KSR1 kinase suppressor of ras 1 [Homo sapiens] - Gene

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Summary

Official Symbol: KSR1provided by HGNC
Official Full Name: kinase suppressor of ras 1provided by HGNC
Primary source: HGNC:6465
See related: Ensembl:ENSG00000141068; MIM:601132; Vega:OTTHUMG00000132051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: KSR; RSU2

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Genomic context

Location :: 17q11.2

Sequence :: Chromosome: 17; NC_000017.10 (25799036..25950718)

See KSR1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1
Title: Simulating EGFR-ERK signaling control by scaffold proteins KSR and MP1 reveals differential ligand-sensitivity co-regulated by Cbl-CIN85 and endophilin.
Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
Title: Genetic disruption of the scaffolding protein, Kinase Suppressor of Ras 1 (KSR1), differentially regulates GM-CSF-stimulated hyperproliferation in hematopoietic progenitors expressing activating PTPN11 mutants D61Y and E76K.
KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels
Title: KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.
Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.
Title: Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia cells.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
DC-SIGN was constitutively associated with a signalosome complex consisting of the scaffold proteins LSP1, KSR1 and CNK and the kinase Raf-1.
Title: Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori.
KSR1 regulated the threshold required for MAPK activation in T cells without affecting the nature of the response.
Title: KSR1 modulates the sensitivity of mitogen-activated protein kinase pathway activation in T cells without altering fundamental system outputs.
Down-regulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.
Title: Downregulation of KSR1 in pancreatic cancer xenografts by antisense oligonucleotide correlates with tumor drug uptake.
human 14-3-3gamma binds to the ERK1/2 molecular scaffold KSR1, which is mediated by the C-terminal stretch of 14-3-3gamma
Title: The functional interaction of 14-3-3 proteins with the ERK1/2 scaffold KSR1 occurs in an isoform-specific manner.
Human KSR1 proteins promote assembly of multivalent Raf.MEK complexes that are required for c-Raf kinase activation and functional coupling of active kinases to downstream substrates.
Title: IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs
Q8IVT5	P29323	EPHB2	HPRD	PubMed
Q8IVT5	Q02750	MAP2K1	HPRD	PubMed
Q8IVT5	P28482	MAPK1	HPRD	PubMed
Q8IVT5	P27448	MARK3	HPRD	PubMed
Q8IVT5	P15531	NME1	HPRD	PubMed
Q8IVT5	P04049	RAF1	HPRD	PubMed
Q8IVT5	P63104	YWHAZ	HPRD	PubMed

Function	Evidence Code	Pubs
ATP binding	NAS Non-traceable Author Statement more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
Ras protein signal transduction	NAS Non-traceable Author Statement more info	PubMed
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
protein phosphorylation	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
intracellular	NAS Non-traceable Author Statement more info
membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: kinase suppressor of Ras 1

Names: kinase suppressor of Ras 1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_014238.1 → NP_055053.1 kinase suppressor of Ras 1

Status: VALIDATED

Source sequence(s)

BC037586, BC042106, BI829205, BX396814, U43586

UniProtKB/TrEMBL

A8MY87

UniProtKB/Swiss-Prot

Q8IVT5

Related

ENSP00000268763, ENST00000268763

Conserved Domains (4) summary

cd00029
Location:211 – 253
Blast Score: 106

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd00180
Location:498 – 740
Blast Score: 334

PKc; Catalytic domain of Protein Kinases

pfam07714
Location:476 – 740
Blast Score: 396

Pkinase_Tyr; Protein tyrosine kinase

pfam13543
Location:1 – 31
Blast Score: 91

KSR1-SAM; SAM like domain present in kinase suppressor RAS 1

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

25799036..25950718

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

22006077..22157867

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC015688.11 (80120..107219)	None
genomic	AC069366.8	None
genomic	CH471159.1	EAW51034.1
		EAW51035.1
mRNA	AK130719.1	BAC85413.1
mRNA	BC035488.1	None
mRNA	BC037586.1	None
mRNA	BC042106.1	AAH42106.1
mRNA	BI829205.1	None
mRNA	BX396814.2	None
mRNA	U43586.1	AAC50354.1
other-genetic	BC167812.1	AAI67812.1