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    CCNB1 cyclin B1 [ Homo sapiens ]

    Gene ID: 891, updated on 19-May-2012
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    Summary

    Official Symbol
    CCNB1provided by HGNC
    Official Full Name
    cyclin B1provided by HGNC
    Primary source
    HGNC:1579
    See related
    Ensembl:ENSG00000134057; HPRD:00454; MIM:123836; Vega:OTTHUMG00000097817
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CCNB
    Summary
    The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    5q12
    Sequence :
    Chromosome: 5; NC_000005.9 (68462913..68474072)
    See CCNB1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 3C pseudogene Neighboring gene solute carrier family 30 (zinc transporter), member 5 Neighboring gene centromere protein H Neighboring gene mitochondrial ribosomal protein S36

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Dimova NV, et al. Nat Cell Biol, 2012 Jan 29. PMID 22286100.
    2. BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner. Lara-Gonzalez P, et al. J Cell Sci, 2011 Dec 15. PMID 22193957.
    3. The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation. von Eyss B, et al. EMBO J, 2011 Dec 13. PMID 22157815.
    4. Integrative genomic analysis identifies CCNB1 and CDC2 as candidate genes associated with meningioma recurrence. Bie L, et al. Cancer Genet, 2011 Oct. PMID 22137483.
    5. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration. Chu R, et al. Biochem Pharmacol, 2012 Jan 15. PMID 22024133.

