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TIMELESS timeless circadian clock [ Homo sapiens (human) ]

Gene ID: 8914, updated on 7-Aug-2014
Official Symbol
TIMELESSprovided by HGNC
Official Full Name
timeless circadian clockprovided by HGNC
Primary source
HGNC:11813
See related
Ensembl:ENSG00000111602; HPRD:04864; MIM:603887; Vega:OTTHUMG00000170600
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIM; TIM1; hTIM
Summary
The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]
See TIMELESS in Epigenomics, MapViewer
Location:
12q13.3
Exon count:
29
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (56416373..56449416, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56810157..56843200, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene apolipoprotein F pseudogene Neighboring gene TBCC domain containing 1 pseudogene Neighboring gene major intrinsic protein of lens fiber Neighboring gene SPRY domain containing 4 Neighboring gene glutaminase 2 (liver, mitochondrial)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12640, FLJ20714

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
branching morphogenesis of an epithelial tube IEA
Inferred from Electronic Annotation
more info
 
cell cycle phase transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
detection of abiotic stimulus TAS
Traceable Author Statement
more info
PubMed 
embryo development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
morphogenesis of an epithelium ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 
response to abiotic stimulus TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IC
Inferred by Curator
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
protein timeless homolog
Names
protein timeless homolog
Tof1 homolog
timeless homolog
timeless circadian clock 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003920.3NP_003911.2  protein timeless homolog

    See proteins identical to NP_003911.2

    Status: REVIEWED

    Source sequence(s)
    AF098162, AK000721, BC031514, BE503292, BP363571
    Consensus CDS
    CCDS8918.1
    UniProtKB/Swiss-Prot
    Q9UNS1
    Related
    ENSP00000450607, OTTHUMP00000244115, ENST00000553532, OTTHUMT00000409771
    Conserved Domains (2) summary
    pfam04821
    Location:21285
    Blast Score: 944
    TIMELESS; Timeless protein
    pfam05029
    Location:7281200
    Blast Score: 1410
    TIMELESS_C; Timeless protein C terminal region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    56416373..56449416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    53849203..53882241
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    56777536..56810809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)