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CCT6A chaperonin containing TCP1 subunit 6A [ Homo sapiens (human) ]

Gene ID: 908, updated on 26-May-2016
Official Symbol
CCT6Aprovided by HGNC
Official Full Name
chaperonin containing TCP1 subunit 6Aprovided by HGNC
Primary source
HGNC:HGNC:1620
See related
Ensembl:ENSG00000146731 HPRD:00089; MIM:104613; Vega:OTTHUMG00000022842
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCT6; Cctz; HTR3; TCPZ; TCP20; MoDP-2; TTCP20; CCT-zeta; CCT-zeta-1; TCP-1-zeta
Summary
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]
Orthologs
Location:
7p11.2
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (56051685..56063989)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (56119378..56131682)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene glioblastoma amplified sequence Neighboring gene phosphoserine phosphatase Neighboring gene small nucleolar RNA, H/ACA box 15 Neighboring gene sulfatase modifying factor 2 Neighboring gene phosphorylase kinase catalytic subunit gamma 1 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 2

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of chaperonin containing TCP1, subunit 6A (CCT6A) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126214, MGC126215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
WD40-repeat domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding involved in protein folding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
chaperonin-containing T-complex IDA
Inferred from Direct Assay
more info
PubMed 
chaperonin-containing T-complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
T-complex protein 1 subunit zeta
Names
T-complex protein 1, zeta subunit
acute morphine dependence related protein 2
acute morphine dependence-related protein 2
amino acid transport defect-complementing
chaperonin containing T-complex subunit 6
chaperonin containing TCP1, subunit 6A (zeta 1)
histidine transport regulator 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009186.1NP_001009186.1  T-complex protein 1 subunit zeta isoform b

    See identical proteins and their annotated locations for NP_001009186.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b).
    Source sequence(s)
    AC092101, AW411253, BI464886, BU540578
    Consensus CDS
    CCDS34640.1
    UniProtKB/Swiss-Prot
    P40227
    Related
    ENSP00000352019, OTTHUMP00000209314, ENST00000335503, OTTHUMT00000343286
    Conserved Domains (2) summary
    cd03342
    Location:7481
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02339
    Location:19479
    thermosome_arch; thermosome, various subunits, archaeal
  2. NM_001762.3NP_001753.1  T-complex protein 1 subunit zeta isoform a

    See identical proteins and their annotated locations for NP_001753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC092101, AC092579, AW411253, BI464886
    Consensus CDS
    CCDS5523.1
    UniProtKB/Swiss-Prot
    P40227
    UniProtKB/TrEMBL
    A0A024RDL1
    Related
    ENSP00000275603, OTTHUMP00000159736, ENST00000275603, OTTHUMT00000251526
    Conserved Domains (2) summary
    cd03342
    Location:7526
    TCP1_zeta; TCP-1 (CTT or eukaryotic type II) chaperonin family, zeta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...
    TIGR02339
    Location:19524
    thermosome_arch; thermosome, various subunits, archaeal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    56051685..56063989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    56122415..56134705
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)