CCNA1 cyclin A1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: CCNA1provided by HGNC
Official Full Name: cyclin A1provided by HGNC
Primary source: HGNC:1577
See related: Ensembl:ENSG00000133101; HPRD:04946; MIM:604036; Vega:OTTHUMG00000016733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Genomic context

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Location :: 13q12.3-q13

Sequence :: Chromosome: 13; NC_000013.10 (37005967..37017019)

See CCNA1 in Epigenomics, MapViewer

Chromosome 13 - NC_000013.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nuclear FoxO3a promotes cell cycle progression by transcriptional upregulation of cyclin A1, promoting proliferation of human anaplastic thyroid carcinoma cells.
Title: Foxo3a drives proliferation in anaplastic thyroid carcinoma through transcriptional regulation of cyclin A1: a paradigm shift that impacts current therapeutic strategies.
These findings indicate the possible involvement of cyclins A and E in the pathogenesis of malignant melanoma.
Title: Expression of cyclins A and E in melanocytic skin lesions and its correlation with some clinicopathologic features.
The organization of actin and cytokeratin cytoskeleton and the expression of TCTP, p53,cyclin A, RhoA and actin in HIO180 non-transformed ovarian epithelial cells, and OVCAR3 and SKOV3 ovarian epithelial cancer cells, was studied.
Title: Inverse relationship between TCTP/RhoA and p53 /cyclin A/actin expression in ovarian cancer cells.
Cyclin A1 as overexpressed in induced lpuripotent stem cells cells compared to embryonic stem cells, suggesting that during reprogramming, cyclin A1 protein expression levels are not set correctly.
Title: Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells.
Cyclin A1 is an important cell cycle regulator with age-related increased expression in tonsils of children. HPV16 induces overexpression of Cyclin A1 in HNSCC despite promoter methylation.
Title: Cyclin A1 shows age-related expression in benign tonsils, HPV16-dependent overexpression in HNSCC and predicts lower recurrence rate in HNSCC independently of HPV16.
Increased cyclin A1 in human bladder cancer cells may be regulated by activity of the USP2a deubiquitinase.
Title: The ubiquitin-specific protease USP2a enhances tumor progression by targeting cyclin A1 in bladder cancer.
Cyclin-A1 is the first prototypic leukemia-testis-antigen to be expressed in acute myeloid leukemia leukemic stem cells.
Title: Cyclin-A1 represents a new immunogenic targetable antigen expressed in acute myeloid leukemia stem cells with characteristics of a cancer-testis antigen.
Oxidized low density lipoprotein induces cyclin A synthesis in a process involving ERK, JNK and NFkappaB
Title: Oxidized low density lipoprotein induces cyclin A synthesis. Involvement of ERK, JNK and NFkappaB.
The integrated form of HPV might lead to CCNA1 promoter methylation in cervical cancer by some mechanisms.
Title: Human papillomavirus's physical state and cyclin A1 promoter methylation in cervical cancer.
CCNA1 methylation may play a crucial role in HPV16-induced carcinogenesis of HNSCC independently of p53
Title: Promoter methylation of cyclin A1 is associated with human papillomavirus 16 induced head and neck squamous cell carcinoma independently of p53 mutation.

