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    TPD52L3 tumor protein D52-like 3 [ Homo sapiens ]

    Gene ID: 89882, updated on 11-May-2012
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    Summary

    Official Symbol
    TPD52L3provided by HGNC
    Official Full Name
    tumor protein D52-like 3provided by HGNC
    Primary source
    HGNC:23382
    See related
    Ensembl:ENSG00000170777; HPRD:14864; Vega:OTTHUMG00000019518
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hD55; NYDSP25; MGC26757; MGC45374
    Summary
    This gene encodes a member of the tumor protein D52-like family of proteins. These proteins are characterized by an N-terminal coiled-coil motif that is used to form homo- and heteromeric complexes with other tumor protein D52-like proteins. The encoded protein may play a role in spermatogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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    Genomic context

    Location :
    9p24.1
    Sequence :
    Chromosome: 9; NC_000009.11 (6328349..6331900)
    See TPD52L3 in Epigenomics, MapViewer

    Chromosome 9 - NC_000009.11Genomic Context describing neighboring genes Neighboring gene interleukin 33 Neighboring gene selenoprotein T pseudogene Neighboring gene ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase Neighboring gene chromosome 9 open reading frame 38 Neighboring gene glycine dehydrogenase (decarboxylating) Neighboring gene ribosomal protein L23a pseudogene 57

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. Cao Q, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16631610.
    2. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514.
    3. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556.
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039.
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Tumor protein D52-like 3 P08651 NFIC    HPRD  PubMed  
    Tumor protein D52-like 3 P55327 TPD52    HPRD  PubMed  
    Tumor protein D52-like 3 Q16890 TPD52L1    HPRD  PubMed  
    Tumor protein D52-like 3 O43399 TPD52L2    HPRD  PubMed  
    Tumor protein D52-like 3 Tumor protein D52-like 3 TPD52L3    HPRD  PubMed  
    BioGRID:124633 BioGRID:110854 NFIC    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

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    General protein information

    Preferred Names
    tumor protein D55
    Names
    tumor protein D55
    protein kinase NYD-SP25
    testis development protein NYD-SP25
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001874.2 → NP_001001874.1  tumor protein D55 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which has a shorter and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL133480, BC033792, BP369721
      Consensus CDS
      CCDS34984.1
      UniProtKB/Swiss-Prot
      Q96J77
      Related
      ENSP00000318665, OTTHUMP00000021043, ENST00000314556, OTTHUMT00000051659
      Conserved Domains (1) summary
      pfam04201
      Location:2 – 130
      Blast Score: 336
      TPD52; Tumour protein D52 family

    2. NM_001001875.3 → NP_001001875.1  tumor protein D55 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an internal segment, as compared to variant 1. It encodes isoform 3 which has a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AL133480, BC017589, BP369721, DB507802
      Consensus CDS
      CCDS34985.1
      UniProtKB/Swiss-Prot
      Q96J77
      Related
      ENSP00000370836, OTTHUMP00000021044, ENST00000381428, OTTHUMT00000051660
      Conserved Domains (1) summary
      pfam04201
      Location:2 – 123
      Blast Score: 325
      TPD52; Tumour protein D52 family

    3. NM_033516.5 → NP_277051.3  tumor protein D55 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK057479, AL133480, BP369721
      Consensus CDS
      CCDS34986.1
      UniProtKB/Swiss-Prot
      Q96J77
      Related
      ENSP00000341677, OTTHUMP00000021042, ENST00000344545, OTTHUMT00000051658
      Conserved Domains (1) summary
      pfam04201
      Location:2 – 138
      Blast Score: 350
      TPD52; Tumour protein D52 family

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000009.11 Reference GRCh37.p5 Primary Assembly

      Range
      6328349..6331900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000141.1 Alternate HuRef

      Range
      6283854..6287404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL133480.9 CAI13289.1
      CAI13290.1
      CAI13291.1
    genomic CH471071.2 EAW58745.1
      EAW58746.1
      EAW58747.1
    genomic HC007194.1 CBH19402.1
    genomic HC044679.1 CBH30669.1
    mRNA AI032390.1 None
    mRNA AK057479.1 BAB71505.1
    mRNA AY032877.1 AAK66820.1
    mRNA BC017589.2 AAH17589.1
    mRNA BC033792.1 AAH33792.1
    mRNA BC042113.1 AAH42113.1
    mRNA BI463769.1 None
    mRNA BP369721.1 None
    mRNA DB507802.1 None
    other-genetic JF432545.1 ADZ15762.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96J77.2 GenPept UniProtKB/Swiss-Prot:Q96J77
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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