    See all (243) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. This suggests that expression of CCNB1 might be a potent tool for predicting the clinical prognosis of meningioma patients.
      Title: Integrative genomic analysis identifies CCNB1 and CDC2 as candidate genes associated with meningioma recurrence.
    2. Data show that anaphase-promoting complex or cyclosome (APC/C)-mediated multiple monoubiquitylation targeting cyclin B1 for degradation.
      Title: APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1.
    3. Tuberin binding to cyclin B1 regulates mitotic onset.
      Title: The tumor suppressor tuberin regulates mitotic onset through the cellular localization of cyclin B1.
    4. the activating phosphorylation of cyclin B1-CDK1 was tightly coupled to its T14 phosphorylation, but not Y15 phosphorylation
      Title: Coupling of T161 and T14 phosphorylations protects cyclin B-CDK1 from premature activation.
    5. Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis via Mcl-1 phosphorylation, promoting its degradation and subsequently releasing Bak from sequestration.
      Title: Cdk1/cyclin B plays a key role in mitotic arrest-induced apoptosis by phosphorylation of Mcl-1, promoting its degradation and freeing Bak from sequestration.
    6. Data show that knocking down cdk1 or cyclin B distinctly blocked the growth activity of PC3(res).
      Title: The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line.
    7. NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
      Title: NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
    8. High cyclin B1 expression significantly correlated with the high tumor grade, but not with gender, tumor size, nodal status, local tumor recurrence or p53 expression.
      Title: Cyclin B1 expression and p53 status in squamous cell carcinomas of the head and neck.
    9. overexpression of cyclin B1 could play an important role in the evolution of classical Hodgkin lymphoma
      Title: Aberrant cytoplasmic expression of cyclin B1 protein and its correlation with EBV-LMP1, P53 and P16(INK4A) in classical Hodgkin lymphoma in China.
    10. Data indicate that isochaihulactone induces G2/M cell cycle arrest via downregulation of cyclin B1 and cdc2, and induces cellular death by upregulation of NAG-1 via JNK activation in LNCaP cells.
      Title: Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells.
    Submit: New GeneRIF Correction See all (117)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Cell-cell contact between T cells expressing HIV-1 gp120/gp41 and other T cells expressing CD4 receptors leads to the rapid accumulation of cyclin B and tyrosine-hyperphosphorylated p34cdc2 (cdk1) kinase, indicative of cell cycle arrest at G2 phase PubMed
    Tat tat HIV-1 Tat induces a constitutive overexpression of cyclin B1 protein in human rhabdomyosarcoma cells PubMed
    Vpr vpr Rupture of HIV-1 Vpr-induced nuclear envelope herniations produces transient loss of the subcellular compartmentalization of Wee1, Cdc25C, cyclin B1, and presumably other soluble cellular components, resulting in their release into the cytoplasm PubMed
    vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inactivating cdc25C, the phosphatase that dephosphorylates and activates cdc2 PubMed
    vpr The human Vpr interacting protein (hVIP/MOV34) is a likely cellular cofactor for HIV-1 Vpr inactivation of the cdc2-cyclin B kinase complex and induction of cell cycle arrest PubMed
    vpr Data suggests that HIV-1 Vpr transactivation of the HIV-LTR promoter occurs through the inhibition of p300-associated cdc2-cyclin B kinase complex activity which enhances transcriptional activation by Rel A and p300 PubMed
    vpr Inactivation of the cdc2-cyclin B kinase complex by HIV-1 Vpr leads to the activation of Poly(A) polymerase PubMed
    vpr Inactivation of the cdc2-cyclin B kinase complex and arrest in the G2 phase of the cell cycle has been mapped to the C-terminus of HIV-1 Vpr, including amino acids 73, 80 and 84-96 PubMed
    vpr HIV-1 Vpr inactivates the cdc2-cyclin B kinase complex by inhibiting the dephosphorylation of cdc2 tyrosine 15, leading to arrest in the G2 phase of the cell cycle PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000005.8 FOXM1    BIND  PubMed FoxM1 interacts with the Cyclin B1 promoter. 
    NP_114172.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 is a tyrosine phosphoprotein that associates with Cyclin B1 
    NP_114172.1 NP_001752.1 CCNF    BIND  PubMed Cyclin F interacts with Cyclin B1. 
    NP_114172.1 NP_001246.1 CDC20    BIND  PubMed Cyclin B interacts with Cdc20. 
    NP_114172.1 NP_001777.1 CDK1    BIND  PubMed The cyclin-dependent kinase CDC2 interacts with cyclin B1. 
    NP_114172.1 NP_001777.1 CDK1    BIND  PubMed CDC2 (CDK1) interacts with CCNB1 (cyclin B1). This interaction was modeled on a demonstrated interaction between monkey CDC2 and human CCNB1. 
    NP_114172.1 NP_001777.1 CDK1    BIND  PubMed CCNB1 (CYCB) interacts with CDC2. 
    NP_114172.1 CDK1    BIND  PubMed Cyclin B1 interacts with Cdk1. 
    NP_114172.1 CDK1    BIND  PubMed CDC2 interacts with CCNB1 (cyclin B1) to form a complex. 
    NP_114172.1 CDK1    BIND  PubMed CCNB1 (cyclin B1) interacts with CDC2. 
    NP_114172.1 NP_000380.1 CDKN1A    BIND  PubMed CDKN1A (p21) interacts with CCNB1 (cyclin B1). 
    NP_114172.1 NP_001818.1 CKS2    BIND  PubMed Cks2 interacts with Cyclin B1. 
    NP_114172.1 NP_036423.3 ESPL1    BIND  PubMed Separase interacts with Cyclin B1. 
    NP_114172.1 NP_057347.2 FZR1    BIND  PubMed Cyclin B interacts with Cdh1. 
    NP_114172.1 NP_001915.1 GADD45A    BIND  PubMed Cyclin B1 interacts with Gadd45a. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45a from an unspecified species. 
    NP_114172.1 NP_006696.1 GADD45G    BIND  PubMed Cyclin B1 interacts with Gadd45g. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45g from an unspecified species. 
    NP_114172.1 NP_000255.1 PTCH1    BIND  PubMed Ptc1 interacts with Cyclin B1. 
    NP_114172.1 NP_057562.3 ZC3HC1    BIND  PubMed NIPA interacts with cyclin B1. This interaction was modelled on a demonstrated interaction between human NIPA and mouse cyclin B1. 
    NP_114172.1     BIND  PubMed SCF complex interacts with and ubiquitinates cyclin B1. 
    P14635 P38398 BRCA1    HPRD  PubMed  
    P14635 Q9NPC3 CCNB1IP1    HPRD  PubMed  
    P14635 P41002 CCNF    HPRD  PubMed  
    P14635 P30304 CDC25A    HPRD  PubMed  
    P14635 P30307 CDC25C    HPRD  PubMed  
    P14635 P06493 CDK1    HPRD  PubMed  
    P14635 P38936 CDKN1A    HPRD  PubMed  
    P14635 P46527 CDKN1B    HPRD  PubMed  
    P14635 P21333 FLNA    HPRD  PubMed  
    P14635 Q9UM11 FZR1    HPRD  PubMed  
    P14635 O75293 GADD45B    HPRD  PubMed  
    P14635 O95257 GADD45G    HPRD  PubMed  
    P14635 Q9UII4 HERC5    HPRD  PubMed  
    P14635 Q14643 ITPR1    HPRD  PubMed  
    P14635 Q92993 KAT5    HPRD  PubMed  
    P14635 P27816 MAP4    HPRD  PubMed  
    P14635 Q06413 MEF2C    HPRD  PubMed  
    P14635 Q9UQ07 MOK    HPRD  PubMed  
    P14635 Q96KB5 PBK    HPRD  PubMed  
    P14635 P12004 PCNA    HPRD  PubMed  
    P14635 Q13526 PIN1    HPRD  PubMed  
    P14635 Q99640 PKMYT1    HPRD  PubMed  
    P14635 P53350 PLK1    HPRD  PubMed  
    P14635 Q13635 PTCH1    HPRD  PubMed  
    P14635 P06454 PTMA    HPRD  PubMed  
    P14635 Q15311 RALBP1    HPRD  PubMed  
    P14635 Q13950 RUNX2    HPRD  PubMed  
    P14635 P37173 TGFBR2    HPRD  PubMed  
    P14635 Q92574 TSC1    HPRD  PubMed  
