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    CCNC cyclin C [ Homo sapiens ]

    Gene ID: 892, updated on 11-May-2012
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    Summary

    Official Symbol
    CCNCprovided by HGNC
    Official Full Name
    cyclin Cprovided by HGNC
    Primary source
    HGNC:1581
    Locus tag
    RP1-199J3.1
    See related
    Ensembl:ENSG00000112237; HPRD:00456; MIM:123838; Vega:OTTHUMG00000015268
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CycC
    Summary
    The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6q21
    Sequence :
    Chromosome: 6; NC_000006.11 (99990263..100016690, complement)
    See CCNC in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 45 Neighboring gene uncharacterized LOC100130890 Neighboring gene ribosomal protein S3 pseudogene 5 Neighboring gene PR domain containing 13

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Streamlined analysis schema for high-throughput identification of endogenous protein complexes. Malovannaya A, et al. Proc Natl Acad Sci U S A, 2010 Feb 9. PMID 20133760.
    4. Cyclin C regulates human hematopoietic stem/progenitor cell quiescence. Miyata Y, et al. Stem Cells, 2010 Feb. PMID 19967789.
    5. Nuclear CDKs drive Smad transcriptional activation and turnover in BMP and TGF-beta pathways. Alarcón C, et al. Cell, 2009 Nov 13. PMID 19914168.

    See all (38) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Studies establish cyclin C as a critical regulator of the G(0)/G(1) transition of human HSPCs and suggest that modulating cyclin C levels may be useful for HSC expansion and more efficient engraftment.
      Title: Cyclin C regulates human hematopoietic stem/progenitor cell quiescence.
    2. Data suggests that the primary regulation of Cyclin C by all-trans RA and Forskolin mediates some of the cell cycle control actions of these compounds.
      Title: Cell cycle regulatory effects of retinoic Acid and forskolin are mediated by the cyclin C gene.
    3. A cellular pool of cyclin C combines with cdk3 to stimulate pRb phosphorylation at S807/811 during the G0/G1 transition, and this phosphorylation is required for cells to exit G0 efficiently.
      Title: Cyclin C/cdk3 promotes Rb-dependent G0 exit.
    4. Physical chromosome mapping of the deleted region of chromosome 6 suggests that CCNC is a candidate tumor suppressor gene.
      Title: Highly frequent allelic loss of chromosome 6q16-23 in osteosarcoma: involvement of cyclin C in osteosarcoma.
    5. Identification of multiple 1alpha,25(OH)2D3 response elements in the cyclin C promoter.
      Title: Regulation of the human cyclin C gene via multiple vitamin D3-responsive regions in its promoter.
    6. The present observations suggest different cellular functions of cyclin C in neurons and astrocytes in alzheimer's disease.
      Title: Cyclin C expression is involved in the pathogenesis of Alzheimer's disease.
    7. C2 isoform may play a presently unexplored and important role in mammalian testis and probably this isoform is the one that is mainly implicated in cell cycle regulation.
      Title: Two isoforms of the human cyclin C gene are expressed differentially suggesting that they may have distinct functions.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes cyclin c, during Tat-mediated transactivation of the HIV-1 LTR PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_005181.1 NP_001249.1 CDK3    BIND  PubMed Cyclin C interacts with Cdk3. 
    P24863 Q00526 CDK3    HPRD  PubMed  
    P24863 P49336 CDK8    HPRD  PubMed  
    P24863 Q96G25 MED8    HPRD  PubMed  
    BioGRID:107333 BioGRID:107458 CDK8    BioGRID  PubMed Affinity Capture-Western; Co-fractionation; Co-purification; Reconstituted Complex 
    BioGRID:107333 BioGRID:107777 CREBBP    BioGRID  PubMed Co-fractionation 
    BioGRID:107333 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107333 BioGRID:108404 ESR2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107333 BioGRID:110339 MCM2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107333 BioGRID:111465 MED1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:123974 MED10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107333 BioGRID:115293 MED12    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:120156 MED18    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:128553 MED19    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:123219 MED28    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:120734 MED29    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107333 BioGRID:116719 ZC3H13    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the CCNC gene: The CCNC gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, , A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
      Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • PPARA Activates Gene Expression, organism-specific biosystem (from REACTOME)
      PPARA Activates Gene Expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
    • Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
      Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation of White Adipocyte Differentiation, organism-specific biosystemAdipogenesis is the process of cell differentiation by which preadipocytes become adipocytes. During this process the preadipocytes cease to proliferate, begin to accumulate lipid droplets and develo...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    DNA-directed RNA polymerase II, holoenzyme IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cyclin-C
    Names
    cyclin-C
    hSRB11
    SRB11 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013399.1 → NP_001013417.1  cyclin-C isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1, that results in the use of a downstream translational start codon. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      BC056153, BM788717
      Consensus CDS
      CCDS47461.1
      UniProtKB/Swiss-Prot
      P24863
      UniProtKB/TrEMBL
      Q7Z4L3
      Related
      ENSP00000430014, OTTHUMP00000225539, ENST00000523799, OTTHUMT00000376697
      Conserved Domains (2) summary
      COG5333
      Location:2 – 158
      Blast Score: 217
      CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]
      cl00050
      Location:76 – 151
      Blast Score: 100
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    2. NM_005190.3 → NP_005181.2  cyclin-C isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      BC041123, BC056153, BM788717
      Consensus CDS
      CCDS34502.1
      UniProtKB/Swiss-Prot
      P24863
      UniProtKB/TrEMBL
      Q7Z4L3
      Related
      ENSP00000428982, OTTHUMP00000016897, ENST00000520429, OTTHUMT00000041613
      Conserved Domains (2) summary
      cd00043
      Location:48 – 99
      Blast Score: 113
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
      cl00050
      Location:161 – 236
      Blast Score: 100
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      99990263..100016690, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      97430596..97457015, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL137784.14 CAC14563.1
      CAI19762.1
    genomic CH471051.2 EAW48465.1
      EAW48466.1
      EAW48467.1
      EAW48468.1
    genomic U40739.1 AAC50825.1
    mRNA AB125137.1 BAD00144.1
    mRNA AK130983.1 None
    mRNA AK222768.1 None
    mRNA AK223247.1 None
    mRNA AK291914.1 BAF84603.1
    mRNA AK298558.1 BAG60753.1
    mRNA BC010135.2 AAH10135.1
    mRNA BC026272.1 AAH26272.1
    mRNA BC030159.2 None
    mRNA BC041123.1 AAH41123.1
    mRNA BC050726.2 None
    mRNA BC056153.1 AAH56153.1
    mRNA BM788717.1 None
    mRNA M74091.1 None
    other-genetic HQ448076.1 ADQ32557.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24863.2 GenPept UniProtKB/Swiss-Prot:P24863
    Q7Z4L3 GenPept UniProtKB/TrEMBL:Q7Z4L3
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
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