensus CDS
      CCDS34640.1
      UniProtKB/TrEMBL
      A6NCD2
      Related
      ENSP00000352019, OTTHUMP00000209314, ENST00000335503, OTTHUMT00000343286
      Conserved Domains (2) summary
      cd03342
      Location:7481
      Blast Score: 1779
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      pfam00118
      Location:30480
      Blast Score: 1038
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family
    2. NM_001762.3NP_001753.1  T-complex protein 1 subunit zeta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC092101, AC092579, AW411253, BI464886
      Consensus CDS
      CCDS5523.1
      UniProtKB/Swiss-Prot
      P40227
      Related
      ENSP00000275603, OTTHUMP00000159736, ENST00000275603, OTTHUMT00000251526
      Conserved Domains (2) summary
      cd03342
      Location:7526
      Blast Score: 2053
      TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
      pfam00118
      Location:30525
      Blast Score: 1230
      Cpn60_TCP1; TCP-1/cpn60 chaperonin family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      56119378..56131682
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      55933178..55945465
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      56123625..56135929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC092101.5 AAS07451.1
    genomic AC092579.3 (111062..118957) None
    genomic CH471140.1 EAX07972.1
      EAX07973.1
      EAX07974.1
    mRNA AB063318.1 BAB61032.1
    mRNA AB209728.1 BAD92965.1
    mRNA AF385084.1 AAK61354.1
    mRNA AK297751.1 BAG60101.1
    mRNA AK298371.1 BAG60610.1
    mRNA AK313819.1 BAG36555.1
    mRNA AK316230.1 BAH14601.1
    mRNA AM295155.1 CAL26601.1
    mRNA AW411253.1 None
    mRNA BC106941.1 None
    mRNA BC106942.1 AAI06943.1
    mRNA BI464886.1 None
    mRNA BU540578.1 None
    mRNA L27706.1 AAA61061.1
    mRNA M94083.1 AAA58676.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40227.3 GenPept UniProtKB/Swiss-Prot:P40227
    Q59ET3 GenPept UniProtKB/TrEMBL:Q59ET3

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