These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
mRNA and Protein(s)
-
NM_003958.3 → NP_003949.1 E3 ubiquitin-protein ligase RNF8 isoform 1
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) represents the most abundant transcript and encodes the longer isoform (1).
- Source sequence(s)
-
AB014546, BE327572, DA064222
- Consensus CDS
-
CCDS4834.1
- UniProtKB/Swiss-Prot
-
O76064
- Related
- ENSP00000362578, OTTHUMP00000016323, ENST00000373479, OTTHUMT00000040403
- Conserved Domains (3) summary
-
- cd00060
Location:17 – 111
Blast Score: 161
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
- cd00162
Location:402 – 444
Blast Score: 132
- RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
- pfam13923
Location:399 – 442
Blast Score: 138
- zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
-
NM_183078.2 → NP_898901.1 E3 ubiquitin-protein ligase RNF8 isoform 2
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) lacks an exon within the coding region, which leads to a translation frameshift, as compared to variant 1. The resulting isoform (2) contains a distinct and shorter C-terminus, as compared to isoform 1.
- Source sequence(s)
-
AB014546, BC007517, BE327572, BM979512, DA064222
- Consensus CDS
-
CCDS4833.1
- UniProtKB/Swiss-Prot
-
O76064
- Related
- ENSP00000418879, OTTHUMP00000216659, ENST00000469731, OTTHUMT00000357593
- Conserved Domains (1) summary
-
- cd00060
Location:17 – 111
Blast Score: 163
- FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
RNA
-
NR_046399.1 RNA Sequence
- Description
- Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region which results in a frameshift, compared to variant 1, and which renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this variant is represented as non-protein coding.
- Source sequence(s)
-
AB014546, AK298319, BE327572, DA064222
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000006.11 Reference GRCh37.p5 Primary Assembly
- Range
- 37321748..37362514
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000138.1 Alternate HuRef
- Range
- 37040684..37081344
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)