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Sfrp4 secreted frizzled-related protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 89803, updated on 17-May-2016
Official Symbol
Sfrp4provided by RGD
Official Full Name
secreted frizzled-related protein 4provided by RGD
Primary source
RGD:621075
See related
Ensembl:ENSRNOG00000054957
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
Wnt binding protein involved in modulation of Wnt signaling [RGD, Feb 2006]
Annotation information
Annotation category: partial on reference assembly
Orthologs
Location:
17q11
Exon count:
6
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (47383983..47394065, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (56095166..56105248)

Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546469 Neighboring gene NME/NM23 family member 8 Neighboring gene ependymin related 1 Neighboring gene hypothetical LOC100361770

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
  • Wnt Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Wnt-protein binding IEA
Inferred from Electronic Annotation
more info
 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
decidualization IEP
Inferred from Expression Pattern
more info
PubMed 
female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
mammary gland involution IEP
Inferred from Expression Pattern
more info
PubMed 
mitophagy in response to mitochondrial depolarization IEA
Inferred from Electronic Annotation
more info
 
mitophagy in response to mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of sodium-dependent phosphate transport IEA
Inferred from Electronic Annotation
more info
 
negative regulation of sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
phosphate ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of epidermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of keratinocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to peptide hormone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
secreted frizzled-related protein 4
Names
DDC-4 protein
FRP
frizzled related protein
frizzled-related protein
sFRP-4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053544.1NP_445996.1  secreted frizzled-related protein 4 precursor

    See identical proteins and their annotated locations for NP_445996.1

    Status: PROVISIONAL

    Source sequence(s)
    AF012891
    UniProtKB/Swiss-Prot
    Q9JLS4
    Related
    ENSRNOP00000075046, ENSRNOT00000079368
    Conserved Domains (2) summary
    cl02447
    Location:20146
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
    cl02512
    Location:188296
    NTR_like; NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

    Range
    47383983..47394065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000085.1 Alternate Rn_Celera

    Range
    51198532..51208589
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)