TRPA1 transient receptor potential cation channel, subfamily A, member 1 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: TRPA1provided by HGNC
Official Full Name: transient receptor potential cation channel, subfamily A, member 1provided by HGNC
Primary source: HGNC:497
See related: Ensembl:ENSG00000104321; HPRD:09208; MIM:604775; Vega:OTTHUMG00000164516
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ANKTM1
Summary: The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 8q13

Sequence :: Chromosome: 8; NC_000008.10 (72933486..72987819, complement)

See TRPA1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Agonists of TRPV1 and TRPA1 induced MUC5B release in the human nasal airways in vivo.
Title: TRPV1 and TRPA1 stimulation induces MUC5B secretion in the human nasal airway in vivo.
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli
Title: Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli.
Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells.
Title: Expression of functional TRPA1 receptor on human lung fibroblast and epithelial cells.
Human dental pulp fibroblasts express TRPA1 at the molecular, protein, and functional levels, indicating a possible role for fibroblasts in mediating cold responses in human teeth.
Title: Human dental pulp fibroblasts express the "cold-sensing" transient receptor potential channels TRPA1 and TRPM8.
Findings provide important insight into the basic fundamental properties and function of TRPA1 channels in general and hTRPA1 channel in particular.
Title: The pore properties of human nociceptor channel TRPA1 evaluated in single channel recordings.
upregulating endogenous expression of TRPA1, that TRPA1 activation may be an additional trigger for co-expressed calcium-dependent ion channels such as TRPM5, and that TRPM5 may amplify responses to TRPA1 ligands
Title: Overexpression of human transient receptor potential M5 upregulates endogenous human transient receptor potential A1 in a stable HEK cell line.
TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.
Title: TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids.
Introduction of a Met268Pro point mutation into mTRPA1 changed the effect of caffeine from activation to suppression.
Title: The Met268Pro mutation of mouse TRPA1 changes the effect of caffeine from activation to suppression.
identify basic residues in the C-terminus that are strongly involved in TRPA1 voltage and chemical sensitivity, and some of them may represent possible interaction sites for negatively charged molecules that are generally considered to modulate TRPA1.
Title: The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association of somatoform disorder symptoms with genetic variants potentially involved in the modulation of nociception.

Submit: New GeneRIF Correction See all (40)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:114471	BioGRID:107920	CYLD		BioGRID	PubMed	Affinity Capture-Western
BioGRID:114471	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
calcium channel activity	IEA Inferred from Electronic Annotation more info
channel activity	IEA Inferred from Electronic Annotation more info
ion channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
detection of chemical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
detection of mechanical stimulus involved in sensory perception of pain	IEA Inferred from Electronic Annotation more info
ion transport	TAS Traceable Author Statement more info	PubMed
response to cold	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info
response to pain	IEA Inferred from Electronic Annotation more info
response to stimulus	IEA Inferred from Electronic Annotation more info
thermoception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane	IEA Inferred from Electronic Annotation more info
stereocilium bundle	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: transient receptor potential cation channel subfamily A member 1

Names: transient receptor potential cation channel subfamily A member 1; transformation-sensitive protein p120; ankyrin-like with transmembrane domains 1; ankyrin-like with transmembrane domains protein 1

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007332.2 → NP_015628.2 transient receptor potential cation channel subfamily A member 1

Status: REVIEWED

Source sequence(s)

AC016057, AC022867

Consensus CDS

CCDS34908.1

UniProtKB/Swiss-Prot

O75762

Related

ENSP00000262209, OTTHUMP00000226879, ENST00000262209, OTTHUMT00000379079

Conserved Domains (4) summary

cd00204
Location:95 – 218
Blast Score: 280

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam08016
Location:762 – 957
Blast Score: 105

PKD_channel; Polycystin cation channel

pfam12796
Location:486 – 577
Blast Score: 209

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:66 – 118
Blast Score: 106

Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

72933486..72987819, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

68428222..68482529, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC016057.6 (126240..168791)	None
genomic	AC022867.10 (185148..196930)	None
genomic	CH471068.1	EAW86986.1
mRNA	AK307942.1	None
mRNA	Y10601.1	CAA71610.1
other-genetic	BC148423.1	AAI48424.1
other-genetic	BC153003.1	AAI53004.1