CCNA2 cyclin A2 [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: CCNA2provided by HGNC
Official Full Name: cyclin A2provided by HGNC
Primary source: HGNC:1578
See related: Ensembl:ENSG00000145386; HPRD:00453; MIM:123835; Vega:OTTHUMG00000133072
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCN1; CCNA
Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 4q25-q31

Sequence :: Chromosome: 4; NC_000004.11 (122737599..122745088, complement)

See CCNA2 in Epigenomics, MapViewer

Chromosome 4 - NC_000004.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data demonstrated that in addition to galectin-3, HK III and cyclin A profiles could be important biomarkers in predicting malignancy in follicular thyroid nodules.
Title: Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.
Cyclin A2 negatively controls cell motility by promoting RhoA activation, thus demonstrating a novel Cyclin A2 function in cytoskeletal rearrangements and cell migration.
Title: A novel function for Cyclin A2: control of cell invasion via RhoA signaling.
NF-Y binds to CCAAT sequences in the Cyclin A promoter, as well as to those in the promoters of cell cycle G2 regulators such as CDC2, Cyclin B and CDC25C.
Title: NF-Y binds to both G1- and G2-specific cyclin promoters; a possible role in linking CDK2/Cyclin A to CDK1/Cyclin B.
These data demonstrate that B55alpha acts to antagonize Cyclin A/Cdk-dependent activation of FoxM1, to ensure that FoxM1 activity is restricted to the G(2) phase of the cell cycle.
Title: Protein phosphatase 2A (B55α) prevents premature activation of forkhead transcription factor FoxM1 by antagonizing cyclin A/cyclin-dependent kinase-mediated phosphorylation.
The current results suggested that an SNP (rs769236) at the promoter of CCNA2 may be associated significantly with increased risk of colon, liver, and lung cancers.
Title: A functional single nucleotide polymorphism at the promoter region of cyclin A2 is associated with increased risk of colon, liver, and lung cancers.
The expression of mRNA and protein of Cyclin A in hypertrophic scar changes from high level to low level as the hypertrophic scar develops, while the expression of P21cip1 changes from low level to high level.
Title: [The expression of Cyclin A and p21cip1 in fibroblast of hypertrophic scar].
Low p16(Ink4a) expression, overexpression of p53, cytoplasmic p27(Kip1), and Cyclin A are predictive markers for shorter overall survival in ovarian carcinomas.
Title: Significance of cell cycle regulatory proteins as malignant and prognostic biomarkers in ovarian epithelial tumors.
cyclin A was strongly associated with the expression of cyclin E in invasive ductal breast carcinoma
Title: Expression of cell-cycle regulatory proteins BUBR1, MAD2, Aurora A, cyclin A and cyclin E in invasive ductal breast carcinomas.
Cdc20 requires APC3 and APC8 to bind and activate the APC/C when the spindle assembly checkpoint is satisfied, but only APC8 when active, and APC10 is crucial for the destruction of cyclin B1 and securin, but not cyclin A
Title: How APC/C-Cdc20 changes its substrate specificity in mitosis.
Homocysteine-induced differential activation of Ras/ERK and PI3K/Akt/p70S6K signaling pathways and consequent expression of cyclins A and D1 are dependent on beta1 integrin.
Title: Homocysteine induces smooth muscle cell proliferation through differential regulation of cyclins A and D1 expression.

Submit: New GeneRIF Correction See all (76)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA	PubMed

