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    MAP3K6 mitogen-activated protein kinase kinase kinase 6 [ Homo sapiens ]

    Gene ID: 9064, updated on 11-May-2012
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    Summary

    Official Symbol
    MAP3K6provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 6provided by HGNC
    Primary source
    HGNC:6858
    Locus tag
    RP11-4K3__A.7
    See related
    Ensembl:ENSG00000142733; HPRD:05126; MIM:604468; Vega:OTTHUMG00000004631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ASK2; MEKK6; MAPKKK6; MGC20114; MGC125653
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. The encoded kinase was identified by its interaction with MAP3K5/ASK, a protein kinase and an activator of c-Jun kinase (MAPK7/JNK) and MAPK14/p38 kinase. This kinase was found to weakly activate MAPK7, but not MAPK1/ERK or MAPK14. An alternatively spliced transcript variant has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p36.11
    Sequence :
    Chromosome: 1; NC_000001.10 (27681670..27693337, complement)
    See MAP3K6 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene transmembrane protein 222 Neighboring gene actin, gamma 1 pseudogene Neighboring gene synaptotagmin-like 1 Neighboring gene ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) Neighboring gene CD164 sialomucin-like 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    5. Network organization of the human autophagy system. Behrends C, et al. Nature, 2010 Jul 1. PMID 20562859.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. regulation of VEGF by MAP3K6 may play a crucial role in both angiogenesis and tumorigenesis.
      Title: Mitogen-activated protein 3 kinase 6 mediates angiogenic and tumorigenic effects via vascular endothelial growth factor expression.
    3. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    4. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
      Title: Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O95382 Q99683 MAP3K5    HPRD  PubMed  
    O95382 O95382 MAP3K6    HPRD  PubMed  
    BioGRID:114524 BioGRID:110381 MAP3K5    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114524 BioGRID:111550 PRKAA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114524 BioGRID:111552 PRKAB2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114524 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • p38 MAPK signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      p38 MAPK signaling pathway, organism-specific biosystem
      p38 MAPK signaling pathway

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    MAP kinase kinase kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    activation of JUN kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    activation of MAPKK activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 6
    Names
    mitogen-activated protein kinase kinase kinase 6
    apoptosis signal regulating kinase 2
    apoptosis signal-regulating kinase 2
    NP_004663.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004672.3 → NP_004663.3  mitogen-activated protein kinase kinase kinase 6

      Status: REVIEWED

      Source sequence(s)
      AB167411, AF100318, AI658745, BF115137
      Consensus CDS
      CCDS299.1
      UniProtKB/Swiss-Prot
      O95382
      Related
      ENSP00000350195, OTTHUMP00000179079, ENST00000357582, OTTHUMT00000277002
      Conserved Domains (3) summary
      smart00220
      Location:653 – 906
      Blast Score: 707
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      pfam13281
      Location:130 – 507
      Blast Score: 1226
      DUF4071; Domain of unknown function (DUF4071)
      cl09925
      Location:639 – 906
      Blast Score: 1346
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      27681670..27693337, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      25937810..25949477, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL663123.1 CAI14778.1
      CAI14780.1
      CAM12869.1
    genomic CH471059.2 EAX07758.1
    mRNA AB167411.1 BAD12485.1
    mRNA AB208805.1 BAD92042.1
    mRNA AF100318.1 AAD05304.1
    mRNA AI582755.1 None
    mRNA AI658745.1 None
    mRNA BC015914.1 AAH15914.1
    mRNA BC109032.2 AAI09033.1
    mRNA BC129950.1 AAI29951.1
    mRNA BC129951.1 AAI29952.1
    mRNA BF115137.1 None
    other-genetic BC169211.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    JE0363 GenPept
    O95382.3 GenPept UniProtKB/Swiss-Prot:O95382
    Q32MQ5 GenPept UniProtKB/TrEMBL:Q32MQ5
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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