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TSPAN18 tetraspanin 18 [ Homo sapiens (human) ]

Gene ID: 90139, updated on 8-Aug-2016
Official Symbol
TSPAN18provided by HGNC
Official Full Name
tetraspanin 18provided by HGNC
Primary source
HGNC:HGNC:20660
See related
Ensembl:ENSG00000157570 HPRD:17435; Vega:OTTHUMG00000163883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSPAN
Orthologs
Location:
11p11.2
Exon count:
12
Annotation release Status Assembly Chr Location
108 current GRCh38.p7 (GCF_000001405.33) 11 NC_000011.10 (44727148..44932427)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (44748731..44953978)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L34 pseudogene 22 Neighboring gene uncharacterized LOC105376647 Neighboring gene tumor protein p53 inducible protein 11 Neighboring gene uncharacterized LOC105376649 Neighboring gene uncharacterized LOC221122 Neighboring gene uncharacterized LOC105376650

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat FITC-labeled Tat 47-59 peptide downregulates gene expression of tetraspanin 18 (TSPAN18) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14609

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
tetraspanin-18
Names
tspan-18

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130783.4NP_570139.3  tetraspanin-18

    See identical proteins and their annotated locations for NP_570139.3

    Status: VALIDATED

    Source sequence(s)
    AC092733, AK075547, AY358087, BF110241, DA067480, DA603407, DA734054
    Consensus CDS
    CCDS7910.1
    UniProtKB/Swiss-Prot
    Q96SJ8
    Related
    ENSP00000339820, ENST00000340160
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8247
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p7 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p7 Primary Assembly

    Range
    44727148..44932427
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017018530.1XP_016874019.1  

  2. XM_017018531.1XP_016874020.1  

  3. XM_011520459.2XP_011518761.1  

    See identical proteins and their annotated locations for XP_011518761.1

    UniProtKB/Swiss-Prot
    Q96SJ8
    Related
    ENSP00000429993, OTTHUMP00000225273, ENST00000520358, OTTHUMT00000376197
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8247
    Tetraspannin; Tetraspanin family
  4. XM_005253217.3XP_005253274.1  

    See identical proteins and their annotated locations for XP_005253274.1

    Conserved Domains (2) summary
    cd03156
    Location:115228
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18257
    Tetraspannin; Tetraspanin family
  5. XM_006718373.3XP_006718436.1  

    See identical proteins and their annotated locations for XP_006718436.1

    UniProtKB/Swiss-Prot
    Q96SJ8
    Conserved Domains (2) summary
    cd03156
    Location:105218
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:8247
    Tetraspannin; Tetraspanin family
  6. XM_006718372.3XP_006718435.1  

    See identical proteins and their annotated locations for XP_006718435.1

    Conserved Domains (2) summary
    cd03156
    Location:115228
    uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:18257
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    44785142..44953229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031730.1: Suppressed sequence

    Description
    NM_001031730.1: This RefSeq was permanently suppressed because the transcript is 5' partial, and its full-length nature is unknown.