Format

Send to:

Choose Destination

PLCZ1 phospholipase C zeta 1 [ Homo sapiens (human) ]

Gene ID: 89869, updated on 26-May-2016
Official Symbol
PLCZ1provided by HGNC
Official Full Name
phospholipase C zeta 1provided by HGNC
Primary source
HGNC:HGNC:19218
See related
Ensembl:ENSG00000139151 HPRD:06996; MIM:608075; Vega:OTTHUMG00000168937
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PLCzeta; NYD-SP27; PLC-zeta-1
Summary
The protein encoded by this gene is a member of the phosphoinositide-specific phospholipase C family. Members in this family, classified into six isotypes that are tissue- and organ-specific, hydrolyze phosphatidylinositol 4,5-bisphosphate just before the phosphate group to yield diacylglycerol and inositol 1,4,5-trisphosphate. This protein localizes to the acrosome in spermatozoa and elicits Ca(2+) oscillations and egg activation during fertilization that leads to early embryonic development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Orthologs
Location:
12p12.3
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (18641990..18738059, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (18836110..18891020, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma Neighboring gene Nedd4 family interacting protein 1 pseudogene 1 Neighboring gene uncharacterized LOC105369680 Neighboring gene zinc finger with KRAB and SCAN domains 7 pseudogene 1 Neighboring gene uncharacterized LOC105369679 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 9 Neighboring gene uncharacterized LOC102724227 Neighboring gene capping actin protein of muscle Z-line alpha subunit 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC149685

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phospholipase C activity TAS
Traceable Author Statement
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
calcium ion transport IEA
Inferred from Electronic Annotation
more info
 
egg activation IEA
Inferred from Electronic Annotation
more info
 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Names
PI-phospholipase C zeta 1
PLC-zeta-1
PLCZ1
phosphoinositide phospholipase C-zeta-1
phospholipase C, zeta 1
testicular tissue protein Li 145
testis-development related NYD-SP27
NP_149114.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033123.3NP_149114.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

    See identical proteins and their annotated locations for NP_149114.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AF532185, DB038101, HY197954
    Consensus CDS
    CCDS8680.1
    UniProtKB/Swiss-Prot
    Q86YW0
    Related
    ENSP00000266505, OTTHUMP00000239780, ENST00000266505, OTTHUMT00000401667
    Conserved Domains (5) summary
    pfam09279
    Location:72154
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:481606
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:154452
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:71607
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:1868
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RNA

  1. NR_073075.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK314516, DB038101, HY197954
    Related
    ENST00000318197, OTTHUMT00000401729

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    18641990..18738059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520875.1XP_011519177.1  

    Conserved Domains (5) summary
    pfam09279
    Location:98180
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:548671
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:180519
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:97669
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:4494
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  2. XM_011520872.1XP_011519174.1  

    Conserved Domains (5) summary
    pfam09279
    Location:98180
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:548672
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:180519
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:97669
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:4494
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  3. XM_011520876.1XP_011519178.1  

    See identical proteins and their annotated locations for XP_011519178.1

    Conserved Domains (3) summary
    pfam09279
    Location:150
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:418541
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
  4. XM_011520881.1XP_011519183.1  

    Conserved Domains (2) summary
    cd00275
    Location:285408
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1256
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  5. XM_011520873.1XP_011519175.1  

    Conserved Domains (5) summary
    pfam09279
    Location:72154
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:522645
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:154493
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:71643
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:1868
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  6. XM_011520884.1XP_011519186.1  

    Conserved Domains (2) summary
    cd00275
    Location:222345
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1193
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  7. XM_005253523.2XP_005253580.2  

    See identical proteins and their annotated locations for XP_005253580.2

    Conserved Domains (3) summary
    pfam09279
    Location:150
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:418541
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
  8. XM_011520878.1XP_011519180.1  

    See identical proteins and their annotated locations for XP_011519180.1

    Conserved Domains (3) summary
    cd00275
    Location:394517
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:26365
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl08538
    Location:126
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  9. XM_011520877.1XP_011519179.1  

    See identical proteins and their annotated locations for XP_011519179.1

    Conserved Domains (3) summary
    pfam09279
    Location:150
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:418541
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:50389
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
  10. XM_011520879.1XP_011519181.1  

    See identical proteins and their annotated locations for XP_011519181.1

    Conserved Domains (3) summary
    cd00275
    Location:394517
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:26365
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    cl08538
    Location:126
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  11. XM_011520880.1XP_011519182.1  

    Conserved Domains (2) summary
    cd00275
    Location:334457
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:3305
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  12. XM_011520882.1XP_011519184.1  

    Related
    ENSP00000445880, OTTHUMP00000239954, ENST00000538330, OTTHUMT00000401666
    Conserved Domains (2) summary
    cd00275
    Location:263386
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:1234
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  13. XM_005253519.2XP_005253576.1  

    Conserved Domains (5) summary
    pfam09279
    Location:72154
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:522647
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:154493
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:71648
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:1868
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
  14. XM_011520883.1XP_011519185.1  

    See identical proteins and their annotated locations for XP_011519185.1

    UniProtKB/Swiss-Prot
    Q86YW0
    Related
    ENSP00000445026, OTTHUMP00000239781, ENST00000539875, OTTHUMT00000401668
    Conserved Domains (2) summary
    cd00275
    Location:288413
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cl14615
    Location:35259
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
  15. XM_011520874.1XP_011519176.1  

    Conserved Domains (5) summary
    pfam09279
    Location:98180
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd00275
    Location:548673
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08595
    Location:180519
    PI-PLCc_zeta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-zeta
    PLN02952
    Location:97674
    PLN02952; phosphoinositide phospholipase C
    cl08538
    Location:4494
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RNA

  1. XR_931330.1 RNA Sequence

  2. XR_931332.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    18801167..18856044 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)