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gltA type II citrate synthase [ Helicobacter pylori J99 ]

Gene ID: 889056, updated on 12-Apr-2014
Gene symbol
gltA
Gene description
type II citrate synthase
Locus tag
jhp0022
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Helicobacter pylori J99 (strain: J99)
Lineage
Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales; Helicobacteraceae; Helicobacter
Sequence:
NC_000921.1 (26315..27595, complement)

NC_000921.1Genomic Context describing neighboring genes Neighboring gene lipid A phosphoethanolamine transferase Neighboring gene hypothetical protein Neighboring gene isocitrate dehydrogenase Neighboring gene hypothetical protein Neighboring gene dethiobiotin synthetase

Related articles in PubMed

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Names
type II citrate synthase
NP_222744.1
  • type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000921.1 

    Range
    26315..27595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_222744.1 type II citrate synthase [Helicobacter pylori J99]

    See proteins identical to NP_222744.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9ZN37
    Conserved Domains (2) summary
    cd06114
    Location:16425
    Blast Score: 1760
    EcCS_like; Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS ...
    COG0372
    Location:25425
    Blast Score: 1230
    GltA; Citrate synthase [Energy production and conversion]