BTRC beta-transducin repeat containing E3 ubiquitin protein ligase [ Homo sapiens ]

Gene ID: 8945, updated on 20-May-2012

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Summary

Official Symbol: BTRCprovided by HGNC
Official Full Name: beta-transducin repeat containing E3 ubiquitin protein ligaseprovided by HGNC
Primary source: HGNC:1144
Locus tag: RP11-529I10.2
See related: Ensembl:ENSG00000166167; HPRD:04596; MIM:603482; Vega:OTTHUMG00000018932
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP; MGC4643
Summary: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

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Genomic context

Location :: 10q24.32

Sequence :: Chromosome: 10; NC_000010.10 (103113825..103317070)

See BTRC in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

IL-10R1 is a novel substrate of betaTrCP-containing ubiquitin E3 ligase, a novel negative regulatory mechanism that may potentially affect IL-10 function
Title: Regulation of interleukin-10 receptor ubiquitination and stability by beta-TrCP-containing ubiquitin E3 ligase.
Data indicate that knockdown of beta-TrCP1 and beta-TrCP2 markedly reduced IL-17-induced, phosphorylation-dependent ubiquitination and degradation of Act1.
Title: Persistent stimulation with interleukin-17 desensitizes cells through SCFβ-TrCP-mediated degradation of Act1.
mTOR generates an auto-amplification loop by triggering the betaTrCP- and CK1alpha-dependent degradation of DEPTOR
Title: mTOR generates an auto-amplification loop by triggering the βTrCP- and CK1α-dependent degradation of DEPTOR.
Endogenous DEPTOR levels are negatively regulated by betaTrCP.
Title: DEPTOR, an mTOR inhibitor, is a physiological substrate of SCF(βTrCP) E3 ubiquitin ligase and regulates survival and autophagy.
mTOR drives its own activation via SCF(betaTrCP)-dependent degradation of the mTOR inhibitor DEP
Title: mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.
mediates stress-activated MAPK-induced Cdc25B degradation
Title: SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.
F box protein betaTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
Title: βTrCP regulates BMI1 protein turnover via ubiquitination and degradation.
the cellular localization of beta-TrCP1 is altered in glioblastoma, resulting in dysregulation of PHLPP1 and other substrates such as beta-catenin.
Title: Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt.
beta-TrCP is not strictly required for Vpu's ability to counteract the CD317-imposed virion release block and support the relevance of cell surface down-modulation of the restriction factor as a central mechanism of Vpu antagonism.
Title: β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.
the substrate binding domain of beta TrCP is the dominant localisation determinant
Title: Specificity, location and function of βTrCP isoforms and their splice variants.