    BioGRID:107332 BioGRID:122229 ANAPC1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:115665 ANAPC10    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:119591 ANAPC11    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:117372 ANAPC13    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:125643 ANAPC16    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:118937 ANAPC2    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107332 BioGRID:118982 ANAPC4    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:119537 ANAPC5    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:119538 ANAPC7    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:111861 ARID4A    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:107140 BRCA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:107339 CCNF    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:114126 CDC14A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:114400 CDC16    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:107427 CDC20    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107332 BioGRID:114242 CDC23    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:107428 CDC25A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:107430 CDC25C    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:128878 CDC26    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:107431 CDC27    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:107332 BioGRID:107434 CDH1    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:107460 CDKN1A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:107582 CKS1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107332 BioGRID:107583 CKS2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107332 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107332 BioGRID:108203 E2F3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:222968 Espl1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:107332 BioGRID:117655 FBXO5    BioGRID  PubMed Biochemical Activity 
    BioGRID:107332 BioGRID:108594 FOXM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:119489 FZR1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:108014 GADD45A    BioGRID  PubMed Reconstituted Complex 
    NP_056490.1 GADD45B    BIND  PubMed Cyclin B1 interacts with Gadd45b. This interaction was modeled on a demonstrated interaction between human Cyclin B1 and Gadd45b from an unspecified species. 
    BioGRID:107332 BioGRID:110701 GADD45B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:116117 GADD45G    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:108868 GAPDH    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:119365 HERC5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:109275 HIST1H1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:110411 MGMT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:111142 PCNA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:111683 PSMD4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:111823 RAD23A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:116131 RALBP1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107332 BioGRID:112316 SET    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:112906 TGFBR2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:122034 TSPYL2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107332 BioGRID:109340 UBE2K    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107332 BioGRID:124656 UBE3D    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:107332 BioGRID:119007 UBQLN1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107332 BioGRID:125434 UHRF2    BioGRID  PubMed Affinity Capture-Western; Far Western 
    BioGRID:107332 BioGRID:119592 ZC3HC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of Cyclin B, organism-specific biosystemThe degradation of cyclin B1, which appears to occur at the mitotic spindle, is delayed until the metaphase /anaphase transition by the spindle assembly checkpoint and is required in order for sister...
    • APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemFollowing phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the ...
    • Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystem (from REACTOME)
      Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins, organism-specific biosystemAPC/C:Cdc20 is first activated at the prometaphase/metaphase transition through phosphorylation of core subunits of the APC/C by mitotic kinases as well as recruitment of the APC/C activator protein ...
    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Centrosome maturation, organism-specific biosystem (from REACTOME)
      Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
    • Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystem (from REACTOME)
      Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex, organism-specific biosystemDNA damage induced activation of the checkpoint kinases Chk1/Chk2(Cds1) results in the conversion and/or maintenance of CyclinB:Cdc2 complex in its Tyrosine 15 phosphorylated (inactive) state. Cdc2...
    • Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
      Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the pho...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
    • E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystem (from REACTOME)
      E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystemUnder specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk...
    • FOXM1 transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      FOXM1 transcription factor network, organism-specific biosystem
      FOXM1 transcription factor network
    • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
      FoxO family signaling, organism-specific biosystem
      FoxO family signaling
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • G2/M DNA damage checkpoint, organism-specific biosystem (from REACTOME)
      G2/M DNA damage checkpoint, organism-specific biosystemThroughout the cell cycle, the genome is constantly monitored for damage, resulting either from errors of replication, by-products of metabolism or through extrinsic sources such as ultra-violet or i...
    • G2/M DNA replication checkpoint, organism-specific biosystem (from REACTOME)
      G2/M DNA replication checkpoint, organism-specific biosystemThe G2/M DNA replication checkpoint ensures that mitosis is not initiated until DNA replication is complete. If replication is blocked, the DNA replication checkpoint signals to maintain Cyclin B - C...
    • G2/M Transition, organism-specific biosystem (from REACTOME)
      G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
    • Hedgehog Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Hedgehog Signaling Pathway, organism-specific biosystemThe Hedgehog proteins are a family of secreted ligands that include sonic hedgehog, Indian hedgehog and desert hedgehog in humans. Binding of Hedgehog ligands to their receptors, Patched 1 and 2, pre...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
      Mitotic G2-G2/M phases, organism-specific biosystem
      Mitotic G2-G2/M phases
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • PLK1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
      PLK1 signaling events, organism-specific biosystem
      PLK1 signaling events
    • Phosphorylation of Emi1, organism-specific biosystem (from REACTOME)
      Phosphorylation of Emi1, organism-specific biosystemThe phosphorylation of Emi1, which is required for its degradation in mitosis, appears to involve both Plk1 and Cdk1.
    • Phosphorylation of the APC/C, organism-specific biosystem (from REACTOME)
      Phosphorylation of the APC/C, organism-specific biosystemPhosphorylation of APC subunits is required for Cdc20 mediated activation by of the APC/C at the metaphase anaphase transition (Kramer et al., 2000). While the kinases responsible for phosphorylation...
    • Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
      Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
    • Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem (from REACTOME)
      Recruitment of NuMA to mitotic centrosomes, organism-specific biosystemThe NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essen...
    • Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
      Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • Validated targets of C-MYC transcriptional activation, organism-specific biosystem (from Pathway Interaction Database)
      Validated targets of C-MYC transcriptional activation, organism-specific biosystem
      Validated targets of C-MYC transcriptional activation
    • p53 signaling pathway, organism-specific biosystem (from KEGG)
      p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
    • p53 signaling pathway, conserved biosystem (from KEGG)
      p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    histone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    patched binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G2/M transition of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		  
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to fatty acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to iron(III) ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    cellular response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    digestive tract development IEA
    Inferred from Electronic Annotation
    more info
    		  
