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    PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast) [ Homo sapiens ]

    Gene ID: 8899, updated on 11-May-2012
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    Summary

    Official Symbol
    PRPF4Bprovided by HGNC
    Official Full Name
    PRP4 pre-mRNA processing factor 4 homolog B (yeast)provided by HGNC
    Primary source
    HGNC:17346
    Locus tag
    RP5-1013A10.2
    See related
    Ensembl:ENSG00000112739; HPRD:09087; MIM:602338; Vega:OTTHUMG00000014157
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PR4H; PRP4; PRP4H; PRP4K; dJ1013A10.1; KIAA0536
    Summary
    Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs). [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    6p25.2
    Sequence :
    Chromosome: 6; NC_000006.11 (4021569..4065217)
    See PRPF4B in Epigenomics, MapViewer

    Chromosome 6 - NC_000006.11Genomic Context describing neighboring genes Neighboring gene teratocarcinoma-derived growth factor 1 pseudogene 4 Neighboring gene glutaredoxin 3 pseudogene Neighboring gene family with sequence similarity 217, member A Neighboring gene chromosome 6 open reading frame 201 Neighboring gene enoyl-CoA delta isomerase 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation. Schneider M, et al. Nat Struct Mol Biol, 2010 Feb. PMID 20118938.
    4. Changed profile of splicing regulator genes expression in response to exercise. Tonevitsky EA, et al. Bull Exp Biol Med, 2009 Jun. PMID 19902070.
    5. The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor. Crawford NP, et al. J Biol Chem, 2009 Oct 16. PMID 19710015.

    See all (29) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The authors provide evidence that PRP6 and PRP31 are directly phosphorylated by human PRP4 kinase (PRP4K) concomitant with their incorporation into B complexes.
      Title: Human PRP4 kinase is required for stable tri-snRNP association during spliceosomal B complex formation.
    2. Short-term exercise resulted in a significant increase of mRNA expression of genes encoding proteins involved in the formation of precatalytic splisosome: PRPF4B.
      Title: Changed profile of splicing regulator genes expression in response to exercise.
    3. PRP4, a serine/threonine protein kinase, is identified as a Kruppel-like factor 13 (KLF13)-binding protein; PRP4 phosphorylates KLF13
      Title: Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
    4. Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
      Title: Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes.
    5. interacts specifically with HIV-2 gag
      Title: Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q13523 Q12988 HSPB3    HPRD  PubMed  
    Q13523 Q9Y2Y9 KLF13    HPRD  PubMed  
    Q13523 Q9H307 PNN    HPRD  PubMed  
    Q13523 Q9H1D9 POLR3F    HPRD  PubMed  
    Q13523 Q07955 SRSF1    HPRD  PubMed  
    Q13523 P61981 YWHAG    HPRD  PubMed  
    BioGRID:114416 BioGRID:114470 HSPB3    BioGRID  PubMed Two-hybrid 
    BioGRID:114416 BioGRID:111412 PNN    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:114416 BioGRID:115866 POLR3F    BioGRID  PubMed Two-hybrid 
    BioGRID:114416 BioGRID:114576 PRPF4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:116125 RNPS1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:116708 RRP1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:215383 Rrp1b    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:115939 USP39    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114416 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the PRPF4B gene: The PRPF4B gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, , N.crassa, and A.thaliana.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • mRNA processing, organism-specific biosystem (from WikiPathways)
      mRNA processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    protein phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    serine/threonine-protein kinase PRP4 homolog
    Names
    serine/threonine-protein kinase PRP4 homolog
    PRP4 kinase
    protein-serine/threonine kinase
    PRP4 pre-mRNA-processing factor 4 homolog
    dJ1013A10.1 (PRP4 protein kinase homolog)
    NP_003904.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003913.4 → NP_003904.3  serine/threonine-protein kinase PRP4 homolog

      Status: REVIEWED

      Source sequence(s)
      AL033383, AY029347, CN314758, CN314761
      Consensus CDS
      CCDS4488.1
      UniProtKB/Swiss-Prot
      Q13523
      Related
      ENSP00000337194, OTTHUMP00000195201, ENST00000337659, OTTHUMT00000314018
      Conserved Domains (2) summary
      smart00220
      Location:694 – 1003
      Blast Score: 538
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:694 – 1003
      Blast Score: 477
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000006.11 Reference GRCh37.p5 Primary Assembly

      Range
      4021569..4065217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000138.1 Alternate HuRef

      Range
      3898364..3941580
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_176800.2: Suppressed sequence

      Description
      NM_176800.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL033383.26 CAI42121.1
    genomic AL138831.12 CAI20480.1
    genomic CH471087.1 EAW55146.1
      EAW55147.1
      EAW55148.1
      EAW55149.1
      EAW55150.1
      EAW55151.1
    mRNA AB011108.1 BAA25462.1
    mRNA AF283465.1 AAM19101.1
    mRNA AK291244.1 BAF83933.1
    mRNA AK303047.1 BAG64167.1
    mRNA AY029347.1 AAK38155.1
    mRNA BC009844.2 AAH09844.1
    mRNA BC034969.1 AAH34969.1
    mRNA CN314758.1 None
    mRNA CN314761.1 None
    mRNA U48736.1 AAB03268.1
    mRNA Z25435.1 CAA80922.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13523.3 GenPept UniProtKB/Swiss-Prot:Q13523
    Q15456 GenPept UniProtKB/TrEMBL:Q15456
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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