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CDKL2 cyclin dependent kinase like 2 [ Homo sapiens (human) ]

Gene ID: 8999, updated on 8-May-2016
Official Symbol
CDKL2provided by HGNC
Official Full Name
cyclin dependent kinase like 2provided by HGNC
Primary source
HGNC:HGNC:1782
See related
Ensembl:ENSG00000138769 HPRD:16021; MIM:603442
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P56; KKIAMRE
Summary
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
Orthologs
Location:
4q21.1
Exon count:
14
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (75576494..75630537, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76501704..76555721, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ring finger and CHY zinc finger domain containing 1 Neighboring gene THAP domain containing 6 Neighboring gene chromosome 4 open reading frame 26 Neighboring gene G3BP stress granule assembly factor 2 Neighboring gene USO1 vesicle transport factor Neighboring gene uncharacterized LOC105377284

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein targeting to mitochondrion IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
sex differentiation TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
cyclin-dependent kinase-like 2
Names
CDC2-related kinase
cyclin-dependent kinase-like 2 (CDC2-related kinase)
p56 KKIAMRE protein kinase
protein kinase p56 KKIAMRE
serine/threonine protein kinase KKIAMRE
serine/threonine-protein kinase KKIAMRE
testicular tissue protein Li 35
NP_003939.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003948.3NP_003939.1  cyclin-dependent kinase-like 2

    See identical proteins and their annotated locations for NP_003939.1

    Status: REVIEWED

    Source sequence(s)
    AA813092, AC096759, DB448184, U35146
    Consensus CDS
    CCDS3570.1
    UniProtKB/Swiss-Prot
    Q92772
    Related
    ENSP00000412365, OTTHUMP00000160596, ENST00000429927, OTTHUMT00000252409
    Conserved Domains (2) summary
    smart00220
    Location:4287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2287
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    75576494..75630537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263335.2XP_005263392.1  

    UniProtKB/TrEMBL
    J3KNE8
    Related
    ENSP00000306340, OTTHUMP00000219250, ENST00000307465, OTTHUMT00000362891
    Conserved Domains (2) summary
    smart00220
    Location:4287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2287
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  2. XM_006714406.2XP_006714469.1  

    Conserved Domains (2) summary
    smart00220
    Location:4287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2287
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
  3. XM_006714407.2XP_006714470.1  

    Conserved Domains (2) summary
    smart00220
    Location:4287
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07846
    Location:2287
    STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    76478463..76532392 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)