Submit: New GeneRIF Correction See all (72)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Vpu	vpu	Binding of HIV-1 Vpu to beta-TrCP requires two phosphoserine residues on Vpu (amino acids 52 and 56) and results in recruitment of beta-TrCP to cellular membranes	PubMed
	vpu	Through binding to beta-TrCP, HIV-1 Vpu targets CD4 for degradation in the endoplasmic reticulum and also inhibits IkappaB-alpha degradation as well as NF-kappaB activation	PubMed
	vpu	HIV-1 Vpu is a strong competitive inhibitor of beta-TrCP and impairs the degradation of SCF-beta-TrCP substrates such as IKBalpha, ATF4 and beta-catenin	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
AAF04464.1	NP_008861.2	SKP1	BIND	PubMed	Skp1 interacts with Fbw1a.
NC_000010.8	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with BTRC promoter.
NP_003930.1	NP_065390.1	NFKBIA	BIND	PubMed	h-beta-TrCP interacts with and promotes ubiquitination of phosphorylated I-kappa-B-alpha. This interaction was modeled on a demonstrated interaction between human beta-TrCP (h-beta-TrCP) and I-kappa-B-alpha from an unspecified species.
Q9Y297	O15169	AXIN1	HPRD	PubMed
Q9Y297	Q9Y297	BTRC	HPRD	PubMed
Q9Y297	P30304	CDC25A	HPRD	PubMed
Q9Y297	P49427	CDC34	HPRD	PubMed
Q9Y297	P35222	CTNNB1	HPRD	PubMed
Q9Y297	Q13616	CUL1	HPRD	PubMed
Q9Y297	Q15398	DLGAP5	HPRD	PubMed
Q9Y297	Q9UKB1	FBXW11	HPRD	PubMed
Q9Y297	Q00839	HNRNPU	HPRD	PubMed
Q9Y297	P14923	JUP	HPRD	PubMed
Q9Y297	P19838	NFKB1	HPRD	PubMed
Q9Y297	Q00653	NFKB2	HPRD	PubMed
Q9Y297	P25963	NFKBIA	HPRD	PubMed
Q9Y297	Q15653	NFKBIB	HPRD	PubMed
Q9Y297	Q04206	RELA	HPRD	PubMed
Q9Y297	P63208	SKP1	HPRD	PubMed
Q9Y297	P84022	SMAD3	HPRD	PubMed
Q9Y297	Q13485	SMAD4	HPRD	PubMed
Q9Y297	Q9UMX1	SUFU	HPRD	PubMed
Q9Y297	Q9C026	TRIM9	HPRD	PubMed
Q9Y297	O95858	TSPAN15	HPRD	PubMed
Q9Y297	P62837	UBE2D2	HPRD	PubMed
Q9Y297	Q712K3	UBE2R2	HPRD	PubMed
Q9Y297	Q9UHD9	UBQLN2	HPRD	PubMed
Q9Y297	P30291	WEE1	HPRD	PubMed
BioGRID:114457	BioGRID:106821	APC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114457	BioGRID:106958	ATF4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114457	BioGRID:113909	AXIN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:107116	BMI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:122954	BORA	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:107149	BST2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:107286	CASP3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:107358	CD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:107428	CDC25A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:107429	CDC25B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114457	BioGRID:107432	CDC34	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114457	BioGRID:116056	CLPX	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:122015	CLSPN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:107603	CLU	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:119324	COPS4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:107843	CSNK2B	BioGRID	PubMed	Affinity Capture-Western
	NP_001895.1	CTNNB1	BIND	PubMed	BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin).
BioGRID:114457	BioGRID:107880	CTNNB1	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide; Reconstituted Complex; Two-hybrid
BioGRID:114457	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114457	BioGRID:107995	DBN1	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:122304	DEPTOR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114457	BioGRID:108083	DLG1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:108347	EP300	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:108371	EPOR	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:126556	FAM123B	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:117655	FBXO5	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:116887	FBXW11	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114457	BioGRID:117645	FBXW8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:108955	GH1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:108957	GHR	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:108999	GLI3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:125399	GPRASP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:109187	GSK3B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:117045	HEY2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:118815	HIPK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:109343	HIVEP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:109344	HIVEP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:109433	HNRNPU	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:109501	HRAS	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:109676	IFNAR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:109727	IGHM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:109767	IKBKB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:114089	IKBKG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:109931	JUP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:109992	KDR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:115156	KEAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:116955	KIAA0947	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:130796	KRT79	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:107819	MAPK14	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:110694	MYC	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114457	BioGRID:110815	NEDD8	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:110857	NFKB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:110858	NFKB2	BioGRID	PubMed	Affinity Capture-Western; Protein-peptide
BioGRID:114457	BioGRID:110859	NFKBIA	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Protein-peptide; Reconstituted Complex; Two-hybrid
BioGRID:114457	BioGRID:110860	NFKBIB	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:110954	NRD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:115950	NUDC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:114049	OGT	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:111133	PCDH8	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:118098	PDCD4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:111210	PER1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:116843	PHLPP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:111553	PRKACA	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:111683	PSMD4	BioGRID	PubMed	Biochemical Activity
BioGRID:114457	BioGRID:114663	PTTG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:111856	RASA1	BioGRID	PubMed	Phenotypic Suppression
BioGRID:114457	BioGRID:116356	RASSF1	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:111902	RELA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:112224	SERPINB4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:112391	SKP1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid
BioGRID:114457	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:110264	SMAD4	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114457	BioGRID:112499	SNAI1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:112509	SNRNP70	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:112550	SP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:117312	SUN2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:118878	TBK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:112979	TNF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114457	BioGRID:114181	TP63	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114457	BioGRID:125280	TRIM9	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:116055	TUBGCP2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:115695	TUBGCP3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:113165	UBA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114457	BioGRID:113169	UBE2D1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:113170	UBE2D2	BioGRID	PubMed	Biochemical Activity
BioGRID:114457	BioGRID:113171	UBE2D3	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:120266	UBE2R2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:31215	UBI4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:120360	USP47	BioGRID	PubMed	Affinity Capture-MS
	NP_003381.1	WEE1	BIND	PubMed	Wee1A interacts with an unspecified isoform of beta-TrCP1.
BioGRID:114457	BioGRID:113303	WEE1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114457	BioGRID:115684	YAP1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114457	BioGRID:123141	ZC3H12A	BioGRID	PubMed	Two-hybrid
BioGRID:114457	BioGRID:592515	cdc25a	BioGRID	PubMed	Reconstituted Complex
BioGRID:114457	BioGRID:1205543	vpu	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
beta-catenin binding	IEA Inferred from Electronic Annotation more info
ligase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein dimerization activity	IEA Inferred from Electronic Annotation more info
protein phosphorylated amino acid binding	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
ubiquitin-protein ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IEA Inferred from Electronic Annotation more info
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process	TAS Traceable Author Statement more info
branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
interspecies interaction between organisms	IEA Inferred from Electronic Annotation more info
mammary gland epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	TAS Traceable Author Statement more info
negative regulation of sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
negative regulation of smoothened signaling pathway	TAS Traceable Author Statement more info	PubMed
negative regulation of transcription, DNA-dependent	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info
positive regulation of proteolysis	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS Traceable Author Statement more info
protein catabolic process	IEA Inferred from Electronic Annotation more info
protein dephosphorylation	IEA Inferred from Electronic Annotation more info
protein destabilization	IMP Inferred from Mutant Phenotype more info	PubMed
protein polyubiquitination	IEA Inferred from Electronic Annotation more info
protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
regulation of I-kappaB kinase/NF-kappaB cascade	IEA Inferred from Electronic Annotation more info
regulation of cell cycle	IEA Inferred from Electronic Annotation more info
regulation of proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle	TAS Traceable Author Statement more info
signal transduction	TAS Traceable Author Statement more info	PubMed
ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
viral reproduction	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
cytosol	TAS Traceable Author Statement more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: F-box/WD repeat-containing protein 1A

