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CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit [ Homo sapiens (human) ]

Gene ID: 8913, updated on 12-Apr-2014
Official Symbol
CACNA1Gprovided by HGNC
Official Full Name
calcium channel, voltage-dependent, T type, alpha 1G subunitprovided by HGNC
Primary source
HGNC:1394
See related
Ensembl:ENSG00000006283; HPRD:04961; MIM:604065; Vega:OTTHUMG00000162180
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NBR13; Cav3.1; Ca(V)T.1
Summary
Voltage-sensitive calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death. This gene encodes a T-type, low-voltage activated calcium channel. The T-type channels generate currents that are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing. Many alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Sep 2011]
Location :
17q22
Sequence :
Chromosome: 17; NC_000017.11 (50561068..50629625)
See CACNA1G in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene epsin 3 Neighboring gene CACNA1G antisense RNA 1 Neighboring gene spermatogenesis associated 20 Neighboring gene uncharacterized LOC101927253 Neighboring gene ATP-binding cassette, sub-family C (CFTR/MRP), member 3 Neighboring gene ankyrin repeat domain 40

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
NHGRI GWA Catalog
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Circadian entrainment, organism-specific biosystem (from KEGG)
    Circadian entrainment, organism-specific biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Circadian entrainment, conserved biosystem (from KEGG)
    Circadian entrainment, conserved biosystemCircadian entrainment is a fundamental property by which the period of the internal biological clock is entrained by recurring exogenous signals, such that the organism's endocrine and behavioral rhy...
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • NCAM signaling for neurite out-growth, organism-specific biosystem (from REACTOME)
    NCAM signaling for neurite out-growth, organism-specific biosystemThe neural cell adhesion molecule, NCAM, is a member of the immunoglobulin (Ig) superfamily and is involved in a variety of cellular processes of importance for the formation and maintenance of the n...
  • NCAM1 interactions, organism-specific biosystem (from REACTOME)
    NCAM1 interactions, organism-specific biosystemThe neural cell adhesion molecule, NCAM1 is generally considered as a cell adhesion mediator, but it is also considered to be a signal transducing receptor molecule. NCAM1 is involved in multiple cis...
  • Nicotine Activity on Chromaffin Cells, organism-specific biosystem (from WikiPathways)
    Nicotine Activity on Chromaffin Cells, organism-specific biosystemNicotine is an alkaloid found in tobacco plants. It is a substance that acts as a stimulant in humans and is one of the main factors responsible for tobacco dependence. When nicotine enters the body,...
  • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription
  • Type II diabetes mellitus, organism-specific biosystem (from KEGG)
    Type II diabetes mellitus, organism-specific biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
  • Type II diabetes mellitus, conserved biosystem (from KEGG)
    Type II diabetes mellitus, conserved biosystemInsulin resistance is strongly associated with type II diabetes. "Diabetogenic" factors including FFA, TNFalpha and cellular stress induce insulin resistance through inhibition of IRS1 functions. Ser...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
low voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
 
Process Evidence Code Pubs
action potential IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
calcium ion import IDA
Inferred from Direct Assay
more info
 
regulation of atrial cardiac muscle cell membrane depolarization IEA
Inferred from Electronic Annotation
more info
 
regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IDA
Inferred from Direct Assay
more info
 
response to nickel cation IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
voltage-gated calcium channel complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
voltage-dependent T-type calcium channel subunit alpha-1G
Names
voltage-dependent T-type calcium channel subunit alpha-1G
cav3.1c
voltage-gated calcium channel subunit alpha Cav3.1
voltage-dependent calcium channel alpha 1G subunit, isoform 11

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032024.1 RefSeqGene

    Range
    5001..71407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001256324.1NP_001243253.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 16

    See proteins identical to NP_001243253.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (16) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227751, BC110995, DQ494460, R43876
    Consensus CDS
    CCDS58568.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000423155, OTTHUMP00000221594, ENST00000515411, OTTHUMT00000367938
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 464
    Ion_trans; Ion transport protein
  2. NM_001256325.1NP_001243254.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 17