Submit: New GeneRIF Correction See all (36)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003905.1	CAD91164.1	ARID2	BIND	PubMed	Cyclin A1 interacts with DKFZ.
NP_003905.1	NP_009227.1	BRCA1	BIND	PubMed	BRCA1 associates with Cyclin A
NP_003905.1	NP_001777.1	CDK1	BIND	PubMed	CCNA1 (CYCA) interacts with CDC2.
NP_003905.1		CDK2	BIND	PubMed	CCNA1 (CYCA) interacts with unspecified isoform of CDK2.
NP_003905.1	NP_000380.1	CDKN1A	BIND	PubMed	cyclin A1 interacts with p21.
NP_003905.1	NP_004055.1	CDKN1B	BIND	PubMed	cyclin A1 interacts with p27.
NP_003905.1	NP_005216.1	E2F1	BIND	PubMed	cyclin A1 interacts with E2F-1.
NP_003905.1	NP_006089.1	GNB2L1	BIND	PubMed	Cyclin A1 interacts with RACK1.
NP_003905.1	NP_004480.1	GPS2	BIND	PubMed	cyclin A1 interacts with GPS2.
NP_003905.1	NP_005316.1	HIST1H1A	BIND	PubMed	CCNA1 (CYCA) interacts with and phosporylates HIST1H1A (H1).
NP_003905.1	AAT09152.1	INCA1	BIND	PubMed	cyclin A1 interacts with INCA1.
NP_003905.1	AAT09158.1	KLHDC9	BIND	PubMed	cyclin A1 interacts with KARCA1.
NP_003905.1	AAT09159.1	PROCA1	BIND	PubMed	cyclin A1 interacts with PROCA1.
NP_003905.1	NP_002887.1	RBM4	BIND	PubMed	cyclin A1 interacts with RBM4.
NP_003905.1	NP_001460.1	XRCC6	BIND	PubMed	cyclin A1 interacts with Ku70.
P78396	Q68CP9	ARID2	HPRD	PubMed
P78396	P38398	BRCA1	HPRD	PubMed
P78396	Q8TDN4	CABLES1	HPRD	PubMed
P78396	P78396	CCNA1	HPRD	PubMed
P78396	P30304	CDC25A	HPRD	PubMed
P78396	P06493	CDK1	HPRD	PubMed
P78396	P24941	CDK2	HPRD	PubMed
P78396	P38936	CDKN1A	HPRD	PubMed
P78396	P46527	CDKN1B	HPRD	PubMed
P78396	Q01094	E2F1	HPRD	PubMed
P78396	P63244	GNB2L1	HPRD	PubMed
P78396	Q13227	GPS2	HPRD	PubMed
P78396	Inhibitor of CDK interacting with cyclin A1	INCA1	HPRD	PubMed
P78396	Kelch/ankyrin repeat containing cyclin A1 interacting protein	KLHDC9	HPRD	PubMed
P78396	P33991	MCM4	HPRD	PubMed
P78396	Q14566	MCM6	HPRD	PubMed
P78396	P10244	MYBL2	HPRD	PubMed
P78396	MGC39650	PROCA1	HPRD	PubMed
P78396	P06400	RB1	HPRD	PubMed
P78396	P28749	RBL1	HPRD	PubMed
P78396	Q08999	RBL2	HPRD	PubMed
P78396	Q9BWF3	RBM4	HPRD	PubMed
P78396	P12956	XRCC6	HPRD	PubMed
BioGRID:114417	BioGRID:107140	BRCA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:114417	CCNA1	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:107427	CDC20	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114417	BioGRID:107428	CDC25A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Co-crystal Structure; Co-fractionation; Co-purification; Reconstituted Complex; Two-hybrid
BioGRID:114417	BioGRID:107460	CDKN1A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:107461	CDKN1B	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:123555	CDT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:107582	CKS1B	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:107583	CKS2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:116183	COPS5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:116176	COPS6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:114032	CUL1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:114417	BioGRID:107903	CUX1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:119489	FZR1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:114417	BioGRID:115671	GNB2L1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114417	BioGRID:109132	GPS2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114417	BioGRID:109275	HIST1H1A	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:109264	HIST1H1B	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:129111	HIST1H2BA	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:132642	INCA1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114417	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:121775	KIAA1967	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:126019	KLHDC9	BioGRID	PubMed	Two-hybrid
BioGRID:114417	BioGRID:110333	MCC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:110341	MCM4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114417	BioGRID:110343	MCM6	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:110690	MYBL2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:201633	Mybl2	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:110924	NPAT	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:111105	PARK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:111260	PGR	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:114417	BioGRID:111493	PPP1CA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:127029	PROCA1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114417	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114417	BioGRID:111868	RBL1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:111869	RBL2	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:111871	RBM4	BioGRID	PubMed	Two-hybrid
BioGRID:114417	BioGRID:112037	RPA1	BioGRID	PubMed	Biochemical Activity
BioGRID:114417	BioGRID:31352	SIC1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:114417	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:114417	BioGRID:112550	SP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:114417	BioGRID:112592	SRC	BioGRID	PubMed	Two-hybrid
BioGRID:114417	BioGRID:205208	Skp2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:112899	TGFB1I1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:114553	USP2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114417	BioGRID:121664	VPS18	BioGRID	PubMed	Affinity Capture-MS
BioGRID:114417	BioGRID:108822	XRCC6	BioGRID	PubMed	Two-hybrid

