Display Settings:

Format

Send to:

Choose Destination

MCM3AP minichromosome maintenance complex component 3 associated protein [ Homo sapiens (human) ]

Gene ID: 8888, updated on 5-Jul-2015
Official Symbol
MCM3APprovided by HGNC
Official Full Name
minichromosome maintenance complex component 3 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:6946
See related
Ensembl:ENSG00000160294; HPRD:04483; MIM:603294; Vega:OTTHUMG00000090630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GANP; SAC3; MAP80
Summary
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]
Orthologs
See MCM3AP in Epigenomics, MapViewer
Location:
21q22.3
Exon count:
31
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 21 NC_000021.9 (46235125..46286559, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (47655047..47706211, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene spermatogenesis and centriole associated 1-like Neighboring gene lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) Neighboring gene MCM3AP antisense RNA 1 Neighboring gene chromosome 21 open reading frame 58 Neighboring gene ybeY metallopeptidase (putative) Neighboring gene pericentrin Neighboring gene ribosomal protein L18a pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of minichromosome maintenance complex component 3 associated protein (MCM3AP) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Encapsidation of GANP into virions requires the CA region of HIV-1 Gag and GANP and is associated with HIV-1 genomic RNA PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ44336, FLJ45306, KIAA0572

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
transferase activity, transferring acyl groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication TAS
Traceable Author Statement
more info
PubMed 
immune system process IEA
Inferred from Electronic Annotation
more info
 
mRNA transport IEA
Inferred from Electronic Annotation
more info
 
protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
germinal-center associated nuclear protein
Names
80 kDa MCM3-associated protein
MCM3 acetylating protein
MCM3 acetyltransferase
MCM3 import protein
MCM3 minichromosome maintenance deficient 3 associated protein
germinal center-associated nuclear protein
germinal-centre associated nuclear protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033881.1 RefSeqGene

    Range
    4929..55198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003906.4NP_003897.2  germinal-center associated nuclear protein

    See identical proteins and their annotated locations for NP_003897.2

    Status: REVIEWED

    Source sequence(s)
    AA659734, AJ010089, AL079407, BC104958
    Consensus CDS
    CCDS13734.1
    UniProtKB/Swiss-Prot
    O60318
    Related
    ENSP00000291688, ENST00000291688
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p2 Primary Assembly

    Range
    46235125..46286559
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261204.3XP_005261261.1  

    See identical proteins and their annotated locations for XP_005261261.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region
  2. XM_005261206.3XP_005261263.1  

    See identical proteins and their annotated locations for XP_005261263.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region
  3. XM_006724064.2XP_006724127.1  

    See identical proteins and their annotated locations for XP_006724127.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region
  4. XM_005261205.2XP_005261262.1  

    See identical proteins and their annotated locations for XP_005261262.1

    UniProtKB/Swiss-Prot
    O60318
    Related
    ENSP00000380820, OTTHUMP00000115776, ENST00000397708, OTTHUMT00000207254
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region
  5. XM_005261203.3XP_005261260.1  

    See identical proteins and their annotated locations for XP_005261260.1

    UniProtKB/Swiss-Prot
    O60318
    Conserved Domains (5) summary
    smart00360
    Location:440490
    RRM; RNA recognition motif
    cd12443
    Location:435506
    RRM_MCM3A_like; RNA recognition motif in 80 kDa MCM3-associated protein (Map80) and similar proteins
    pfam03399
    Location:686910
    SAC3_GANP; SAC3/GANP/Nin1/mts3/eIF-3 p25 family
    pfam10075
    Location:802932
    PCI_Csn8; COP9 signalosome, subunit CSN8
    pfam13634
    Location:9140
    Nucleoporin_FG; Nucleoporin FG repeat region

RNA

  1. XR_937577.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018932.2 Alternate CHM1_1.1

    Range
    47215873..47266253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)