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BRSK2 BR serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 9024, updated on 26-May-2016
Official Symbol
BRSK2provided by HGNC
Official Full Name
BR serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:11405
See related
Ensembl:ENSG00000174672 MIM:609236; Vega:OTTHUMG00000167089
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SAD1; SADA; STK29; PEN11B; C11orf7
Orthologs
Location:
11p15.5
Exon count:
27
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (1389899..1462689)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1411129..1483919)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene TOLLIP antisense RNA 1 (head to head) Neighboring gene uncharacterized LOC105376513 Neighboring gene uncharacterized LOC105376516 Neighboring gene uncharacterized LOC105376515 Neighboring gene uncharacterized LOC105376514 Neighboring gene MOB kinase activator 2 Neighboring gene putative uncharacterized protein C11orf81 Neighboring gene dual specificity phosphatase 8

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ41362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase binding IDA
Inferred from Direct Assay
more info
PubMed 
ATPase regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
ERAD pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
establishment of cell polarity ISS
Inferred from Sequence or Structural Similarity
more info
 
exocytosis IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of ATPase activity NAS
Non-traceable Author Statement
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of retrograde protein transport, ER to cytosol IC
Inferred by Curator
more info
PubMed 
regulation of retrograde protein transport, ER to cytosol NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine/threonine-protein kinase BRSK2
Names
BR serine/threonine-protein kinase 2
brain-selective kinase 2
brain-specific serine/threonine-protein kinase 2
protein kinase SAD1B
serine/threonine-protein kinase 29
serine/threonine-protein kinase SAD-A
testicular tissue protein Li 30
NP_001243556.1
NP_001243558.1
NP_001243559.1
NP_001269147.1
NP_003948.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256627.1NP_001243556.1  serine/threonine-protein kinase BRSK2 isoform 1

    See identical proteins and their annotated locations for NP_001243556.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC091196, AC136297, AF533879, AK131534
    Consensus CDS
    CCDS58107.1
    UniProtKB/Swiss-Prot
    Q8IWQ3
    Related
    ENSP00000432000, OTTHUMP00000235107, ENST00000528841, OTTHUMT00000393033
    Conserved Domains (3) summary
    smart00220
    Location:19269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:297350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:17270
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  2. NM_001256629.1NP_001243558.1  serine/threonine-protein kinase BRSK2 isoform 3

    See identical proteins and their annotated locations for NP_001243558.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC091196, AC136297, AF533877, AK131534
    Consensus CDS
    CCDS58106.1
    UniProtKB/Swiss-Prot
    Q8IWQ3
    UniProtKB/TrEMBL
    A0A024RCE9
    Related
    ENSP00000431152, OTTHUMP00000235108, ENST00000531197, OTTHUMT00000393034
    Conserved Domains (3) summary
    smart00220
    Location:19269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:297350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:17270
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  3. NM_001256630.1NP_001243559.1  serine/threonine-protein kinase BRSK2 isoform 4

    See identical proteins and their annotated locations for NP_001243559.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC091196, AK131534
    Consensus CDS
    CCDS58108.1
    UniProtKB/Swiss-Prot
    Q8IWQ3
    Related
    ENSP00000371614, OTTHUMP00000235113, ENST00000382179, OTTHUMT00000393039
    Conserved Domains (3) summary
    smart00220
    Location:77315
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:343396
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:62316
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  4. NM_001282218.1NP_001269147.1  serine/threonine-protein kinase BRSK2 isoform 5

    See identical proteins and their annotated locations for NP_001269147.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in both UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC091196, AK122851, AK297211
    Consensus CDS
    CCDS60696.1
    UniProtKB/Swiss-Prot
    Q8IWQ3
    UniProtKB/TrEMBL
    B4DLY3
    Related
    ENSP00000433235, OTTHUMP00000235112, ENST00000528710, OTTHUMT00000393038
    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  5. NM_003957.3NP_003948.2  serine/threonine-protein kinase BRSK2 isoform 2

    See identical proteins and their annotated locations for NP_003948.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC091196, AC136297, AY166857, DA059153
    Consensus CDS
    CCDS41590.1
    UniProtKB/Swiss-Prot
    Q8IWQ3
    Related
    ENSP00000310697, OTTHUMP00000235105, ENST00000308219, OTTHUMT00000393031
    Conserved Domains (3) summary
    smart00220
    Location:19269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:297350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:17270
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

RNA

  1. NR_046331.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains two alternate exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC091196, AC136297, AF533880, AK131534

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    1389899..1462689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718374.1XP_006718437.1  

    Conserved Domains (3) summary
    smart00220
    Location:19269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:297350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:17270
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  2. XM_005253218.2XP_005253275.1  

    Conserved Domains (3) summary
    smart00220
    Location:19269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:297350
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:17270
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  3. XM_011520464.1XP_011518766.1  

    See identical proteins and their annotated locations for XP_011518766.1

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  4. XM_006718376.1XP_006718439.1  

    See identical proteins and their annotated locations for XP_006718439.1

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  5. XM_011520460.1XP_011518762.1  

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  6. XM_011520463.1XP_011518765.1  

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  7. XM_011520461.1XP_011518763.1  

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  8. XM_011520462.1XP_011518764.1  

    Conserved Domains (3) summary
    smart00220
    Location:2209
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:237290
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cd14081
    Location:1210
    STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
  9. XM_011520465.1XP_011518767.1  

    Conserved Domains (3) summary
    smart00220
    Location:5186
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14340
    Location:214267
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
    cl21453
    Location:9187
    PKc_like; Protein Kinases, catalytic domain
  10. XM_005253220.2XP_005253277.1  

    Conserved Domains (1) summary
    cd14340
    Location:145
    UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins

RNA

  1. XR_242831.2 RNA Sequence

  2. XR_930923.1 RNA Sequence

  3. XR_930925.1 RNA Sequence

  4. XR_930926.1 RNA Sequence

  5. XR_930924.1 RNA Sequence

  6. XR_930927.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    1410344..1482831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)