Pathways from BioSystems

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AMPK signaling, organism-specific biosystem (from WikiPathways)
AMPK signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
C-MYB transcription factor network, organism-specific biosystem
C-MYB transcription factor network
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystemThe cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a c...
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystem (from REACTOME)
Cyclin A/B1 associated events during G2/M transition, organism-specific biosystemCell cycle progression is regulated by cyclin-dependent protein kinases at both the G1/S and the G2/M transitions by cyclin-dependent protein kinases. The G2/M transition is regulated through the pho...
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
DNA Replication, organism-specific biosystem (from REACTOME)
DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
G0 and Early G1, organism-specific biosystem (from REACTOME)
G0 and Early G1, organism-specific biosystemIn G0 and early G1 in quiescent cells, p130 (RBL2) bound to E2F4 or E2F5 and either DP1 or DP2, associates with the MuvB complex, forming an evolutionarily conserved DREAM complex, that represses tra...
G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
G1/S Transition, organism-specific biosystem (from REACTOME)
G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
G1/S-Specific Transcription, organism-specific biosystem (from REACTOME)
G1/S-Specific Transcription, organism-specific biosystemThe E2F family of transcription factors regulate the transition from the G1 to the S phase in the cell cycle. E2F activity is regulated by members of the retinoblastoma protein (pRb) family, resultin...
G2 Phase, organism-specific biosystem (from REACTOME)
G2 Phase, organism-specific biosystemThis is one of two 'gap' phases in the standard eukaryotic mitotic cell cycle. It is the interval between the completion of DNA synthesis and the beginning of mitosis. Protein synthesis occurs in th...
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
Gastric cancer network 1, organism-specific biosystem (from WikiPathways)
Gastric cancer network 1, organism-specific biosystemNetwork generated by mapping candidate oncogenes and tumor suppressor genes identified by integrated analysis of expression array and aCGH data. Networks generated by Ingenuity Pathway Analysis.
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
Mitotic G1-G1/S phases, organism-specific biosystem
Mitotic G1-G1/S phases
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystem
Mitotic G2-G2/M phases
Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
Orc1 removal from chromatin, organism-specific biosystem
Orc1 removal from chromatin
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes, organism-specific biosystem (from REACTOME)
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes, organism-specific biosystemCyclin A:Cdc2 complexes are detected in the nucleus earlier that cyclin B1:Cdc2 complexes and may play a role in the initial events in prophase. Inactivation of Cdc25B by proteasome-mediated degradat...
Progesterone-mediated oocyte maturation, organism-specific biosystem (from KEGG)
Progesterone-mediated oocyte maturation, organism-specific biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Progesterone-mediated oocyte maturation, conserved biosystem (from KEGG)
Progesterone-mediated oocyte maturation, conserved biosystemXenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division c...
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
Regulation of DNA replication, organism-specific biosystem (from REACTOME)
Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
Regulation of mitotic cell cycle, organism-specific biosystem
Regulation of mitotic cell cycle
Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
S Phase, organism-specific biosystem (from REACTOME)
S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continues,...
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
Switching of origins to a post-replicative state, organism-specific biosystem
Switching of origins to a post-replicative state
Synthesis of DNA, organism-specific biosystem (from REACTOME)
Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...