Go to the HIV-1, Human Protein Interaction Database

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
AF518006.1	NP_005216.1	E2F1	BIND	PubMed	E2F interacts with the CycA promoter and 5-prime UTR.
NC_000004.9	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with the Cyclin A promoter region.
NC_000004.9	NP_001941.2	E2F4	BIND	PubMed	E2F4 interacts with CCNA2 promoter.
NC_000004.9	NP_005602.2	RBL2	BIND	PubMed	p130 interacts with the Cyclin A promoter region.
NP_001228.1	NP_001777.1	CDK1	BIND	PubMed	The cyclin-dependent kinase CDC2 (cdc2) interacts with cyclin A2 (cyclin A).
NP_001228.1		CDK1	BIND	PubMed	CCNA2 (Cyclin A) interacts with CDC2.
NP_001228.1	NP_001789.2	CDK2	BIND	PubMed	Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_C).
NP_001228.1	NP_001789.2	CDK2	BIND	PubMed	Interaction between CDK2 (PDB ID: 1JST_C) and Cyclin A2 (PDB ID: 1JST_B).
NP_001228.1	NP_001789.2	CDK2	BIND	PubMed	Interaction between Cyclin A2 (PDB ID: 1JST_D) and CDK2 (PDB ID: 1JST_A).
NP_001228.1		CDK2	BIND	PubMed	Cdk2 interacts with Cyc A.
NP_001228.1		CDK2	BIND	PubMed	CDK2 interacts with CCNA2 (cyclin A) to form a complex.
NP_001228.1		CDK2	BIND	PubMed	Cyclin A interacts with cdk2.
NP_001228.1		CDK2	BIND	PubMed	CCNA2 (cyclin A) interacts with Cdk2.
NP_001228.1	NP_000380.1	CDKN1A	BIND	PubMed	cyclin A interacts with p21. This interaction was modeled on a demonstrated interaction between monkey cyclin A and monkey p21.
NP_001228.1	NP_000380.1	CDKN1A	BIND	PubMed	p21 interacts with cyclin A.
NP_001228.1	NP_000380.1	CDKN1A	BIND	PubMed	CDKN1A (p21) interacts with CCNA2 (cyclin A).
NP_001228.1	NP_004055.1	CDKN1B	BIND	PubMed	p27 interacts with Cyc A.
NP_001228.1	NP_004055.1	CDKN1B	BIND	PubMed	p27 interacts with cyclin A.
NP_001228.1	NP_004055.1	CDKN1B	BIND	PubMed	p27 interacts with cyclin A.
NP_001228.1	NP_003316.3	HIRA	BIND	PubMed	HIRA interacts with Cyclin A
NP_001228.1			BIND	PubMed	Cyclin A interacts with the APC complex.
P20248	P38398	BRCA1	HPRD	PubMed
P20248	P51587	BRCA2	HPRD	PubMed
P20248	P62324	BTG1	HPRD	PubMed
P20248	Q12834	CDC20	HPRD	PubMed
P20248	P30307	CDC25C	HPRD	PubMed
P20248	Q99741	CDC6	HPRD	PubMed
P20248	P06493	CDK1	HPRD	PubMed
P20248	P24941	CDK2	HPRD	PubMed
P20248	Q00526	CDK3	HPRD	PubMed
P20248	P38936	CDKN1A	HPRD	PubMed
P20248	P46527	CDKN1B	HPRD	PubMed
P20248	Q9H211	CDT1	HPRD	PubMed
P20248	Q01094	E2F1	HPRD	PubMed
P20248	O00716	E2F3	HPRD	PubMed
P20248	Q9UII4	HERC5	HPRD	PubMed
P20248	P54198	HIRA	HPRD	PubMed
P20248	Q13352	ITGB3BP	HPRD	PubMed
P20248	P10244	MYBL2	HPRD	PubMed
P20248	P06401	PGR	HPRD	PubMed
P20248	P06454	PTMA	HPRD	PubMed
P20248	P28749	RBL1	HPRD	PubMed
P20248	Q08999	RBL2	HPRD	PubMed
P20248	P63208	SKP1	HPRD	PubMed
P20248	Q13309	SKP2	HPRD	PubMed
P20248	P21675	TAF1	HPRD	PubMed
P20248	P04637	TP53	HPRD	PubMed
P20248	P17480	UBTF	HPRD	PubMed
BioGRID:107331	BioGRID:111861	ARID4A	BioGRID	PubMed	Biochemical Activity
BioGRID:107331	BioGRID:107140	BRCA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107331	BioGRID:107427	CDC20	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:107431	CDC27	BioGRID	PubMed	Biochemical Activity
BioGRID:107331	BioGRID:107426	CDC6	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107331	BioGRID:107420	CDK1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107331	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107331	BioGRID:107460	CDKN1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:107461	CDKN1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:107462	CDKN1C	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:123555	CDT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:107582	CKS1B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107331	BioGRID:126480	CKS1BP7	BioGRID	PubMed	Biochemical Activity
BioGRID:107331	BioGRID:107583	CKS2	BioGRID	PubMed	Biochemical Activity
BioGRID:107331	BioGRID:198624	Cdk1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107331	BioGRID:123857	DTNBP1	BioGRID	PubMed	Two-hybrid
BioGRID:107331	BioGRID:108201	E2F1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107331	BioGRID:111596	EIF2AK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107331	BioGRID:108528	FEN1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:119489	FZR1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:119365	HERC5	BioGRID	PubMed	Reconstituted Complex
BioGRID:107331	BioGRID:116992	ITGB3BP	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:107331	BioGRID:114375	KAT2B	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:111040	ORC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:111041	ORC2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:111142	PCNA	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:111868	RBL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107331	BioGRID:111869	RBL2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107331	BioGRID:112037	RPA1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107331	BioGRID:31352	SIC1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:112393	SKP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107331	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107331	BioGRID:113010	TP53	BioGRID	PubMed	Reconstituted Complex
BioGRID:107331	BioGRID:117577	TRAF3IP1	BioGRID	PubMed	Two-hybrid
BioGRID:107331	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:107331	BioGRID:125434	UHRF2	BioGRID	PubMed	Affinity Capture-Western; Far Western
BioGRID:107331	BioGRID:119697	UIMC1	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info
protein kinase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
Ras protein signal transduction	IEP Inferred from Expression Pattern more info	PubMed
cell division	IEA Inferred from Electronic Annotation more info
mitosis	IEA Inferred from Electronic Annotation more info
mitotic cell cycle	TAS Traceable Author Statement more info
mitotic cell cycle G2/M transition DNA damage checkpoint	TAS Traceable Author Statement more info	PubMed
positive regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
regulation of cyclin-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
female pronucleus	IEA Inferred from Electronic Annotation more info
male pronucleus	IEA Inferred from Electronic Annotation more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: cyclin-A2

Names: cyclin-A2; cyclin-A

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001237.3 → NP_001228.1 cyclin-A2

Status: VALIDATED

Source sequence(s)

BC021067, DA748568

Consensus CDS

CCDS3723.1

UniProtKB/Swiss-Prot

P20248

Related

ENSP00000274026, OTTHUMP00000164087, ENST00000274026, OTTHUMT00000256712

Conserved Domains (2) summary

cd00043
Location:210 – 299
Blast Score: 216

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...

COG5333
Location:172 – 432
Blast Score: 118

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000004.11 Reference GRCh37.p5 Primary Assembly

Range

122737599..122745088, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000136.1 Alternate HuRef

Range

118464283..118471772, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC079341.6	AAY40969.1
genomic	AF518006.1	AAM54042.1
genomic	CH471056.2	EAX05246.1
genomic	X68303.1	CAA48375.1
mRNA	AK291931.1	BAF84620.1
mRNA	AW276578.1	None
mRNA	BC104783.1	AAI04784.1
mRNA	BC104787.1	AAI04788.1
mRNA	CR407692.1	CAG28620.1
mRNA	DA748568.1	None
mRNA	X51688.1	CAA35986.1