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    PHLDB2 pleckstrin homology-like domain, family B, member 2 [ Homo sapiens ]

    Gene ID: 90102, updated on 11-May-2012
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    Summary

    Official Symbol
    PHLDB2provided by HGNC
    Official Full Name
    pleckstrin homology-like domain, family B, member 2provided by HGNC
    Primary source
    HGNC:29573
    See related
    Ensembl:ENSG00000144824; HPRD:06611; MIM:610298; Vega:OTTHUMG00000159282
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LL5b; LL5beta; FLJ21791; DKFZp434G227; DKFZp313O2433; DKFZp686J05113
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    Genomic context

    Location :
    3q13.2
    Sequence :
    Chromosome: 3; NC_000003.11 (111451327..111695364)
    See PHLDB2 in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene CD96 molecule Neighboring gene 5'-nucleotidase, cytosolic III pseudogene Neighboring gene zinc finger, BED-type containing 2 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 2 Neighboring gene VGSA5840 Neighboring gene abhydrolase domain containing 10 Neighboring gene transgelin 3

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    2. Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta. Hotta A, et al. J Cell Biol, 2010 May 31. PMID 20513769.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2. Takabayashi T, et al. J Biol Chem, 2010 May 21. PMID 20236936.
    5. Common genetic variation and performance on standardized cognitive tests. Cirulli ET, et al. Eur J Hum Genet, 2010 Jul. PMID 20125193.

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Signaling from laminin-integrin associations in epithelial cells attaches microtubule plus ends to the epithelial basal cell cortex via PHLDB1 and PHLDB2.
      Title: Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
      Title: LL5beta directs the translocation of filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2.
    4. LL5beta and ELKS can form a PIP3-regulated cortical platform to which CLASPs attach distal microtubule ends.
      Title: CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Common genetic variation and performance on standardized cognitive tests.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q86SQ0 Q14315 FLNC    HPRD  PubMed  
    Q86SQ0 P61981 YWHAG    HPRD  PubMed  
    BioGRID:124661 BioGRID:108607 FLNC    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:124661 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124661 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: PLCXD2

    Homology

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    intermediate filament cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    pleckstrin homology-like domain family B member 2
    Names
    pleckstrin homology-like domain family B member 2
    LL5 beta
    protein LL5-beta
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134437.1 → NP_001127909.1  pleckstrin homology-like domain family B member 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC060225, AF506820, AW264132, CA310697, CR749654, DA447763
      Consensus CDS
      CCDS46885.1
      UniProtKB/Swiss-Prot
      Q86SQ0
      Related
      ENSP00000377500, OTTHUMP00000214662, ENST00000393923, OTTHUMT00000354338
      Conserved Domains (2) summary
      COG1196
      Location:601 – 800
      Blast Score: 120
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      cl00273
      Location:1130 – 1225
      Blast Score: 137
      PH-like; Pleckstrin homology-like domain

    2. NM_001134438.1 → NP_001127910.1  pleckstrin homology-like domain family B member 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC060225, AK315050, AW264132, DA438817
      Consensus CDS
      CCDS46886.1
      UniProtKB/Swiss-Prot
      Q86SQ0
      Related
      ENSP00000405405, OTTHUMP00000214661, ENST00000431670, OTTHUMT00000354337
      Conserved Domains (2) summary
      cd00176
      Location:601 – 790
      Blast Score: 94
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl00273
      Location:1146 – 1241
      Blast Score: 136
      PH-like; Pleckstrin homology-like domain

    3. NM_001134439.1 → NP_001127911.1  pleckstrin homology-like domain family B member 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AB209903, AC060225, AW264132, DA272187
      Consensus CDS
      CCDS46886.1
      UniProtKB/Swiss-Prot
      Q86SQ0
      Related
      ENSP00000377502, OTTHUMP00000214668, ENST00000393925, OTTHUMT00000354345
      Conserved Domains (2) summary
      cd00176
      Location:601 – 790
      Blast Score: 94
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl00273
      Location:1146 – 1241
      Blast Score: 136
      PH-like; Pleckstrin homology-like domain

    4. NM_145753.2 → NP_665696.1  pleckstrin homology-like domain family B member 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC060225, AK315050, AW264132, BC069194, DA438817
      Consensus CDS
      CCDS2962.1
      UniProtKB/Swiss-Prot
      Q86SQ0
      Related
      ENSP00000405292, ENST00000412622
      Conserved Domains (2) summary
      COG1196
      Location:574 – 773
      Blast Score: 121
      Smc; Chromosome segregation ATPases [Cell division and chromosome partitioning]
      cl00273
      Location:1103 – 1198
      Blast Score: 137
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      111451327..111695364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      108826722..109070708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC055748.21 None
    genomic AC060225.12 (36751..129278) None
    genomic AC117509.9 None
    genomic CH471052.2 EAW79690.1
      EAW79691.1
      EAW79692.1
    mRNA AB209903.1 BAD93140.1
    mRNA AF506820.1 AAM33634.1
    mRNA AJ496194.1 CAD42711.1
    mRNA AK025444.1 None
    mRNA AK027862.1 None
    mRNA AK092996.1 BAC04014.1
    mRNA AK096151.1 BAC04713.1
    mRNA AK125555.1 BAC86200.1
    mRNA AK296841.1 BAG59408.1
    mRNA AK307491.1 None
    mRNA AK315050.1 None
    mRNA AL137663.1 CAH56386.1
    mRNA AL832205.1 CAH10396.1
    mRNA AL832476.1 CAH10400.1
    mRNA AL833135.1 CAH56216.3
    mRNA AW264132.1 None
    mRNA BC022383.2 None
    mRNA BC031000.1 AAH31000.1
    mRNA BC038806.1 AAH38806.1
    mRNA BC069194.1 AAH69194.1
    mRNA BC142678.1 AAI42679.1
    mRNA BC150210.1 AAI50211.1
    mRNA BX647615.1 None
    mRNA CA310697.1 None
    mRNA CR749654.1 CAH18447.1
    mRNA DA272187.1 None
    mRNA DA438817.1 None
    mRNA DA447763.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q658P8 GenPept UniProtKB/TrEMBL:Q658P8
    Q659D2 GenPept UniProtKB/TrEMBL:Q659D2
    Q69YN5 GenPept UniProtKB/TrEMBL:Q69YN5
    Q69YR3 GenPept UniProtKB/TrEMBL:Q69YR3
    Q6ZUM0 GenPept UniProtKB/TrEMBL:Q6ZUM0
    Q86SQ0.2 GenPept UniProtKB/Swiss-Prot:Q86SQ0
    Q8IXY4 GenPept UniProtKB/TrEMBL:Q8IXY4
    Q8NEI7 GenPept UniProtKB/TrEMBL:Q8NEI7
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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