STARD13 StAR-related lipid transfer (START) domain containing 13 [Homo sapiens] - Gene

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Summary

Official Symbol: STARD13provided by HGNC
Official Full Name: StAR-related lipid transfer (START) domain containing 13provided by HGNC
Primary source: HGNC:19164
Locus tag: RP11-81F11.1
See related: Ensembl:ENSG00000133121; HPRD:11607; MIM:609866; Vega:OTTHUMG00000016708
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DLC2; GT650; ARHGAP37
Summary: This gene encodes a protein which contains an N-terminal sterile alpha motif (SAM) for protein-protein interactions, followed by an ATP/GTP-binding motif, a GTPase-activating protein (GAP) domain, and a C-terminal STAR-related lipid transfer (START) domain. It may be involved in regulation of cytoskeletal reorganization, cell proliferation, and cell motility, and acts as a tumor suppressor in hepatoma cells. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

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Genomic context

Location :: 13q12-q13

Sequence :: Chromosome: 13; NC_000013.10 (33677272..33859901, complement)

See STARD13 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DLC2 inhibits the activity of Raf-1-ERK1/2-p70S6K via its RhoGAP function, resulting in the suppression of cell growth.
Title: Deleted in liver cancer 2 suppresses cell growth via the regulation of the Raf-1-ERK1/2-p70S6K signalling pathway.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study of intracranial aneurysm identifies three new risk loci.
underexpression is associated with poor prognosis in patients with hepatocellular carcinoma
Title: Underexpression of deleted in liver cancer 2 (DLC2) is associated with overexpression of RhoA and poor prognosis in hepatocellular carcinoma.
has GAP activity specific for RhoA and Cdc42; inhibits the Rho mediated assembly of actin stress fibers in cultured cells and is underexpressed in hepatocellular carcinoma tissues
Title: Deleted in liver cancer (DLC) 2 encodes a RhoGAP protein with growth suppressor function and is underexpressed in hepatocellular carcinoma.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study of intracranial aneurysm identifies three new risk loci.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_821074.1	NP_001694.1	BAI2	BIND	PubMed	STARD13 (RhoGAP) interacts with BAI2.
NP_821074.1	BAA20796.1	EPB41L1	BIND	PubMed	STARD13 (RhoGAP) interacts with EPB41L1 (KIAA0338).
NP_821074.1	NP_000850.1	HMGCR	BIND	PubMed	STARD13 (RhoGAP) interacts with HMGCR (HMG CoA reductase).
NP_821074.1	NP_031381.2	HSP90AB1	BIND	PubMed	STARD13 (RhoGAP) interacts with HSPCB.
NP_821074.1	NP_002213.1	ITPR1	BIND	PubMed	STARD13 (RhoGAP) interacts with ITPR1.
NP_821074.1	AAK49332.1	KIF1B	BIND	PubMed	STARD13 (RhoGAP) interacts with KIF1B.
NP_821074.1		SMARCD3	BIND	PubMed	STARD13 (RhoGAP) interacts with an unspecified isoform of SMARCD3 (SWI/SNF).
NP_821074.1	NP_006015.4	TAX1BP1	BIND	PubMed	STARD13 (RhoGAP) interacts with TAX1BP1 (Tax1BP).
NP_821074.1	NP_006073.2	TUBA1B	BIND	PubMed	STARD13 (RhoGAP) interacts with K-ALPHA-1 (alpha-tubulin).
Q9Y3M8	O60241	BAI2	HPRD	PubMed
Q9Y3M8	Q9H4G0	EPB41L1	HPRD	PubMed
Q9Y3M8	P04035	HMGCR	HPRD	PubMed
Q9Y3M8	P08238	HSP90AB1	HPRD	PubMed
Q9Y3M8	Q14643	ITPR1	HPRD	PubMed
Q9Y3M8	O60333	KIF1B	HPRD	PubMed
Q9Y3M8	Q15797	SMAD1	HPRD	PubMed
Q9Y3M8	Q86VP1	TAX1BP1	HPRD	PubMed
Q9Y3M8	P68366	TUBA4A	HPRD	PubMed
BioGRID:124744	BioGRID:107052	BAI2	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:112763	CNTN2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:124744	BioGRID:108350	EPB41L1	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:109399	HMGCR	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:109913	ITPR1	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:116723	KIF1B	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:112488	SMARCD3	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:114405	TAX1BP1	BioGRID	PubMed	Two-hybrid
BioGRID:124744	BioGRID:113603	TUBA1A	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid

Function	Evidence Code	Pubs
GTPase activator activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
regulation of small GTPase mediated signal transduction	TAS Traceable Author Statement more info
signal transduction	IEA Inferred from Electronic Annotation more info
small GTPase mediated signal transduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
intracellular	IEA Inferred from Electronic Annotation more info
lipid particle	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
mitochondrial membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: stAR-related lipid transfer protein 13

Names: stAR-related lipid transfer protein 13; DLC-2; 46H23.2; deleted in liver cancer 2 protein; Rho GTPase activating protein on chromosome 13q12

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029752.1 RefSeqGene

Range

5001..187630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001243466.1 → NP_001230395.1 stAR-related lipid transfer protein 13 isoform 5

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in a shorter isoform (5) with distinct N- and C- termini compared to isoform 1.

Source sequence(s)

AK308453, BC046563

UniProtKB/Swiss-Prot

Q9Y3M8

Conserved Domains (3) summary

cd09592
Location:49 – 112
Blast Score: 348

SAM_DLC2; SAM domain of STARD13-like subfamily

pfam07647
Location:52 – 112
Blast Score: 111

SAM_2; SAM domain (Sterile alpha motif)

cl02570
Location:649 – 686
Blast Score: 179

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001243474.1 → NP_001230403.1 stAR-related lipid transfer protein 13 isoform 6

Status: REVIEWED

Description

Transcript Variant: This variant (6) contains an alternate 5' terminal exon, and differs at the 3' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (6) with a shorter N-terminus, and a distinct C-terminus compared to isoform 1.

