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HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 8916, updated on 27-Sep-2014
Official Symbol
HERC3provided by HGNC
Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:4876
See related
Ensembl:ENSG00000138641; HPRD:16093; MIM:605200; Vega:OTTHUMG00000150436
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
See HERC3 in Epigenomics, MapViewer
Location:
4q21
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 4 NC_000004.12 (88592423..88708542)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (89513574..89629693)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929134 Neighboring gene CD53 molecule pseudogene Neighboring gene RNA, U6 small nuclear 33, pseudogene Neighboring gene FAM13A antisense RNA 1 Neighboring gene nucleosome assembly protein 1-like 5 Neighboring gene uncharacterized LOC102723488 Neighboring gene family with sequence similarity 13, member A

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasmic membrane-bounded vesicle IEA
Inferred from Electronic Annotation
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
probable E3 ubiquitin-protein ligase HERC3
Names
probable E3 ubiquitin-protein ligase HERC3
hect domain and RLD 3
HECT domain and RCC1-like domain-containing protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271602.1NP_001258531.1  probable E3 ubiquitin-protein ligase HERC3 isoform 2

    See proteins identical to NP_001258531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and portion of the 5' coding region. These differences cause translation initiation at a downstream AUG and result in an isoform (2) which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK296379, BE044630, BQ925135, D25215, DA333248
    UniProtKB/TrEMBL
    B4DK41
    UniProtKB/Swiss-Prot
    Q15034
    Conserved Domains (5) summary
    smart00119
    Location:608929
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    COG5184
    Location:134383
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]
    cd00078
    Location:584930
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:90139
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:2150
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. NM_014606.2NP_055421.1  probable E3 ubiquitin-protein ligase HERC3 isoform 1

    See proteins identical to NP_055421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK289990, BE044624, D25215, DA333248
    Consensus CDS
    CCDS34028.1
    UniProtKB/Swiss-Prot
    Q15034
    Related
    ENSP00000385684, OTTHUMP00000197355, ENST00000402738, OTTHUMT00000318081
    Conserved Domains (4) summary
    smart00119
    Location:7261047
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000004.12 

    Range
    88592423..88708542
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263330.1XP_005263387.1  

    Conserved Domains (4) summary
    smart00119
    Location:676990
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:676991
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  2. XM_005263329.1XP_005263386.1  

    See proteins identical to XP_005263386.1

    Conserved Domains (4) summary
    smart00119
    Location:7181039
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:6941040
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  3. XM_006714405.1XP_006714468.1  

    Conserved Domains (4) summary
    smart00119
    Location:672993
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:648994
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:155203
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  4. XM_005263331.1XP_005263388.1  

    Conserved Domains (3) summary
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    cl00077
    Location:702887
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  5. XM_005263332.2XP_005263389.1  

    Conserved Domains (3) summary
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
    cl00077
    Location:702886
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
  6. XM_005263327.1XP_005263384.1  

    See proteins identical to XP_005263384.1

    UniProtKB/Swiss-Prot
    Q15034
    Conserved Domains (4) summary
    smart00119
    Location:7261047
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat
  7. XM_005263328.1XP_005263385.1  

    See proteins identical to XP_005263385.1

    UniProtKB/Swiss-Prot
    Q15034
    Conserved Domains (4) summary
    smart00119
    Location:7261047
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:7021048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam00415
    Location:208257
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    pfam13540
    Location:3665
    RCC1_2; Regulator of chromosome condensation (RCC1) repeat

Alternate HuRef

Genomic

  1. AC_000136.1 

    Range
    85265488..85382068
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 

    Range
    89490048..89606164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)