KLHL6 kelch-like 6 (Drosophila) [Homo sapiens] - Gene

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Summary

Official Symbol: KLHL6provided by HGNC
Official Full Name: kelch-like 6 (Drosophila)provided by HGNC
Primary source: HGNC:18653
See related: Ensembl:ENSG00000172578; HPRD:10035; MIM:614214; Vega:OTTHUMG00000148673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLJ00029

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Genomic context

Location :: 3q27.3

Sequence :: Chromosome: 3; NC_000003.11 (183205319..183273499, complement)

See KLHL6 in Epigenomics, MapViewer

Chromosome 3 - NC_000003.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

characterization of two genes expressed in centroblasts of human tonsils: deltex (Drosophila) homolog 1 (DTX1), which is related to the Notch pathway and a new Kelch-like protein, KLHL6
Title: Specific over-expression of deltex and a new Kelch-like protein in human germinal center B cells.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:124622	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Process	Evidence Code	Pubs
B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
germinal center formation	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: kelch-like protein 6

Names: kelch-like protein 6; kelch-like protein KLHL6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130446.2 → NP_569713.2 kelch-like protein 6

Status: VALIDATED

Source sequence(s)

AC092960, AK097125, BC032348, BP284594

Consensus CDS

CCDS3245.2

UniProtKB/Swiss-Prot

Q8WZ60

Related

ENSP00000341342, OTTHUMP00000192902, ENST00000341319, OTTHUMT00000309024

Conserved Domains (4) summary

PHA03098
Location:319 – 529
Blast Score: 225

PHA03098; kelch-like protein; Provisional

cl06652
Location:174 – 274
Blast Score: 335

BACK; BTB And C-terminal Kelch

cl02518
Location:62 – 165
Blast Score: 261

BTB; BTB/POZ domain

cl02701
Location:411 – 454
Blast Score: 145

Kelch_3; Galactose oxidase, central domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000003.11 Reference GRCh37.p5 Primary Assembly

Range

183205319..183273499, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000135.1 Alternate HuRef

Range

180611770..180679998, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC069211.15 (48790..105487)	None
genomic	AC092960.3	None
genomic	CH471052.2	EAW78323.1
		EAW78324.1
		EAW78325.1
		EAW78326.1
mRNA	AF441792.1	AAL35594.1
mRNA	AK024439.2	BAB15729.2
mRNA	AK097125.1	BAC04957.1
mRNA	AK314473.1	BAG37078.1
mRNA	AL833667.1	None
mRNA	BC032348.1	AAH32348.1
mRNA	BP284594.1	None
mRNA	BX648370.1	None
other-genetic	DQ894788.2	ABM85714.1
other-genetic	EU176275.1	ABW03726.1