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WISP1 WNT1 inducible signaling pathway protein 1 [ Homo sapiens (human) ]

Gene ID: 8840, updated on 8-May-2016
Official Symbol
WISP1provided by HGNC
Official Full Name
WNT1 inducible signaling pathway protein 1provided by HGNC
Primary source
HGNC:HGNC:12769
See related
Ensembl:ENSG00000104415 HPRD:16019; MIM:603398
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CCN4; WISP1c; WISP1i; WISP1tc
Summary
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. It is expressed at a high level in fibroblast cells, and overexpressed in colon tumors. The encoded protein binds to decorin and biglycan, two members of a family of small leucine-rich proteoglycans present in the extracellular matrix of connective tissue, and possibly prevents the inhibitory activity of decorin and biglycan in tumor cell proliferation. It also attenuates p53-mediated apoptosis in response to DNA damage through activation of the Akt kinase. It is 83% identical to the mouse protein at the amino acid level. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2011]
Orthologs
Location:
8q24.22
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (133191039..133231690)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (134203282..134243933)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene thyroglobulin Neighboring gene microRNA 7848 Neighboring gene Src-like-adaptor Neighboring gene uncharacterized LOC105375769 Neighboring gene uncharacterized LOC102723635 Neighboring gene N-myc downstream regulated 1 Neighboring gene ribosomal protein L32 pseudogene 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ14388

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
insulin-like growth factor binding IEA
Inferred from Electronic Annotation
more info
 
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cell death IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
proteinaceous extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
WNT1-inducible-signaling pathway protein 1
Names
CCN family member 4
CTC-458A3.8
WNT1 induced secreted protein 1
Wnt-1 inducible signaling pathway protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029529.1 RefSeqGene

    Range
    5001..45652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001204869.1NP_001191798.1  WNT1-inducible-signaling pathway protein 1 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the coding region, as compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AB034725, AF192304, AI347990, AY196488, BX476382
    Consensus CDS
    CCDS56555.1
    UniProtKB/Swiss-Prot
    O95388
    Related
    ENSP00000427744, OTTHUMP00000226719, ENST00000517423, OTTHUMT00000378797
    Conserved Domains (1) summary
    pfam00219
    Location:54101
    IGFBP; Insulin-like growth factor binding protein
  2. NM_001204870.1NP_001191799.1  WNT1-inducible-signaling pathway protein 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001191799.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three internal exons in the coding region, as compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF192304, AI347990, AY196486, BX476382
    Consensus CDS
    CCDS56556.1
    UniProtKB/Swiss-Prot
    O95388
    Related
    ENSP00000429185, OTTHUMP00000226718, ENST00000519433, OTTHUMT00000378796
    Conserved Domains (1) summary
    cl21545
    Location:35117
    GHB_like; Glycoprotein hormone beta chain homologues
  3. NM_003882.3NP_003873.1  WNT1-inducible-signaling pathway protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the full length protein (isoform 1).
    Source sequence(s)
    AF192304, AI347990, AK293031
    Consensus CDS
    CCDS6371.1
    UniProtKB/Swiss-Prot
    O95388
    Related
    ENSP00000250160, OTTHUMP00000226716, ENST00000250160, OTTHUMT00000378794
    Conserved Domains (3) summary
    smart00214
    Location:123181
    VWC; von Willebrand factor (vWF) type C domain
    pfam00090
    Location:220259
    TSP_1; Thrombospondin type 1 domain
    pfam00219
    Location:54101
    IGFBP; Insulin-like growth factor binding protein
  4. NM_080838.2NP_543028.1  WNT1-inducible-signaling pathway protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_543028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, as compared to variant 1. Isoform 2 encoded by this variant thus lacks a von Willbrand type C module that is thought to participate in protein complex formation. This variant is overexpressed in scirrhous carcinomas.
    Source sequence(s)
    AB034725, AF192304, AI347990, BX476382, DN997366
    Consensus CDS
    CCDS6372.1
    UniProtKB/Swiss-Prot
    O95388
    Related
    ENSP00000220856, OTTHUMP00000226720, ENST00000220856, OTTHUMT00000378798
    Conserved Domains (2) summary
    pfam00090
    Location:133172
    TSP_1; Thrombospondin type 1 domain
    pfam00219
    Location:54101
    IGFBP; Insulin-like growth factor binding protein

RNA

  1. NR_037944.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks internal two exons, resulting in an immature translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.
    Source sequence(s)
    AF192304, AI347990, AK301508

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    133191039..133231690
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517358.1XP_011515660.1  

    Conserved Domains (3) summary
    smart00214
    Location:45103
    VWC; von Willebrand factor (vWF) type C domain
    pfam00090
    Location:142181
    TSP_1; Thrombospondin type 1 domain
    cl21545
    Location:202284
    GHB_like; Glycoprotein hormone beta chain homologues
  2. XM_006716680.2XP_006716743.1  

    Conserved Domains (2) summary
    pfam00090
    Location:5594
    TSP_1; Thrombospondin type 1 domain
    cl21545
    Location:115197
    GHB_like; Glycoprotein hormone beta chain homologues
  3. XM_011517359.1XP_011515661.1  

    Conserved Domains (2) summary
    pfam00090
    Location:3776
    TSP_1; Thrombospondin type 1 domain
    cl21545
    Location:97179
    GHB_like; Glycoprotein hormone beta chain homologues

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    134244050..134284955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)