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PRC1 protein regulator of cytokinesis 1 [ Homo sapiens (human) ]

Gene ID: 9055, updated on 19-May-2016
Official Symbol
PRC1provided by HGNC
Official Full Name
protein regulator of cytokinesis 1provided by HGNC
Primary source
HGNC:HGNC:9341
See related
Ensembl:ENSG00000198901 HPRD:17899; MIM:603484; Vega:OTTHUMG00000171685
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ASE1
Summary
This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a substrate of several cyclin-dependent kinases (CDKs). It is necessary for polarizing parallel microtubules and concentrating the factors responsible for contractile ring assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Orthologs
Location:
15q26.1
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (90966038..90994651, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (91509268..91537881, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene unc-45 myosin chaperone A Neighboring gene HD domain containing 3 Neighboring gene RCC1 domain containing 1 Neighboring gene PRC1 antisense RNA 1 Neighboring gene VPS33B, late endosome and lysosome associated Neighboring gene uncharacterized LOC105370970 Neighboring gene uncharacterized LOC101926911

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1.
NHGRI GWA Catalog
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.
NHGRI GWA Catalog
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis.
NHGRI GWA Catalog
  • RHO GTPase Effectors, organism-specific biosystem (from REACTOME)
    RHO GTPase Effectors, organism-specific biosystemRHO GTPases regulate cell behaviour by activating a number of downstream effectors that regulate cytoskeletal organization, intracellular trafficking and transcription (reviewed by Sahai and Marshall...
  • RHO GTPases activate CIT, organism-specific biosystem (from REACTOME)
    RHO GTPases activate CIT, organism-specific biosystemCitron kinase (CIT) or citron RHO-interacting kinase (CRIK) shares similarities with ROCK kinases. Like ROCK, it consists of a serine/threonine kinase domain, a coiled-coil region, a RHO-binding doma...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Rho GTPases, organism-specific biosystem (from REACTOME)
    Signaling by Rho GTPases, organism-specific biosystemThe Rho family of small guanine nucleotide binding proteins is one of five generally recognized branches of the Ras superfamily. Like most Ras superfamily members, typical Rho proteins function as bi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC1671, MGC3669

Gene Ontology Provided by GOA

Function Evidence Code Pubs
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
kinesin binding IPI
Inferred from Physical Interaction
more info
PubMed 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokinesis IDA
Inferred from Direct Assay
more info
PubMed 
microtubule bundle formation IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle elongation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
spindle microtubule TAS
Traceable Author Statement
more info
PubMed 
spindle pole IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
protein regulator of cytokinesis 1
Names
PRC1
anaphase spindle elongation 1 homolog
protein regulating cytokinesis 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050647.1 RefSeqGene

    Range
    5001..33614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267580.1NP_001254509.1  protein regulator of cytokinesis 1 isoform 4

    See identical proteins and their annotated locations for NP_001254509.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region, and uses and alternate splice site and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC068831, AK297117, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS45353.2
    UniProtKB/Swiss-Prot
    O43663
    Related
    ENSP00000409549, OTTHUMP00000246706, ENST00000442656, OTTHUMT00000414762
    Conserved Domains (2) summary
    pfam03999
    Location:34523
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:219370
    Glyco_hydro_77; 4-alpha-glucanotransferase
  2. NM_003981.3NP_003972.1  protein regulator of cytokinesis 1 isoform 1

    See identical proteins and their annotated locations for NP_003972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF044588, BC003138, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS32334.1
    UniProtKB/Swiss-Prot
    O43663
    UniProtKB/TrEMBL
    A0A024RC67
    Related
    ENSP00000377793, OTTHUMP00000246702, ENST00000394249, OTTHUMT00000414757
    Conserved Domains (2) summary
    pfam03999
    Location:37615
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  3. NM_199413.2NP_955445.1  protein regulator of cytokinesis 1 isoform 2

    See identical proteins and their annotated locations for NP_955445.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AC068831, AK312600, BX647317, DA655494, DW423775
    Consensus CDS
    CCDS45352.1
    Related
    ENSP00000354679, OTTHUMP00000246704, ENST00000361188, OTTHUMT00000414760
    Conserved Domains (2) summary
    pfam03999
    Location:37601
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    90966038..90994651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522192.1XP_011520494.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37499
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:141304
    Glyco_hydro_77; 4-alpha-glucanotransferase
  2. XM_011522190.1XP_011520492.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37549
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:203354
    Glyco_hydro_77; 4-alpha-glucanotransferase
  3. XM_011522189.1XP_011520491.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37569
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  4. XM_006720760.1XP_006720823.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37560
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  5. XM_005254987.1XP_005255044.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37564
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  6. XM_006720759.1XP_006720822.1  

    See identical proteins and their annotated locations for XP_006720822.1

    Conserved Domains (2) summary
    pfam03999
    Location:37563
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  7. XM_011522188.1XP_011520490.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37583
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  8. XM_011522187.1XP_011520489.1  

    Conserved Domains (2) summary
    pfam03999
    Location:37606
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase
  9. XM_011522191.1XP_011520493.1  

    See identical proteins and their annotated locations for XP_011520493.1

    Conserved Domains (2) summary
    pfam03999
    Location:37563
    MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
    cl00711
    Location:260411
    Glyco_hydro_77; 4-alpha-glucanotransferase

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    91350870..91379451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199414.1: Suppressed sequence

    Description
    NM_199414.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.