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TNFRSF10A tumor necrosis factor receptor superfamily, member 10a [ Homo sapiens (human) ]

Gene ID: 8797, updated on 17-May-2015
Official Symbol
TNFRSF10Aprovided by HGNC
Official Full Name
tumor necrosis factor receptor superfamily, member 10aprovided by HGNC
Primary source
HGNC:HGNC:11904
See related
HPRD:04679; MIM:603611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR4; APO2; CD261; TRAILR1; TRAILR-1
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Orthologs
See TNFRSF10A in MapViewer
Location:
8p21
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (23191457..23225167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (23048970..23082680, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC254896 Neighboring gene tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain Neighboring gene tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain Neighboring gene ribosomal protein L23a pseudogene 55 Neighboring gene uncharacterized LOC389641 Neighboring gene charged multivesicular body protein 7

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.
NHGRI GWA Catalog
Seven new loci associated with age-related macular degeneration.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 results in the upregulation of TRAIL death receptor expression and acquired sensitivity to TRAIL mediated cell death; this effect of gp120 requires the chemokine coreceptor CXCR4, but not CCR5 or the CD4 receptor PubMed
env Gp120-induced M-CSF downregulates the TRAIL receptor TRAIL-R1/DR4 and upregulates the anti-apoptotic genes Bfl-1 and Mcl-1 PubMed

Go to the HIV-1, Human Interaction Database

  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • CASP8 activity is inhibited, organism-specific biosystem (from REACTOME)
    CASP8 activity is inhibited, organism-specific biosystemCell death triggered by extrinsic stimuli via death receptors or toll-like receptors (e.g., TLR3, TLR4) may result in either apoptosis or regulated necrosis (necroptosis) (Holler N et al. 2000; Kalai...
  • Caspase activation via extrinsic apoptotic signalig pathway, organism-specific biosystem (from REACTOME)
    Caspase activation via extrinsic apoptotic signalig pathway, organism-specific biosystemKnown as the "death receptor pathway" the extrinsic or caspase 8/10 dependent pathway is activated by ligand binding. The "death receptors" are specialized cell-surface receptors including Fas/CD95, ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Death Receptor Signalling, organism-specific biosystem (from REACTOME)
    Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
  • Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
    Dimerization of procaspase-8, organism-specific biosystemProcaspase-8 monomers undergo dimerization. The dimerization event occurs at death-inducing signaling complex (DISC) and results in a reposition of the procaspase-8 inter-subunit linker to become acc...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Ligand-dependent caspase activation, organism-specific biosystem (from REACTOME)
    Ligand-dependent caspase activation, organism-specific biosystemCaspase-8 is synthesized as zymogen (procaspase-8) and is formed from procaspase-8 as a cleavage product. However, the cleavage itself appears not to be sufficient for the formation of an active casp...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
    Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • RIPK1-mediated regulated necrosis, organism-specific biosystem (from REACTOME)
    RIPK1-mediated regulated necrosis, organism-specific biosystemReceptor-interacting kinase protein 1 (RIPK1) and RIPK3-dependent necrosis is called necroptosis or programmed necrosis. The kinase activities of RIPK1 and RIPK3 are essential for the necroptotic cel...
  • Regulated Necrosis, organism-specific biosystem (from REACTOME)
    Regulated Necrosis, organism-specific biosystemNecrosis has traditionally been considered as a passive, unregulated cell death. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by genetically controlled and h...
  • Regulation by c-FLIP, organism-specific biosystem (from REACTOME)
    Regulation by c-FLIP, organism-specific biosystemc-FLIP proteins (CASP8 and FADD-like apoptosis regulators or c-FLICE inhibitory proteins) are death effector domain (DED)-containing proteins that are recruited to the death-inducing signaling comple...
  • Regulation of necroptotic cell death, organism-specific biosystem (from REACTOME)
    Regulation of necroptotic cell death, organism-specific biosystemA regulated balance between cell survival and cell death is essential for normal development and homeostasis of multicellular organisms. Defects in control of this balance may contribute to autoimmu...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • TRAIL signaling, organism-specific biosystem (from REACTOME)
    TRAIL signaling, organism-specific biosystemTumor necrosis factor-related apoptosis-inducing ligand or Apo 2 ligand (TRAIL/Apo2L) is a member of the tumor necrosis factor (TNF) family. This group of apoptosis induction pathways all work throug...
  • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
    TRAIL signaling pathway, organism-specific biosystem
    TRAIL signaling pathway
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC9365

Gene Ontology Provided by GOA

Function Evidence Code Pubs
TRAIL binding NAS
Non-traceable Author Statement
more info
PubMed 
death receptor activity TAS
Traceable Author Statement
more info
PubMed 
protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
TRAIL-activated apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
activation of NF-kappaB-inducing kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
extrinsic apoptotic signaling pathway via death domain receptors NAS
Non-traceable Author Statement
more info
PubMed 
necroptotic process TAS
Traceable Author Statement
more info
 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process TAS
Traceable Author Statement
more info
 
programmed cell death TAS
Traceable Author Statement
more info
 
programmed necrotic cell death TAS
Traceable Author Statement
more info
 
regulation of extrinsic apoptotic signaling pathway via death domain receptors TAS
Traceable Author Statement
more info
 
regulation of necrotic cell death TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IC
Inferred by Curator
more info
PubMed 
intracellular NAS
Non-traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
tumor necrosis factor receptor superfamily member 10A
Names
tumor necrosis factor receptor superfamily member 10A
TNF-related apoptosis-inducing ligand receptor 1
TRAIL receptor 1
TRAIL-R1
cytotoxic TRAIL receptor
death receptor 4
tumor necrosis factor receptor superfamily member 10a variant 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032107.1 RefSeqGene

    Range
    5001..38711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003844.3NP_003835.3  tumor necrosis factor receptor superfamily member 10A

    See identical proteins and their annotated locations for NP_003835.3

    Status: REVIEWED

    Source sequence(s)
    BC012866, CN423254, DB101031
    Consensus CDS
    CCDS6039.1
    UniProtKB/Swiss-Prot
    O00220
    Conserved Domains (3) summary
    smart00208
    Location:190229
    TNFR; Tumor necrosis factor receptor / nerve growth factor receptor repeats
    cd00185
    Location:116208
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cd08315
    Location:367454
    Death_TRAILR_DR4_DR5; Death domain of Tumor necrosis factor-Related Apoptosis-Inducing Ligand Receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    23191457..23225167
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    23251086..23284807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)