CCNG1 cyclin G1 [Homo sapiens] - Gene

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Summary

Official Symbol: CCNG1provided by HGNC
Official Full Name: cyclin G1provided by HGNC
Primary source: HGNC:1592
See related: Ensembl:ENSG00000113328; HPRD:03345; MIM:601578; Vega:OTTHUMG00000130380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCNG
Summary: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 5q32-q34

Sequence :: Chromosome: 5; NC_000005.9 (162864577..162872022)

See CCNG1 in Epigenomics, MapViewer

Chromosome 5 - NC_000005.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
Title: Loss of microRNA 122 expression in patients with hepatitis B enhances hepatitis B virus replication through cyclin G(1) -modulated P53 activity.
Low expression of P27(kip1) and the high expression of cyclin G in patients acute leukemia may have some correlation with genesis and development of the disease.
Title: [Expression of P27(kip1) and cyclin G in patients with acute leukemia and its correlation].
Observational study of gene-disease association. (HuGE Navigator)
Title: Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.
Results show that in patients resected for HCC, lower miR-122 levels were associated with a shorter TTR, whereas higher cyclin G1 expression was related to a lower survival, suggesting that miR-122 might represent an effective molecular target for HCC.
Title: MiR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells.
The B'alpha1 subunit of the serine/threonine protein phosphatase 2A, which binds to cyclin G1, can stabilize cyclin G1 under unstressed conditions and upon DNA damage, as well as inhibit the ability of cyclin G1 to be ubiquitinated.
Title: Lysine-independent turnover of cyclin G1 can be stabilized by B'alpha subunits of protein phosphatase 2A.
the cyclin box has a role in the proteasome-mediated degradation of cyclin G1
Title: A role for the cyclin box in the ubiquitin-mediated degradation of cyclin G1.
Cdk5 activation in cells that overexpress cyclin G1 leads to c-Myc phosphorylation on Ser-62, which is responsible for cyclin G1-mediated transcriptional activation of cyclin B1.
Title: Cdk5-mediated phosphorylation of c-Myc on Ser-62 is essential in transcriptional activation of cyclin B1 by cyclin G1.
Review of cyclin D1 and cyclin G and CDK acitivty and their roles in cancer pathogenesis, and their proteosomal degradation pathways as targets for cancer therapy
Title: Cyclin degradation for cancer therapy and chemoprevention.
does not increase significantly during colorectal carcinogenesis and during later metastasis to lymph nodes.
Title: Cyclin B1, unlike cyclin G1, increases significantly during colorectal carcinogenesis and during later metastasis to lymph nodes.
cyclin G1 is a target of miR-122a in human hepatocellular carcinoma
Title: Cyclin G1 is a target of miR-122a, a microRNA frequently down-regulated in human hepatocellular carcinoma.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P51959	Q00535	CDK5	HPRD	PubMed
P51959	Q8N726	CDKN2A	HPRD	PubMed
P51959	P00403	COX2	HPRD	PubMed
P51959	O14976	GAK	HPRD	PubMed
P51959	Q00987	MDM2	HPRD	PubMed
P51959	Protein phosphatase 2A, catalytic subunit, alpha isoform	PPP2CA	HPRD	PubMed
P51959	Q15257	PPP2R4	HPRD	PubMed
P51959	P04637	TP53	HPRD	PubMed
BioGRID:107340	BioGRID:107463	CDKN2A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107340	BioGRID:108853	GAK	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107340	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107340	BioGRID:111516	PPP2R4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:107340	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107340	BioGRID:113014	TP73	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info
protein domain specific binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
brain development	IEA Inferred from Electronic Annotation more info
cell cycle	IEA Inferred from Electronic Annotation more info
cell division	IEA Inferred from Electronic Annotation more info
cell growth	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle G2/M transition DNA damage checkpoint	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
regulation of cyclin-dependent protein kinase activity	TAS Traceable Author Statement more info	PubMed
response to organic nitrogen	IEA Inferred from Electronic Annotation more info
syncytium formation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
dendrite	IEA Inferred from Electronic Annotation more info
neuronal cell body	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: cyclin-G1

Names: cyclin-G1; cyclin-G

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_004060.3 → NP_004051.1 cyclin-G1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC000196, BM479568, BX644635

Consensus CDS

CCDS4360.1

UniProtKB/Swiss-Prot

P51959

Related

ENSP00000344635, OTTHUMP00000160918, ENST00000340828, OTTHUMT00000252750

Conserved Domains (1) summary

cd00043
Location:59 – 142
Blast Score: 135

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_199246.1 → NP_954854.1 cyclin-G1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

BC000196, BM479568

Consensus CDS

CCDS4360.1

UniProtKB/Swiss-Prot

P51959

Related

ENSP00000377506, ENST00000393929

Conserved Domains (1) summary

cd00043
Location:59 – 142
Blast Score: 135

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000005.9 Reference GRCh37.p5 Primary Assembly

Range

162864577..162872022

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000137.1 Alternate HuRef

Range

157964260..157971705

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC112205.2 (7296..14741)	None
genomic	AY791292.1	AAV40836.1
genomic	CH471062.2	EAW61528.1
		EAW61529.1
		EAW61530.1
genomic	D86077.1	BAA13007.1
mRNA	AK297190.1	BAG59679.1
mRNA	AK312913.1	BAG35759.1
mRNA	AK316234.1	BAH14605.1
mRNA	BC000196.1	AAH00196.1
mRNA	BC007093.2	AAH07093.1
mRNA	BM479568.1	None
mRNA	BT007134.1	AAP35798.1
mRNA	BX538035.1	CAD97979.1
mRNA	BX644635.1	None
mRNA	D78341.1	BAA11353.1
mRNA	L49504.1	AAC41977.1
mRNA	U47413.1	AAC50688.1
mRNA	U53328.1	AAB03903.1
mRNA	X77794.1	CAA54821.1
other-genetic	DQ893765.2	ABM84691.1
other-genetic	EU176176.1	ABW03627.1