General gene information

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Markers

RH44746 (e-PCR)
- UniSTS:3713

PMC193706P2 (e-PCR)
- UniSTS:271757

RH71252 (e-PCR)
- UniSTS:63977

RH25577 (e-PCR)
- UniSTS:83702

Homology

Homologs of the CCNA1 gene: The CCNA1 gene is conserved in Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
cell division	IEA Inferred from Electronic Annotation more info
male meiosis I	TAS Traceable Author Statement more info	PubMed
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	TAS Traceable Author Statement more info
regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS Traceable Author Statement more info
spermatogenesis	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytosol	TAS Traceable Author Statement more info	PubMed
microtubule cytoskeleton	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: cyclin-A1

Names: cyclin-A1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111045.1 → NP_001104515.1 cyclin-A1 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a protein (isoform b) that is 1 amino acid shorter than isoform a.

Source sequence(s)

AA553454, BC036346, DC396283, DC411883

Consensus CDS

CCDS45030.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000396479, ENST00000418263

Conserved Domains (1) summary

cd00043
Location:242 – 317
Blast Score: 192

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_001111046.1 → NP_001104516.1 cyclin-A1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains a distinct 5' UTR and lacks an in-frame portion of the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.

Source sequence(s)

AA553454, AL359767, BG723613, CD171793, U66838

Consensus CDS

CCDS45031.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000400666, ENST00000440264

Conserved Domains (1) summary

cd00043
Location:199 – 274
Blast Score: 187

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_001111047.1 → NP_001104517.1 cyclin-A1 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains a distinct 5' UTR, lacks an in-frame portion of the 5' coding region, and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. Transcript variants 3 and 4 encode isoform c, which has a shorter N-terminus when compared to isoform a.

Source sequence(s)

AA553454, AL359767, BC036346, BG723613, DC395631

Consensus CDS

CCDS45031.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000409873, ENST00000449823

Conserved Domains (1) summary

cd00043
Location:199 – 274
Blast Score: 187

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...
NM_003914.3 → NP_003905.1 cyclin-A1 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AA553454, DC396283, DC411883, U66838

Consensus CDS

CCDS9357.1

UniProtKB/Swiss-Prot

P78396

Related

ENSP00000255465, OTTHUMP00000018259, ENST00000255465, OTTHUMT00000044514

Conserved Domains (1) summary

cd00043
Location:243 – 318
Blast Score: 192

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000013.10 Reference GRCh37.p10 Primary Assembly

Range

37005967..37017019

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000145.1 Alternate HuRef

Range

17817953..17828979

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018924.1 Alternate CHM1_1.0

Range

17950535..17961589

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01021358.1 (9570..20596)	None
genomic	AF124143.1	AAD26337.1
genomic	AL359767.13 (55535..66587)	None
genomic	AMYH01005038.1 (289404..300458)	None
genomic	CH471075.1	EAX08565.1
		EAX08566.1
genomic	HH771162.1	CBX86286.1
genomic	HH771214.1	CBX86312.1
mRNA	AA553454.1	None
mRNA	AK225146.1	None
mRNA	AK301897.1	BAH13579.1
mRNA	AK314261.1	BAG36926.1
mRNA	AK316392.1	BAH14763.1
mRNA	BC035479.1	None
mRNA	BC036346.1	AAH36346.1
mRNA	BG723613.1	None
mRNA	BT019577.1	AAV38384.1
mRNA	CD171793.1	None
mRNA	DC395631.1	None
mRNA	DC396283.1	None
mRNA	DC411883.1	None
mRNA	U66838.1	AAB49754.1
mRNA	U97680.1	AAB60863.1
other-genetic	AM393372.1	CAL38250.1
other-genetic	DQ891303.2	ABM82229.1
other-genetic	DQ894488.2	ABM85414.1