Names: F-box/WD repeat-containing protein 1A; beta-TrCP1; E3RSIkappaB; F-box and WD-repeat protein 1B; pIkappaBalpha-E3 receptor subunit; F-box and WD repeats protein beta-TrCP

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009234.1 RefSeqGene

Range

4966..208254

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256856.1 → NP_001243785.1 F-box/WD repeat-containing protein 1A isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AK313417, BC006204, BM680713, CR749295, DA218668

UniProtKB/TrEMBL

B2R8L3

UniProtKB/TrEMBL

B7Z3H4

UniProtKB/TrEMBL

Q68DS0

Conserved Domains (3) summary

cd00200
Location:277 – 555
Blast Score: 579

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl13550
Location:112 – 151
Blast Score: 233

Beta-TrCP_D; D domain of beta-TrCP

cl02535
Location:155 – 202
Blast Score: 130

F-box; F-box domain
NM_003939.4 → NP_003930.1 F-box/WD repeat-containing protein 1A isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AF129530, AK313417, BC006204, BM680713, CR749295, DA218668

Consensus CDS

CCDS7511.1

UniProtKB/TrEMBL

B2R8L3

UniProtKB/TrEMBL

Q68DS0

UniProtKB/Swiss-Prot

Q9Y297

Related

ENSP00000385339, OTTHUMP00000020315, ENST00000408038, OTTHUMT00000049937

Conserved Domains (3) summary

cd00200
Location:267 – 545
Blast Score: 585

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl13550
Location:102 – 141
Blast Score: 232

Beta-TrCP_D; D domain of beta-TrCP

cl02535
Location:145 – 192
Blast Score: 131

F-box; F-box domain
NM_033637.3 → NP_378663.1 F-box/WD repeat-containing protein 1A isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK313417, BC006204, BC027994, BM680713, CR749295, DA218668

Consensus CDS

CCDS7512.1

UniProtKB/TrEMBL

B2R8L3

UniProtKB/TrEMBL

Q5W141

UniProtKB/TrEMBL

Q68DS0

UniProtKB/Swiss-Prot

Q9Y297

Related

ENSP00000359206, OTTHUMP00000020314, ENST00000370187, OTTHUMT00000049936

Conserved Domains (3) summary

cd00200
Location:303 – 581
Blast Score: 585

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cl13550
Location:138 – 177
Blast Score: 234

Beta-TrCP_D; D domain of beta-TrCP

cl02535
Location:181 – 228
Blast Score: 130

F-box; F-box domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

103113825..103317070

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

96743735..96947667

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL133387.8	CAH70019.1
		CAH70020.1
genomic	AL445463.8	CAI12962.1
		CAI12963.1
		CAI12964.1
genomic	AL627424.8	CAI41042.1
		CAI41043.1
genomic	AL833133.1	None
genomic	CH471066.2	EAW49770.1
		EAW49771.1
		EAW49772.1
		EAW49773.1
		EAW49774.1
mRNA	AA824369.1	None
mRNA	AF101784.1	AAD08702.1
mRNA	AF129530.1	AAF04464.1
mRNA	AK295870.1	BAH12210.1
mRNA	AK313353.1	BAG36155.1
mRNA	AK313417.1	BAG36210.1
mRNA	AK314880.1	BAG37395.1
mRNA	AL707686.1	None
mRNA	AY207475.1	AAO59171.1
mRNA	AY207476.1	AAO59172.1
mRNA	BC006204.2	None
mRNA	BC027994.1	AAH27994.1
mRNA	BC063673.1	None
mRNA	BM680713.1	None
mRNA	BQ188694.1	None
mRNA	BX389753.2	None
mRNA	CR749295.1	CAH18150.1
mRNA	DA218668.1	None
mRNA	GU727631.1	ADU87633.1
mRNA	Y14153.1	CAA74572.1
other-genetic	JF432214.1	ADZ15431.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q5T1W7	GenPept	UniProtKB/TrEMBL:Q5T1W7
Q5W141	GenPept	UniProtKB/TrEMBL:Q5W141
Q68DS0	GenPept	UniProtKB/TrEMBL:Q68DS0
Q86WI4	GenPept	UniProtKB/TrEMBL:Q86WI4
Q86WI5	GenPept	UniProtKB/TrEMBL:Q86WI5
Q9Y297.1	GenPept	UniProtKB/Swiss-Prot:Q9Y297