    See proteins identical to NP_001243254.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) has an additional segment in the central region and lacks two consecutive exons in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (17) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494471, R43876
    Consensus CDS
    CCDS58569.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000423317, OTTHUMP00000221573, ENST00000514079, OTTHUMT00000367907
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 462
    Ion_trans; Ion transport protein
  3. NM_001256326.1NP_001243255.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 18

    See proteins identical to NP_001243255.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (18) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494479, R43876
    Consensus CDS
    CCDS58574.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000426172, OTTHUMP00000221564, ENST00000513689, OTTHUMT00000367897
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 470
    Ion_trans; Ion transport protein
  4. NM_001256327.1NP_001243256.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 19

    See proteins identical to NP_001243256.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) lacks an internal segment and two consecutive exons in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (19) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227749, BC110995, DQ494461, R43876
    Consensus CDS
    CCDS58565.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000423045, OTTHUMP00000221565, ENST00000507609, OTTHUMT00000367898
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 461
    Ion_trans; Ion transport protein
  5. NM_001256328.1NP_001243257.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 20

    See proteins identical to NP_001243257.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (20) lacks three internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227751, BC110995, DQ494457, R43876
    Consensus CDS
    CCDS58567.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000425698, OTTHUMP00000221570, ENST00000514181, OTTHUMT00000367903
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 462
    Ion_trans; Ion transport protein
  6. NM_001256329.1NP_001243258.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 21

    See proteins identical to NP_001243258.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) lacks an internal segment and two consecutive exons in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (21) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494474, R43876
    Consensus CDS
    CCDS58572.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000427238, OTTHUMP00000221513, ENST00000503485, OTTHUMT00000367766
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 467
    Ion_trans; Ion transport protein
  7. NM_001256330.1NP_001243259.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 22

    See proteins identical to NP_001243259.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (22) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494476, R43876
    Consensus CDS
    CCDS58575.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000425451, OTTHUMP00000221510, ENST00000513964, OTTHUMT00000367763
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 469
    Ion_trans; Ion transport protein
  8. NM_001256331.1NP_001243260.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 23

    See proteins identical to NP_001243260.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) lacks a segment and three exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (23) lacks three internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494473, R43876
    Consensus CDS
    CCDS58573.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000426814, OTTHUMP00000221512, ENST00000510366, OTTHUMT00000367765
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 468
    Ion_trans; Ion transport protein
  9. NM_001256332.1NP_001243261.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 24

    See proteins identical to NP_001243261.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) lacks a segment and three exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (24) lacks three internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF126965, BC110995, DQ494472, R43876
    Consensus CDS
    CCDS58576.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000422407, OTTHUMP00000221511, ENST00000514717, OTTHUMT00000367764
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 465
    Ion_trans; Ion transport protein
  10. NM_001256333.1NP_001243262.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 25

    See proteins identical to NP_001243262.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) lacks two consecutive exons and a segment in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (25) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227749, BC110995, DQ494463, R43876
    Consensus CDS
    CCDS58566.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000422268, OTTHUMP00000221592, ENST00000505165, OTTHUMT00000367936
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 458
    Ion_trans; Ion transport protein
  11. NM_001256334.1NP_001243263.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 26

    See proteins identical to NP_001243263.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (26) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494467, R43876
    Consensus CDS
    CCDS58571.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000421518, OTTHUMP00000221575, ENST00000507896, OTTHUMT00000367909
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 459
    Ion_trans; Ion transport protein
  12. NM_001256359.1NP_001243288.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 27

    See proteins identical to NP_001243288.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) lacks an internal segment and two consecutive exons in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (27) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494475, R43876
    UniProtKB/Swiss-Prot
    O43497
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 466
    Ion_trans; Ion transport protein
  13. NM_001256360.1NP_001243289.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 28

    See proteins identical to NP_001243289.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (28) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494477, R43876
    UniProtKB/Swiss-Prot
    O43497
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 468
    Ion_trans; Ion transport protein
  14. NM_001256361.1NP_001243290.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 29

