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CCND3 cyclin D3 [ Homo sapiens (human) ]

Gene ID: 896, updated on 18-Oct-2014
Official Symbol
CCND3provided by HGNC
Official Full Name
cyclin D3provided by HGNC
Primary source
HGNC:HGNC:1585
Locus tag
RP5-973N23.3
See related
Ensembl:ENSG00000112576; HPRD:00452; MIM:123834; Vega:OTTHUMG00000014690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
See CCND3 in Epigenomics, MapViewer
Location:
6p21
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 6 NC_000006.12 (41934933..42048894, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (41902671..42016610, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 20 Neighboring gene bystin-like Neighboring gene TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa Neighboring gene chromosome 6 open reading frame 132

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
NHGRI GWA Catalog
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.
NHGRI GWA Catalog
Genome-wide association study of hematological and biochemical traits in a Japanese population.
NHGRI GWA Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
NHGRI GWA Catalog
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.
NHGRI GWA Catalog
Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
NHGRI GWA Catalog
Seventy-five genetic loci influencing the human red blood cell.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed

Go to the HIV-1, Human Interaction Database

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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cyclin-dependent protein kinase holoenzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
G1/S-specific cyclin-D3
Names
G1/S-specific cyclin-D3
D3-type cyclin
G1/S-specific cyclin D3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136017.3NP_001129489.1  G1/S-specific cyclin-D3 isoform 1

    See proteins identical to NP_001129489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence, and represents use of an alternate promoter, compared to variant 2. The resulting isoform (1) is shorter at the N-terminus compared to isoform 2.
    Source sequence(s)
    AK057206, AL160163, BC011616, DA999482, DB001987
    Consensus CDS
    CCDS47426.1
    UniProtKB/Swiss-Prot
    P30281
    Related
    ENSP00000362079, OTTHUMP00000223408, ENST00000372988, OTTHUMT00000372249
    Conserved Domains (2) summary
    cd00043
    Location:164
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam02984
    Location:74180
    Cyclin_C; Cyclin, C-terminal domain
  2. NM_001136125.2NP_001129597.1  G1/S-specific cyclin-D3 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 2.
    Source sequence(s)
    AK057206, AL160163, BC011616, DC360231, M92287
    Consensus CDS
    CCDS47425.1
    UniProtKB/Swiss-Prot
    P30281
    Related
    ENSP00000397545, OTTHUMP00000223406, ENST00000414200, OTTHUMT00000372246
    Conserved Domains (2) summary
    pfam02984
    Location:83189
    Cyclin_C; Cyclin, C-terminal domain
    cl00050
    Location:2666
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
  3. NM_001136126.2NP_001129598.1  G1/S-specific cyclin-D3 isoform 4

    See proteins identical to NP_001129598.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (4) is shorter at the N-terminus compared to isoform 2. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AK057206, AL160163, BC011616, DA069566, DA999482, DB001987
    Consensus CDS
    CCDS47427.1
    UniProtKB/Swiss-Prot
    P30281
    Related
    ENSP00000401595, OTTHUMP00000223409, ENST00000415497, OTTHUMT00000372250
    Conserved Domains (1) summary
    pfam02984
    Location:165
    Cyclin_C; Cyclin, C-terminal domain
  4. NM_001287427.1NP_001274356.1  G1/S-specific cyclin-D3 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the 5' coding region and uses a downstream start codon compared to variant 2. It encodes isoform 5 which has a shorter N-terminus compared to isoform 2.
    Source sequence(s)
    AK055519, AL160163, BC011616, BE247367, BG996045, DA411470, M92287
    Consensus CDS
    CCDS75452.1
    UniProtKB/TrEMBL
    B3KP19
    UniProtKB/Swiss-Prot
    P30281
    UniProtKB/TrEMBL
    Q5T8J1
    Related
    ENSP00000362078, OTTHUMP00000016391, ENST00000372987, OTTHUMT00000040541
    Conserved Domains (2) summary
    cd00043
    Location:1595
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam02984
    Location:105211
    Cyclin_C; Cyclin, C-terminal domain
  5. NM_001287434.1NP_001274363.1  G1/S-specific cyclin-D3 isoform 4

    See proteins identical to NP_001274363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, and represents use of an alternate promoter, compared to variant 2. The resulting isoform (4) is shorter at the N-terminus compared to isoform 2. Variants 4 and 5 encode the same protein.
    Source sequence(s)
    AL513008, BX117734, CA424172, DA999482, DB104254, DB110132, DB544217, DC405843, DR761231
    Consensus CDS
    CCDS47427.1
    UniProtKB/Swiss-Prot
    P30281
    Related
    ENSP00000484424, ENST00000616010
    Conserved Domains (1) summary
    pfam02984
    Location:165
    Cyclin_C; Cyclin, C-terminal domain
  6. NM_001760.4NP_001751.1  G1/S-specific cyclin-D3 isoform 2

    See proteins identical to NP_001751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the largest isoform (2).
    Source sequence(s)
    AK057206, AL160163, BC011616, M92287
    Consensus CDS
    CCDS4863.1
    UniProtKB/Swiss-Prot
    P30281
    Related
    ENSP00000362082, OTTHUMP00000016390, ENST00000372991, OTTHUMT00000040540
    Conserved Domains (2) summary
    cd00043
    Location:56145
    CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
    pfam02984
    Location:155261
    Cyclin_C; Cyclin, C-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000006.12 

    Range
    41934933..42048894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000138.1 

    Range
    41621515..41734588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 

    Range
    41905431..42019165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)