Source sequence(s)

AK091804, AK308453, BC046563, BP233049

UniProtKB/TrEMBL

B3KRK6

UniProtKB/Swiss-Prot

Q9Y3M8

Conserved Domains (1) summary

cl02570
Location:539 – 642
Blast Score: 501

RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
NM_001243476.1 → NP_001230405.1 stAR-related lipid transfer protein 13 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains additional exons at the 5' end compared to variant 1. This results in translation initiation from an in-frame upstream start codon, and a shorter isoform (4) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AA256386, AK308453, AY082589, BX647695, CB163673, DA312208

UniProtKB/Swiss-Prot

Q9Y3M8

Conserved Domains (4) summary

cd04375
Location:622 – 839
Blast Score: 865

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cd08909
Location:865 – 1069
Blast Score: 1120

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09592
Location:22 – 85
Blast Score: 351

SAM_DLC2; SAM domain of STARD13-like subfamily

pfam07647
Location:25 – 85
Blast Score: 109

SAM_2; SAM domain (Sterile alpha motif)
NM_052851.2 → NP_443083.1 stAR-related lipid transfer protein 13 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG, and an isoform (3, also known as DLC2gamma) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AA256386, AL049801, AY082590, AY082591, AY366448, BP233049, CB163673

Consensus CDS

CCDS9350.1

UniProtKB/TrEMBL

B2R789

UniProtKB/Swiss-Prot

Q9Y3M8

Related

ENSP00000382300, OTTHUMP00000205446, ENST00000399365, OTTHUMT00000044437

Conserved Domains (2) summary

cd04375
Location:539 – 756
Blast Score: 866

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cd08909
Location:782 – 986
Blast Score: 1120

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain
NM_178006.3 → NP_821074.1 stAR-related lipid transfer protein 13 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1, also known as DLC2alpha).

Source sequence(s)

AA256386, AY082589, AY082590, AY366448, CB163673, DC402824

Consensus CDS

CCDS9348.1

UniProtKB/Swiss-Prot

Q9Y3M8

Related

ENSP00000338785, OTTHUMP00000178559, ENST00000336934, OTTHUMT00000276118

Conserved Domains (4) summary

cd04375
Location:657 – 874
Blast Score: 863

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cd08909
Location:900 – 1104
Blast Score: 1121

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09592
Location:57 – 120
Blast Score: 351

SAM_DLC2; SAM domain of STARD13-like subfamily

pfam07647
Location:60 – 120
Blast Score: 109

SAM_2; SAM domain (Sterile alpha motif)
NM_178007.2 → NP_821075.1 stAR-related lipid transfer protein 13 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon compared to variant 1. This results in a shorter isoform (2, also known as DLC2beta) with a distinct N-terminus compared to isoform 1.

Source sequence(s)

AA256386, AY082590, AY366448, CB163673

Consensus CDS

CCDS9349.1

UniProtKB/Swiss-Prot

Q9Y3M8

Related

ENSP00000255486, OTTHUMP00000178560, ENST00000255486, OTTHUMT00000044439

Conserved Domains (4) summary

cd04375
Location:649 – 866
Blast Score: 866

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cd08909
Location:892 – 1096
Blast Score: 1118

START_STARD13-like; C-terminal lipid-binding START domain of mammalian STARD13 and related proteins, which also have an N-terminal Rho GTPase-activating protein (RhoGAP) domain

cd09592
Location:49 – 112
Blast Score: 350

SAM_DLC2; SAM domain of STARD13-like subfamily

pfam07647
Location:52 – 112
Blast Score: 109

SAM_2; SAM domain (Sterile alpha motif)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p5 Primary Assembly

Range

33677272..33859901, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

14489080..14671691, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_178008.1: Suppressed sequence

Description

NM_178008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL139187.19	CAM23625.1
		CAM23626.1
		CAX15160.1
genomic	AL139187.19	CAM23625.1
		CAM23626.1
		CAX15160.1
genomic	AL627232.6	CAM17900.1
genomic	CH471075.1	EAX08527.1
		EAX08528.1
		EAX08529.1
		EAX08530.1
		EAX08531.1
genomic	Z84483.1	CAC94774.1
mRNA	AA256386.1	None
mRNA	AK091804.1	BAG52418.1
mRNA	AK094704.1	BAG52916.1
mRNA	AK095114.1	BAG52987.1
mRNA	AK308430.1	None
mRNA	AK308453.1	None
mRNA	AK312888.1	BAG35736.1
mRNA	AL049801.1	CAB42562.1
mRNA	AY082589.1	AAL91648.1
mRNA	AY082590.1	AAL91649.1
mRNA	AY082591.1	AAL91650.1
mRNA	AY082592.1	AAL91651.1
mRNA	AY366448.1	AAQ72791.1
mRNA	BC046563.1	AAH46563.1
mRNA	BP233049.1	None
mRNA	BX641149.1	CAE46065.1
mRNA	BX647695.1	CAI46026.1
mRNA	CB163673.1	None
mRNA	DA312208.1	None
mRNA	DC402824.1	None

Protein Accession	Links
Protein Accession	GenePept Link	UniProtKB Link
Q6MZG8	GenPept	UniProtKB/TrEMBL:Q6MZG8
Q86XT0	GenPept	UniProtKB/TrEMBL:Q86XT0
Q9Y3M8.2	GenPept	UniProtKB/Swiss-Prot:Q9Y3M8