    See proteins identical to NP_001243290.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (29) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494478, R43876
    UniProtKB/Swiss-Prot
    O43497
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 468
    Ion_trans; Ion transport protein
  15. NM_018896.4NP_061496.2  voltage-dependent T-type calcium channel subunit alpha-1G isoform 1

    See proteins identical to NP_061496.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC004590, AF134986, AF227750, BC110995, R43876
    Consensus CDS
    CCDS45730.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000352011, OTTHUMP00000221562, ENST00000359106, OTTHUMT00000367895
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 463
    Ion_trans; Ion transport protein
  16. NM_198376.2NP_938190.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 14

    See proteins identical to NP_938190.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (14) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF124351, AF134985, BC110995, R43876
    Consensus CDS
    CCDS45736.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000350979, OTTHUMP00000221574, ENST00000358244, OTTHUMT00000367908
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 458
    Ion_trans; Ion transport protein
  17. NM_198377.2NP_938191.2  voltage-dependent T-type calcium channel subunit alpha-1G isoform 2

    See proteins identical to NP_938191.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon but has an alternate segment in the coding region and maintains the reading frame, compared to variant 1. The resulting isoform (2) is shorter and has a distinct internal segment, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227745, BC110995, DQ494470, R43876
    Consensus CDS
    CCDS58570.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000420918, OTTHUMP00000221518, ENST00000507336, OTTHUMT00000367772
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 465
    Ion_trans; Ion transport protein
  18. NM_198378.2NP_938192.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 9

    See proteins identical to NP_938192.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (9) has a distinct and smaller segment and lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227744, BC110995, R43876
    Consensus CDS
    CCDS54143.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000426261, OTTHUMP00000221509, ENST00000512389, OTTHUMT00000367762
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 463
    Ion_trans; Ion transport protein
  19. NM_198379.2NP_938193.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 7

    See proteins identical to NP_938193.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (7) lacks two internal segments and has a distinct and smaller segment, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227746, BC110995, R43876
    Consensus CDS
    CCDS54146.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000427173, OTTHUMP00000221567, ENST00000510115, OTTHUMT00000367900
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 463
    Ion_trans; Ion transport protein
  20. NM_198380.2NP_938194.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 5

    See proteins identical to NP_938194.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (5) has a distinct and smaller segment and also lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227745, BC110995, R43876
    Consensus CDS
    CCDS54142.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000426232, OTTHUMP00000221572, ENST00000515765, OTTHUMT00000367906
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 464
    Ion_trans; Ion transport protein
  21. NM_198382.2NP_938196.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 11

    See proteins identical to NP_938196.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks three exons in the coding region, compared to variant 1. The resulting isoform (11) lacks a segment in the central region and a segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227747, BC110995, R43876
    Consensus CDS
    CCDS54144.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000353990, OTTHUMP00000221515, ENST00000360761, OTTHUMT00000367769
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 460
    Ion_trans; Ion transport protein
  22. NM_198383.2NP_938197.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 6

    See proteins identical to NP_938197.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks two in-frame exons in the coding region, compared to variant 1. The resulting isoform (6) lacks a segment in the central region and a segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227748, BC110995, R43876
    Consensus CDS
    CCDS45737.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000425522, OTTHUMP00000221591, ENST00000502264, OTTHUMT00000367935
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 461
    Ion_trans; Ion transport protein
  23. NM_198384.2NP_938198.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 8

    See proteins identical to NP_938198.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two consecutive exons in the 3' coding region but maintains the reading frame, compared to variant 1. The resulting isoform (8) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227749, BC110995, R43876
    Consensus CDS
    CCDS45732.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000426098, OTTHUMP00000221569, ENST00000515165, OTTHUMT00000367902
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 462
    Ion_trans; Ion transport protein
  24. NM_198385.2NP_938199.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 4

