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KYNU kynureninase [ Homo sapiens (human) ]

Gene ID: 8942, updated on 27-Jun-2015
Official Symbol
KYNUprovided by HGNC
Official Full Name
kynureninaseprovided by HGNC
Primary source
HGNC:HGNC:6469
See related
Ensembl:ENSG00000115919; HPRD:08940; MIM:605197; Vega:OTTHUMG00000131829
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KYNUU
Summary
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Orthologs
See KYNU in Epigenomics, MapViewer
Location:
2q22.2
Exon count:
23
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (142748928..143042316)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (143506497..143799885)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373651 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1 pseudogene Neighboring gene RNA polymerase I-specific transcription initiation factor RRN3-like Neighboring gene uncharacterized LOC105373652 Neighboring gene sideroflexin 4 pseudogene Neighboring gene stress-induced phosphoprotein 1 pseudogene 1 Neighboring gene Rho GTPase activating protein 15 Neighboring gene MT-ND5 pseudogene 24 Neighboring gene MT-ND4 pseudogene 22

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Hydroxykynureninuria
MedGen: C0268474 OMIM: 236800 GeneReviews: Not available
not available

NHGRI GWAS Catalog

Description
Genome-wide association study of selenium concentrations.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of kynureninase (KYNU) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
  • Protein export, organism-specific biosystem (from KEGG)
    Protein export, organism-specific biosystemThe protein export is the active transport of proteins from the cytoplasm to the exterior of the cell, or to the periplasmic compartment in Gram-negative bacteria. The sec dependent pathway is the ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kynureninase activity IDA
Inferred from Direct Assay
more info
PubMed 
kynureninase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
kynureninase activity TAS
Traceable Author Statement
more info
 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
 
L-kynurenine catabolic process IEA
Inferred from Electronic Annotation
more info
 
anthranilate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
quinolinate biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
response to interferon-gamma IDA
Inferred from Direct Assay
more info
PubMed 
response to vitamin B6 IMP
Inferred from Mutant Phenotype
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
tryptophan catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
tryptophan catabolic process TAS
Traceable Author Statement
more info
 
tryptophan catabolic process to acetyl-CoA IEA
Inferred from Electronic Annotation
more info
 
tryptophan catabolic process to kynurenine IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
kynureninase
Names
kynureninase
KYNU
L-kynurenine hydrolase
NP_001028170.1
NP_001186170.1
NP_003928.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023254.1 RefSeqGene

    Range
    5001..169691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001032998.1NP_001028170.1  kynureninase isoform b

    See identical proteins and their annotated locations for NP_001028170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, 3' UTR and coding region compared to variant 3. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AL548658, BC000879
    Consensus CDS
    CCDS33299.1
    UniProtKB/Swiss-Prot
    Q16719
    Conserved Domains (1) summary
    cl18945
    Location:24306
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. NM_001199241.1NP_001186170.1  kynureninase isoform a

    See identical proteins and their annotated locations for NP_001186170.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents the longest transcript variant. Variants 1 and 3 encode isoform a.
    Source sequence(s)
    AC013437, AK315343, AW290980, CB151988
    Consensus CDS
    CCDS2183.1
    UniProtKB/Swiss-Prot
    Q16719
    Related
    ENSP00000386731, OTTHUMP00000204304, ENST00000409512, OTTHUMT00000332170
    Conserved Domains (2) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
    cl18945
    Location:24462
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. NM_003937.2NP_003928.1  kynureninase isoform a

    See identical proteins and their annotated locations for NP_003928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5'UTR compared to variant 3.
    Source sequence(s)
    AL548658, AW296221, U57721
    Consensus CDS
    CCDS2183.1
    UniProtKB/Swiss-Prot
    Q16719
    Conserved Domains (2) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
    cl18945
    Location:24462
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    142748928..143042316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512101.1XP_011510403.1  

    See identical proteins and their annotated locations for XP_011510403.1

    Conserved Domains (2) summary
    TIGR01814
    Location:30459
    kynureninase; kynureninase
    cl18945
    Location:24462
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  2. XM_011512102.1XP_011510404.1  

    See identical proteins and their annotated locations for XP_011510404.1

    Conserved Domains (1) summary
    cl18945
    Location:1329
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  3. XM_011512104.1XP_011510406.1  

    See identical proteins and their annotated locations for XP_011510406.1

    Conserved Domains (1) summary
    cl18945
    Location:1329
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  4. XM_011512103.1XP_011510405.1  

    See identical proteins and their annotated locations for XP_011510405.1

    Conserved Domains (1) summary
    cl18945
    Location:1329
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
  5. XM_011512105.1XP_011510407.1  

    See identical proteins and their annotated locations for XP_011510407.1

    Conserved Domains (1) summary
    cl18945
    Location:1329
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RNA

  1. XR_923058.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    143640202..143804900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)