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle spindle checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic prometaphase IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic spindle stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    oocyte maturation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of cardiac muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of histone phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of mRNA 3'-end processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of chromosome condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    response to DDT IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to drug IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to toxin IEA
    Inferred from Electronic Annotation
    more info
    		  
    spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    tissue regeneration IEA
    Inferred from Electronic Annotation
    more info
    		  
    ventricular cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    condensed nuclear chromosome outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    soluble fraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    G2/mitotic-specific cyclin-B1
    Names
    G2/mitotic-specific cyclin-B1
    G2/mitotic-specific cyclin B1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031966.3 → NP_114172.1  G2/mitotic-specific cyclin-B1

      Status: REVIEWED

      Source sequence(s)
      AC010273, AI972071, BC006510, BI253686, BM979016
      Consensus CDS
      CCDS3997.1
      UniProtKB/Swiss-Prot
      P14635
      Related
      ENSP00000256442, OTTHUMP00000123478, ENST00000256442, OTTHUMT00000215084
      Conserved Domains (1) summary
      cd00043
      Location:201 – 290
      Blast Score: 203
      CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      68462913..68474072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      65418325..65429485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC010273.8 None
    genomic AC022107.8 (83185..83701) None
    genomic AY338491.1 AAP88038.1
    genomic CH471137.2 EAW51306.1
    genomic HH771226.1 CBX86318.1
    genomic S74452.1 AAD14154.1
    genomic U22364.1 AAD14818.1
    mRNA AI972071.1 None
    mRNA AK289431.1 BAF82120.1
    mRNA AM851053.1 CAO99273.1
    mRNA AY027761.1 AAK27417.1
    mRNA AY027762.1 AAK27418.1
    mRNA AY027763.1 AAK27419.1
    mRNA AY027764.1 AAK27420.1
    mRNA AY027765.1 AAK27421.1
    mRNA AY027767.1 AAK27422.1
    mRNA AY027768.1 AAK27423.1
    mRNA AY027769.1 AAK27424.1
    mRNA AY027770.1 AAK27425.1
    mRNA BC006510.2 AAH06510.1
    mRNA BI253686.1 None
    mRNA BM979016.1 None
    mRNA BT020128.1 AAV38930.1
    mRNA M25753.1 None
    other-genetic DQ892975.2 ABM83901.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14635.1 GenPept UniProtKB/Swiss-Prot:P14635
    Q5TZP9 GenPept UniProtKB/TrEMBL:Q5TZP9
    Q9BPX9 GenPept UniProtKB/TrEMBL:Q9BPX9
    Q9BWU7 GenPept UniProtKB/TrEMBL:Q9BWU7
    Q9BWU8 GenPept UniProtKB/TrEMBL:Q9BWU8
    Q9BWU9 GenPept UniProtKB/TrEMBL:Q9BWU9
    Q9BWV0 GenPept UniProtKB/TrEMBL:Q9BWV0
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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