katG catalase-peroxidase-peroxynitritase T KATG [Mycobacterium tuberculosis H37Rv] - Gene

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Summary

Gene symbol: katG
Gene description: catalase-peroxidase-peroxynitritase T KATG
Locus tag: Rv1908c
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mycobacterium tuberculosis H37Rv (strain: H37Rv)
Lineage: Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex

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Genomic context

Sequence :: NC_000962.2 (2153889..2156111, complement)

NC_000962.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Hotspot mutations within the katG 315 and inhA-15 genes can be used as genetic markers for detection of isoniazid resistance.
Title: Molecular characterization of isoniazid-resistant Mycobacterium tuberculosis isolates from Xi'an, China.
Downregulation of katG expression is associated with isoniazid resistance.
Title: Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
9 novel KatG mutants with a single-amino-acid substitution were found; all mutants had lower INH oxidase activities than wild type and each had various levels of activity; isolates with mutations with relatively low activity had high-level INH resistance
Title: Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis.
the catalytic properties of the wild-type enzyme to 23 KatG mutants which have been associated with isoniazid resistance in clinical M. tuberculosis isolates were compared.
Title: Isoniazid-resistance conferring mutations in Mycobacterium tuberculosis KatG: catalase, peroxidase, and INH-NADH adduct formation activities.
Drug resistance in M tuberculosis is due to mutations in relatively restricted regions of the genome: rpoB for RIF, katG and inhA for INH, embB for ethambutol, pncA for pyrazinamide, and so on.
Title: Clinical efficacy of direct DNA sequencing analysis on sputum specimens for early detection of drug-resistant Mycobacterium tuberculosis in a clinical setting.
the analysis of region 1 results in an increase in the rate at which the genotypic diagnosis of INH resistance-arising from mutations, deletions or insertions in the katG gene-is reached.
Title: Isoniazid-resistant Mycobacterium tuberculosis strains arising from mutations in two different regions of the katG gene.
An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG).
Title: An oxyferrous heme/protein-based radical intermediate is catalytically competent in the catalase reaction of Mycobacterium tuberculosis catalase-peroxidase (KatG).
Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant
Title: Role of the oxyferrous heme intermediate and distal side adduct radical in the catalase activity of Mycobacterium tuberculosis KatG revealed by the W107F mutant.
Multidrug resistance of MBT to rifampicin and isoniazid was mainly due to the combined mutation Ser531 --> Leu in the rpoB gene and to the mutation Ser315 --> Thr in the katG gene.
Title: [Practical value of the TB-biochip MDR test system in the rapid identification of multidrug-resistant M. tuberculosis strains].
Direct evidence reveals that lung and blood T-cell responses to KatG in two cohorts of sarcoidosis patients are regulated in a manner expected for a candidate pathogenic antigen.
Title: T cell responses to mycobacterial catalase-peroxidase profile a pathogenic antigen in systemic sarcoidosis.

Submit: New GeneRIF Correction See all (21)

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General gene information

Pathways from BioSystems

Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
Methane metabolism, organism-specific biosystem (from KEGG)
Methane metabolism, organism-specific biosystemMethane is metabolized principally by methanotrophs and the methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a ...
Methane metabolism, conserved biosystem (from KEGG)
Methane metabolism, conserved biosystemMethane is metabolized principally by methanotrophs and the methanogens in the global carbon cycle. Methanotrophs consume methane as the only source of carbon, while methanogens produce methane as a ...
Microbial metabolism in diverse environments, organism-specific biosystem (from KEGG)
Microbial metabolism in diverse environments, organism-specific biosystem
Microbial metabolism in diverse environments
Phenylalanine metabolism, organism-specific biosystem (from KEGG)
Phenylalanine metabolism, organism-specific biosystem
Phenylalanine metabolism
Phenylalanine metabolism, conserved biosystem (from KEGG)
Phenylalanine metabolism, conserved biosystem
Phenylalanine metabolism
Tryptophan metabolism, organism-specific biosystem (from KEGG)
Tryptophan metabolism, organism-specific biosystem
Tryptophan metabolism
Tryptophan metabolism, conserved biosystem (from KEGG)
Tryptophan metabolism, conserved biosystem
Tryptophan metabolism
superoxide radicals degradation, organism-specific biosystem (from BIOCYC)
superoxide radicals degradation, organism-specific biosystem
superoxide radicals degradation

Miscellaneous features

Loc: c2155310-2155287 PS00017 ATP/GTP-binding site motif A (P-loop)
Loc: c2155817-2155782 PS00436 Peroxidases active site signature

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General protein information

Names: catalase-peroxidase-peroxynitritase T KATG

NP_216424.1

EC 1.11.1.6

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000962.2

Range

2153889..2156111, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_216424.1 katG gene product [Mycobacterium tuberculosis H37Rv]

UniProtKB/Swiss-Prot

Q08129

Conserved Domains (3) summary

cd00649
Location:32 – 436
Blast Score: 2035

catalase_peroxidase_1; N-terminal catalytic domain of catalase-peroxidases.

cd08200
Location:440 – 736
Blast Score: 1407

catalase_peroxidase_2; C-terminal non-catalytic domain of catalase-peroxidases.

PRK15061
Location:15 – 740
Blast Score: 3750

PRK15061; catalase/hydroperoxidase HPI(I); Provisional