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    DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 [ Homo sapiens ]

    Gene ID: 8798, updated on 11-May-2012
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    Summary

    Official Symbol
    DYRK4provided by HGNC
    Official Full Name
    dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4provided by HGNC
    Primary source
    HGNC:3095
    See related
    Ensembl:ENSG00000010219; HPRD:10926; MIM:609181; Vega:OTTHUMG00000168204
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Dual-specificity kinases, such as DYRK4, play key roles in cell proliferation, survival, and development (Zhang et al., 2005 [PubMed 15607427]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    12p13.32
    Sequence :
    Chromosome: 12; NC_000012.11 (4699244..4723041)
    See DYRK4 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene chromosome 12 open reading frame 4 Neighboring gene RAD51 associated protein 1 Neighboring gene A kinase (PRKA) anchor protein 3 Neighboring gene RAB5A, member RAS oncogene family pseudogene Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. Persaud A, et al. Mol Syst Biol, 2009. PMID 19953087.
    2. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.
    3. The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice. Sacher F, et al. Mol Cell Endocrinol, 2007 Mar 15. PMID 17292540.
    4. DYRK gene structure and erythroid-restricted features of DYRK3 gene expression. Zhang D, et al. Genomics, 2005 Jan. PMID 15607427.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Dyrk4 is a testis-specific kinase with a very restricted expression to stage VIII postmeiotic spermatids.
      Title: The expression of the testis-specific Dyrk4 kinase is highly restricted to step 8 spermatids but is not required for male fertility in mice.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:114326 BioGRID:110811 NEDD4    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Potential readthrough

    Included gene: NDUFA9

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding NAS
    Non-traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein serine/threonine kinase activity NAS
    Non-traceable Author Statement
    more info
    		  
    protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    protein phosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 4
    Names
    dual specificity tyrosine-phosphorylation-regulated kinase 4
    NP_003836.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003845.1 → NP_003836.1  dual specificity tyrosine-phosphorylation-regulated kinase 4

      Status: PROVISIONAL

      Source sequence(s)
      BC031244
      Consensus CDS
      CCDS8530.1
      UniProtKB/Swiss-Prot
      Q9NR20
      Related
      ENSP00000441755, OTTHUMP00000238291, ENST00000540757, OTTHUMT00000398780
      Conserved Domains (2) summary
      smart00220
      Location:104 – 400
      Blast Score: 629
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl09925
      Location:104 – 399
      Blast Score: 503
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p5 Primary Assembly

      Range
      4699244..4723041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      4555938..4579734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC005832.1 (81231..105028) None
    genomic CH471116.2 EAW88841.1
      EAW88842.1
    mRNA AF263541.1 AAF91393.1
    mRNA AK292322.1 BAF85011.1
    mRNA AK298979.1 BAG61073.1
    mRNA AK303744.1 BAG64716.1
    mRNA AK308260.1 None
    mRNA AK308702.1 None
    mRNA BC031244.1 AAH31244.1
    mRNA GU139739.1 ADC33153.1
    mRNA GU139740.1 ADC33154.1
    mRNA GU139741.1 ADC33155.1
    mRNA GU139742.1 ADC33156.1
    mRNA GU139743.1 None
    mRNA GU139744.1 ADC33157.1
    mRNA Y09305.1 CAA70488.1
    mRNA GU139745.1 None
    other-genetic DQ891520.2 ABM82446.1
    other-genetic DQ894710.2 ABM85636.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NR20.2 GenPept UniProtKB/Swiss-Prot:Q9NR20
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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