    See proteins identical to NP_938199.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF227750, BC110995, R43876
    Consensus CDS
    CCDS45731.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000423112, OTTHUMP00000221516, ENST00000507510, OTTHUMT00000367770
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 463
    Ion_trans; Ion transport protein
  25. NM_198386.2NP_938200.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 10

    See proteins identical to NP_938200.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three exons in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (10) lacks two internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF227751, BC110995, R43876
    Consensus CDS
    CCDS45733.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000414388, OTTHUMP00000221514, ENST00000429973, OTTHUMT00000367768
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 462
    Ion_trans; Ion transport protein
  26. NM_198387.2NP_938201.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 12

    See proteins identical to NP_938201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (12) is shorter than isoform 1.
    Source sequence(s)
    AC004590, AF126966, BC110995, R43876
    Consensus CDS
    CCDS45735.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000339302, OTTHUMP00000221560, ENST00000352832, OTTHUMT00000367893
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 462
    Ion_trans; Ion transport protein
  27. NM_198388.2NP_938202.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 13

    See proteins identical to NP_938202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (13) lacks three internal segments, compared to isoform 1.
    Source sequence(s)
    AC004590, AF126965, BC110995, R43876
    Consensus CDS
    CCDS54145.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000409759, OTTHUMP00000221568, ENST00000442258, OTTHUMT00000367901
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 461
    Ion_trans; Ion transport protein
  28. NM_198396.2NP_938406.1  voltage-dependent T-type calcium channel subunit alpha-1G isoform 3

    See proteins identical to NP_938406.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. The resulting isoform (3) lacks an internal segment and has a distinct and smaller segment, compared to isoform 1.
    Source sequence(s)
    AC004590, AF134986, AF227746, BC110995, R43876
    Consensus CDS
    CCDS45734.1
    UniProtKB/Swiss-Prot
    O43497
    Related
    ENSP00000347078, ENST00000354983
    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 464
    Ion_trans; Ion transport protein

RNA

  1. NR_046054.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30) lacks an internal segment, which results in a frameshift and early translation termination, and two consecutive exons, compared to variant 1. This variant is a nonsense-mediated mRNA decay candidate and represents a non-coding transcript.
    Source sequence(s)
    AC004590, AF227749, BC110995, DQ494462, R43876
  2. NR_046055.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (31) has multiple differences, one of which results in a frameshift and early translation termination, compared to variant 1. This variant is a nonsense-mediated mRNA decay candidate and represents a non-coding transcript.
    Source sequence(s)
    AC004590, AF227744, BC110995, DQ494466, R43876
  3. NR_046056.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32) lacks three exons and an internal segment which results in a frameshift and early translation termination, compared to variant 1. This variant is a nonsense-mediated mRNA decay candidate and represents a non-coding transcript.
    Source sequence(s)
    AC004590, AF227751, BC110995, DQ494458, R43876
  4. NR_046057.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33) lacks three exons and an internal segment which results in a frameshift and early translation termination, compared to variant 1. This variant is a nonsense-mediated mRNA decay candidate and represents a non-coding transcript.
    Source sequence(s)
    AC004590, AF227747, BC110995, DQ494452, R43876
  5. NR_046058.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (34) lacks four exons and an internal segment which results in a frameshift and early translation termination, compared to variant 1. This variant is a nonsense-mediated mRNA decay candidate and represents a non-coding transcript.
    Source sequence(s)
    AC004590, AF126965, BC110995, DQ494449, R43876

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    50561068..50629625
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722160.1XP_006722223.1  

    Conserved Domains (1) summary
    pfam00520
    Location:777963
    Blast Score: 461
    Ion_trans; Ion transport protein
  2. XM_006722161.1XP_006722224.1  

    Conserved Domains (1) summary
    pfam00520
    Location:760946
    Blast Score: 462
    Ion_trans; Ion transport protein

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    44006381..44072836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    48702306..48768826
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198397.1: Suppressed sequence

    Description
    NM_198397.1: This RefSeq was permanently suppressed because it is based on an incompletely processed and 3' partial transcript.

Supplemental Content

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