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FGF16 fibroblast growth factor 16 [ Homo sapiens (human) ]

Gene ID: 8823, updated on 12-May-2016
Official Symbol
FGF16provided by HGNC
Official Full Name
fibroblast growth factor 16provided by HGNC
Primary source
HGNC:HGNC:3672
See related
Ensembl:ENSG00000196468 HPRD:04764; MIM:300827; MIM:309630
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MF4; FGF-16
Summary
This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]
Orthologs
Location:
Xq13
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (77447675..77456522)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (76709645..76712013)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373254 Neighboring gene SPRY domain containing 7 pseudogene Neighboring gene ATRX, chromatin remodeler Neighboring gene fatty acid binding protein 5 pseudogene 15 Neighboring gene magnesium transporter 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity TAS
Traceable Author Statement
more info
 
Ras guanyl-nucleotide exchange factor activity TAS
Traceable Author Statement
more info
 
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate 3-kinase activity TAS
Traceable Author Statement
more info
 
protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
fibroblast growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
metabolic process TAS
Traceable Author Statement
more info
PubMed 
organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol phosphorylation IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-mediated signaling TAS
Traceable Author Statement
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of brown fat cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphatidylinositol 3-kinase signaling TAS
Traceable Author Statement
more info
 
NOT regulation of sprouting angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
response to temperature stimulus TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
intracellular IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fibroblast growth factor 16
Names
metacarpal 4-5 fusion

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034050.1 RefSeqGene

    Range
    5001..13848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003868.2NP_003859.1  fibroblast growth factor 16

    See identical proteins and their annotated locations for NP_003859.1

    Status: REVIEWED

    Source sequence(s)
    AB009391, AC243316
    Consensus CDS
    CCDS75996.1
    UniProtKB/Swiss-Prot
    O43320
    Related
    ENSP00000399324, OTTHUMP00000015342, ENST00000439435, OTTHUMT00000036814
    Conserved Domains (1) summary
    cd00058
    Location:63190
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    77447675..77456522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    76602325..76604695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)