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    KLC4 kinesin light chain 4 [ Homo sapiens ]

    Gene ID: 89953, updated on 19-May-2012
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    Summary

    Official Symbol
    KLC4provided by HGNC
    Official Full Name
    kinesin light chain 4provided by HGNC
    Primary source
    HGNC:21624
    See related
    Ensembl:ENSG00000137171; HPRD:13932; Vega:OTTHUMG00000014720
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KNSL8; bA387M24.3; MGC111777
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    Genomic context

    Location :
    6p21.1
    Sequence :
    Chromosome: 6; NC_000006.11 (43027372..43042833)
    See KLC4 in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene cullin 7 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene serum response factor (c-fos serum response element-binding transcription factor)

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Insight into the molecular mechanism of the multitasking kinesin-8 motor. Peters C, et al. EMBO J, 2010 Oct 20. PMID 20818331.
    2. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    3. Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. Jeronimo C, et al. Mol Cell, 2007 Jul 20. PMID 17643375.
    4. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. Beausoleil SA, et al. Nat Biotechnol, 2006 Oct. PMID 16964243.

    See all (12) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data reveal aspects of the molecular mechanism of kinesin-8 motors that contribute to their unique dual motile and depolymerising functions, which are adapted to control microtubule length.
      Title: Insight into the molecular mechanism of the multitasking kinesin-8 motor.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9NSK0 P38432 COIL    HPRD  PubMed  
    Q9NSK0 P63104 YWHAZ    HPRD  PubMed  
    BioGRID:124648 BioGRID:247522 Nedd4    BioGRID  PubMed Biochemical Activity 
    BioGRID:124648 BioGRID:112781 TCEA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124648 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124648 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:124648 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • Salmonella infection, organism-specific biosystem (from KEGG)
      Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
    • Salmonella infection, conserved biosystem (from KEGG)
      Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    kinesin light chain 4
    Names
    kinesin light chain 4
    KLC 4
    kinesin-like 8
    kinesin-like protein 8
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138343.2 → NP_612352.1  kinesin light chain 4 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different splice site in the 3' coding region that results in an early stop codon, compared to variant 1. The predicted protein (isoform c) has a shorter N-terminus when compared to isoform a. This transcript is supported by multiple ESTs, but the experimental existence of isoform c needs to be confirmed.
      Source sequence(s)
      AK056393, BC012357
      Consensus CDS
      CCDS47429.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000410358, OTTHUMP00000216971, ENST00000458460, OTTHUMT00000358143
      Conserved Domains (3) summary
      cd00189
      Location:212 – 285
      Blast Score: 92
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam09311
      Location:79 – 252
      Blast Score: 410
      Rab5-bind; Rabaptin-like protein
      pfam13374
      Location:252 – 293
      Blast Score: 113
      TPR_10; Tetratricopeptide repeat

    2. NM_201521.1 → NP_958929.1  kinesin light chain 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) occurs the most frequently. It encodes isoform a.
      Source sequence(s)
      AK056393, AL162078, CA450484
      Consensus CDS
      CCDS4883.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000340221, OTTHUMP00000216974, ENST00000347162, OTTHUMT00000040578
      Conserved Domains (3) summary
      cd00189
      Location:305 – 406
      Blast Score: 108
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam09311
      Location:79 – 252
      Blast Score: 464
      Rab5-bind; Rabaptin-like protein
      pfam13424
      Location:249 – 327
      Blast Score: 150
      TPR_12; Tetratricopeptide repeat

    3. NM_201522.1 → NP_958930.1  kinesin light chain 4 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different alternate 5' UTR exon, compared to variant 1. It encodes the same isoform (a) as variant 1.
      Source sequence(s)
      AK094102, AK127894, BQ688778, CA450484
      Consensus CDS
      CCDS4883.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000377622, ENST00000394058
      Conserved Domains (3) summary
      cd00189
      Location:305 – 406
      Blast Score: 108
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam09311
      Location:79 – 252
      Blast Score: 464
      Rab5-bind; Rabaptin-like protein
      pfam13424
      Location:249 – 327
      Blast Score: 150
      TPR_12; Tetratricopeptide repeat

    4. NM_201523.1 → NP_958931.1  kinesin light chain 4 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate exon for its 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct and longer N-terminus when compared to isoform a.
      Source sequence(s)
      AK094102, AK127894, CA450484
      Consensus CDS
      CCDS4882.1
      UniProtKB/Swiss-Prot
      Q9NSK0
      Related
      ENSP00000259708, OTTHUMP00000216972, ENST00000259708, OTTHUMT00000358144
      Conserved Domains (3) summary
      cd00189
      Location:323 – 424
      Blast Score: 111
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam09311
      Location:97 – 270
      Blast Score: 469
      Rab5-bind; Rabaptin-like protein
      pfam13424
      Location:267 – 345
      Blast Score: 152
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      43027372..43042833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      42744364..42759826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL355385.15 CAI13781.1
    genomic CH471081.1 EAX04146.1
      EAX04147.1
      EAX04148.1
      EAX04149.1
    mRNA AK055293.1 BAG51496.1
    mRNA AK056393.1 BAG51695.1
    mRNA AK094102.1 BAG52815.1
    mRNA AK127018.1 BAC86788.1
    mRNA AK127894.1 BAC87179.1
    mRNA AK297433.1 BAG59861.1
    mRNA AL162078.1 CAB82411.1
    mRNA BC012357.1 AAH12357.1
    mRNA BC080637.1 AAH80637.1
    mRNA BC103727.1 AAI03728.1
    mRNA BQ688778.1 None
    mRNA BX640717.1 CAE45836.1
    mRNA CA450484.1 None
    other-genetic DQ892231.2 ABM83157.1
    other-genetic DQ895432.2 ABM86358.1
    other-genetic EU831763.1 ACE87281.1
    other-genetic EU831841.1 ACE86600.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NSK0.3 GenPept UniProtKB/Swiss-Prot:Q9NSK0
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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