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    HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 [ Homo sapiens ]

    Gene ID: 8916, updated on 11-May-2012
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    Summary

    Official Symbol
    HERC3provided by HGNC
    Official Full Name
    HECT and RLD domain containing E3 ubiquitin protein ligase 3provided by HGNC
    Primary source
    HGNC:4876
    See related
    Ensembl:ENSG00000138641; HPRD:16093; MIM:605200; Vega:OTTHUMG00000150436
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0032
    Summary
    HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    4q21
    Sequence :
    Chromosome: 4; NC_000004.11 (89513647..89629686)
    See HERC3 in Epigenomics, MapViewer

    Chromosome 4 - NC_000004.11Genomic Context describing neighboring genes Neighboring gene CD53 molecule pseudogene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class Y Neighboring gene FAM13A antisense RNA 1 (non-protein coding) Neighboring gene nucleosome assembly protein 1-like 5 Neighboring gene family with sequence similarity 13, member A Neighboring gene uncharacterized LOC731282

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability. Yoo NJ, et al. Pathology, 2011 Dec. PMID 22124266.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    4. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    5. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. we found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
      Title: Frameshift mutations of ubiquitination-related genes HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B in gastric and colorectal carcinomas with microsatellite instability.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15034 P62987 UBA52    HPRD  PubMed  
    BioGRID:114430 BioGRID:120340 HERC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114430 BioGRID:110895 NME2    BioGRID  PubMed Two-hybrid 
    BioGRID:114430 BioGRID:112938 TK1    BioGRID  PubMed Two-hybrid 
    BioGRID:114430 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:114430 BioGRID:119007 UBQLN1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114430 BioGRID:119006 UBQLN2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    protein modification process IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasmic membrane-bounded vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    probable E3 ubiquitin-protein ligase HERC3
    Names
    probable E3 ubiquitin-protein ligase HERC3
    hect domain and RLD 3
    HECT domain and RCC1-like domain-containing protein 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_014606.1 → NP_055421.1  probable E3 ubiquitin-protein ligase HERC3

      Status: PROVISIONAL

      Source sequence(s)
      D25215
      Consensus CDS
      CCDS34028.1
      UniProtKB/Swiss-Prot
      Q15034
      Related
      ENSP00000385684, OTTHUMP00000197355, ENST00000402738, OTTHUMT00000318081
      Conserved Domains (4) summary
      cd00078
      Location:702 – 1048
      Blast Score: 927
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      smart00119
      Location:726 – 1047
      Blast Score: 920
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      pfam00415
      Location:208 – 257
      Blast Score: 169
      RCC1; Regulator of chromosome condensation (RCC1) repeat
      pfam13540
      Location:36 – 65
      Blast Score: 123
      RCC1_2; Regulator of chromosome condensation (RCC1) repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000004.11 Reference GRCh37.p5 Primary Assembly

      Range
      89513647..89629686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000136.1 Alternate HuRef

      Range
      85265561..85382061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC098582.2 AAY41038.1
    genomic AC108065.3 None
    genomic CH471057.1 EAX06024.1
    mRNA AK289990.1 BAF82679.1
    mRNA AK296379.1 BAG59053.1
    mRNA AK296397.1 BAG59064.1
    mRNA BC038960.1 AAH38960.1
    mRNA D25215.1 BAA04945.2
    other-genetic BC166672.1 AAI66672.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15034.1 GenPept UniProtKB/Swiss-Prot:Q15034
    Q4W5H5 GenPept UniProtKB/TrEMBL:Q4W5H5
    Q8IXX3 GenPept UniProtKB/TrEMBL:Q8IXX3
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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