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    CDKL2 cyclin-dependent kinase-like 2 (CDC2-related kinase) [ Homo sapiens ]

    Gene ID: 8999, updated on 11-May-2012
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    Summary

    Official Symbol
    CDKL2provided by HGNC
    Official Full Name
    cyclin-dependent kinase-like 2 (CDC2-related kinase)provided by HGNC
    Primary source
    HGNC:1782
    See related
    Ensembl:ENSG00000138769; HPRD:16021; MIM:603442; Vega:OTTHUMG00000130103
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P56; KKIAMRE
    Summary
    This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the cytoplasm, with lower levels in the nucleus. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    4q21.1
    Sequence :
    Chromosome: 4; NC_000004.11 (76501704..76555721, complement)
    See CDKL2 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene THAP domain containing 6 Neighboring gene chromosome 4 open reading frame 26 Neighboring gene GTPase activating protein (SH3 domain) binding protein 2 Neighboring gene USO1 vesicle docking protein homolog (yeast)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    2. Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck). Marracci GH, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631599.
    3. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Sarkar SN, et al. Nat Struct Mol Biol, 2004 Nov. PMID 15502848.
    4. Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation. Tao J, et al. Am J Hum Genet, 2004 Dec. PMID 15499549.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. We hypothesized that LA might induce dissociation of p56(Lck) from CD4, thus leading to its downmodulation.
      Title: Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000004.9 NP_001562.1 IRF3    BIND  PubMed IRF-3 interacts with the P56 promoter. 
    Q92772 P22681 CBL    HPRD  PubMed  
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    sex differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    cyclin-dependent kinase-like 2
    Names
    cyclin-dependent kinase-like 2
    CDC2-related kinase
    p56 KKIAMRE protein kinase
    protein kinase p56 KKIAMRE
    serine/threonine protein kinase KKIAMRE
    serine/threonine-protein kinase KKIAMRE
    NP_003939.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003948.3 → NP_003939.1  cyclin-dependent kinase-like 2

      Status: REVIEWED

      Source sequence(s)
      AA813092, AC096759, DB448184, U35146
      Consensus CDS
      CCDS3570.1
      UniProtKB/Swiss-Prot
      Q92772
      Related
      ENSP00000412365, OTTHUMP00000160596, ENST00000429927, OTTHUMT00000252409
      Conserved Domains (2) summary
      cd07846
      Location:2 – 287
      Blast Score: 1584
      STKc_CDKL2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3
      smart00220
      Location:4 – 287
      Blast Score: 742
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      76501704..76555721, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      72248538..72302292, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC096759.3 (184395..194362) None
    genomic AC104828.4 None
    genomic AC108939.3 None
    genomic CH471057.1 EAX05740.1
      EAX05741.1
    mRNA AA813092.1 None
    mRNA AK294866.1 BAG57969.1
    mRNA AK309127.1 None
    mRNA AK312490.1 BAG35392.1
    mRNA BC017417.1 None
    mRNA BC093646.1 AAH93646.1
    mRNA BC093981.1 AAH93981.1
    mRNA DB448184.1 None
    mRNA U35146.1 AAC50918.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92772.1 GenPept UniProtKB/Swiss-Prot:Q92772
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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