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    ZNF259 zinc finger protein 259 [ Homo sapiens (human) ]

    Gene ID: 8882, updated on 5-May-2013
    Official Symbol
    ZNF259provided by HGNC
    Official Full Name
    zinc finger protein 259provided by HGNC
    Primary source
    HGNC:13051
    See related
    HPRD:04877; MIM:603901
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZPR1
    Location :
    11q23.3
    Sequence :
    Chromosome: 11; NC_000011.9 (116649276..116658739, complement)
    See ZNF259 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 pseudogene 15 Neighboring gene BUD13 homolog (S. cerevisiae) Neighboring gene apolipoprotein A-V Neighboring gene apolipoprotein A-IV

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A census of human soluble protein complexes. Havugimana PC, et al. Cell, 2012 Aug 31. PMID 22939629.
    2. Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. Inouye M, et al. PLoS Genet, 2012. PMID 22916037.
    3. A high-throughput approach for measuring temporal changes in the interactome. Kristensen AR, et al. Nat Methods, 2012 Sep. PMID 22863883.
    4. A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides. Braun TR, et al. PLoS One, 2012. PMID 22623978.
    5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. Udeshi ND, et al. Mol Cell Proteomics, 2012 May. PMID 22505724.

    See all (41) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Significant associations of two SNPs (rs964184 and rs12286037) from ZNF259 with triglyceride levels in an Asian Indian cohort.
      Title: A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.
    2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
      Title: Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
    6. ZPR1 deficiency causes disruption of survival motor neurons and histone gene-specific transcription factor NPAT localization within the nucleus, blocks S phase progression, and arrests cells in both the G1 and G2 phases of the cell cycle.
      Title: Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    NHGRI GWAS Catalog

    show more
    Products Interactant Other Gene Complex Source Pubs Description
    O75312 Q96SN8 CDK5RAP2    HPRD  PubMed  
    O75312 P68104 EEF1A1    HPRD  PubMed  
    O75312 P00533 EGFR    HPRD  PubMed  
    O75312 Q6EEV6 SUMO4    HPRD  PubMed  
    BioGRID:114401 BioGRID:115404 ACTR2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115403 ACTR3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:109503 AGFG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115987 AHCYL1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:106712 ALAD    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:117348 ARIH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115400 ARPC4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:107009 ATP6V1B2    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:114710 ATP6V1F    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:107049 BAG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:114392 CDC123    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:120873 CDK5RAP2    BioGRID  PubMed Two-hybrid 
    BioGRID:114401 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:114401 BioGRID:121955 FKBP10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:108570 FKBP1A    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:109426 HNRNPF    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:109530 HSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:117168 HSPBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:117304 HYPK    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:122313 KLC2    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:122098 LEPRE1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:110208 LPP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:110496 MPP3    BioGRID  PubMed Two-hybrid 
    BioGRID:114401 BioGRID:126402 NUDCD2    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:114049 OGT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:120779 OSGEP    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115852 PAICS    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:118854 PHPT1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:119524 PPME1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:111502 PPP1R7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:121820 RPRD1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115384 SNUPN    BioGRID  PubMed Reconstituted Complex 
    BioGRID:114401 BioGRID:126716 SRXN1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:115788 SSSCA1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113722 STAM    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:112686 SULT1A1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:132223 SUMO4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:112702 SURF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:117549 SZRD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:117572 TES    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:114132 THOC5    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:123138 THOC7    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:112937 TJP1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:115352 TOM1L1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:115487 TXNDC9    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:115365 UBA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:114401 BioGRID:113167 UBE2A    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113169 UBE2D1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113170 UBE2D2    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113180 UBE2L3    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113184 UBE2V2    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:115566 UBE4B    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:124418 UBL7    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:121223 UBQLN4    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:119239 UBXN1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:117507 UBXN7    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:119577 UFC1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:119616 UFM1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:118893 UHRF1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:114930 VPS26A    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:114901 VPS4B    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:115684 YAP1    BioGRID  PubMed Co-fractionation 
    BioGRID:114401 BioGRID:113569 ZYX    BioGRID  PubMed Co-fractionation 
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...

    Markers

    Genotypes

    Homology

    Clone Names

    • MGC110983

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cell proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Preferred Names
    zinc finger protein ZPR1
    Names
    zinc finger protein ZPR1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003904.3 → NP_003895.1  zinc finger protein ZPR1

      Status: PROVISIONAL

      Source sequence(s)
      BC017349
      Consensus CDS
      CCDS8375.1
      UniProtKB/Swiss-Prot
      O75312
      Conserved Domains (2) summary
      pfam03367
      Location:48 – 207
      Blast Score: 632
      zf-ZPR1; ZPR1 zinc-finger domain
      cl00771
      Location:259 – 449
      Blast Score: 382
      COG1779; C4-type Zn-finger protein [General function prediction only]

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p10 Primary Assembly

      Range
      116649276..116658739, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      112581245..112590732, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018922.1 Alternate CHM1_1.0

      Range
      116512954..116522417, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01039747.1 (9739..17392) None
    genomic ABBA01039748.1 None
    genomic AMYH01004054.1 (83842..93305) None
    genomic AP006216.1 (67607..77070) None
    genomic CH471065.1 EAW67267.1
      EAW67268.1
    mRNA AF019767.1 AAC33514.1
    mRNA AK301227.1 BAG62800.1
    mRNA BC004256.1 AAH04256.1
    mRNA BC011929.2 None
    mRNA BC012162.1 AAH12162.1
    mRNA BC017349.2 AAH17349.1
    mRNA BC017380.2 AAH17380.1
    mRNA BC111028.1 AAI11029.1
    mRNA BT006642.1 AAP35288.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75312.1 GenPept UniProtKB/Swiss-Prot:O75312

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

      General information

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