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    TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain [ Homo sapiens ]

    Gene ID: 8794, updated on 21-Jan-2012
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    Summary

    Official Symbol
    TNFRSF10Cprovided by HGNC
    Official Full Name
    tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domainprovided by HGNC
    Primary source
    HGNC:11906
    Locus tag
    UNQ321/PRO366
    See related
    Ensembl:ENSG00000173535; HPRD:04681; MIM:603613; Vega:OTTHUMG00000097844
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LIT; DCR1; TRID; CD263; TRAILR3; TRAIL-R3; DCR1-TNFR
    Summary
    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    8p22-p21
    Sequence :
    Chromosome: 8; NC_000008.10 (22960327..22974950)
    See TNFRSF10C in Epigenomics, MapViewer

    Chromosome 8 - NC_000008.10Genomic Context describing neighboring genes Neighboring gene Rho-related BTB domain containing 2 Neighboring gene tumor necrosis factor receptor superfamily, member 10b Neighboring gene tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain pseudogene Neighboring gene tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain Neighboring gene tumor necrosis factor receptor superfamily, member 10a Neighboring gene ribosomal protein L23a pseudogene 55

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2. Chamuleau ME, et al. Leuk Res, 2011 Jun. PMID 21281967.
    2. TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis. Bisgin A, et al. BMC Musculoskelet Disord, 2010 Aug 27. PMID 20799941.
    3. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. Lee KM, et al. Am J Hematol, 2010 Aug. PMID 20568250.
    4. TRAIL upregulates decoy receptor 1 and mediates resistance to apoptosis in insulin-secreting INS-1 cells. Kang S, et al. Biochem Biophys Res Commun, 2010 Jun 4. PMID 20451496.
    5. New genetic associations detected in a host response study to hepatitis B vaccine. Davila S, et al. Genes Immun, 2010 Apr. PMID 20237496.

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data show that about 20% of AML patients highly expressed decoy receptor TRAIL-R3, which was strongly correlated to a shortened overall survival.
      Title: High TRAIL-R3 expression on leukemic blasts is associated with poor outcome and induces apoptosis-resistance which can be overcome by targeting TRAIL-R2.
    2. Decoy receptors DcR1 and DcR2 on CD8+ T cells, but not on CD4-positive T cells, are positively correlated with patients' DAS scores.
      Title: TRAIL death receptor-4, decoy receptor-1 and decoy receptor-2 expression on CD8+ T cells correlate with the disease severity in patients with rheumatoid arthritis.
    3. Results suggest that DcR1 expression occurs in a subset of endometrial carcinomas and may contribute to resistance to TRAIL-induced apoptosis.
      Title: DcR1 expression in endometrial carcinomas.
    4. Low DCR1 is associated with non-small cell lung cancer.
      Title: Cytotoxic effects of camptothecin and cisplatin combined with tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in a model of primary culture of non-small cell lung cancer.
    5. Liver metastases with low DcR1/TNFRSF10C mRNA expression were more likely to present with extrahepatic metastases
      Title: Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level.
    6. inactivation of TNFRSF10C by chromosomal deletion and promoter methylation may play an important role in prostate cancer development
      Title: Genetic and epigenetic inactivation of TNFRSF10C in human prostate cancer.
    7. These data strongly support a recent proposal that a segment at 8p21.3 contains crucial prostate cancer tumor suppressors.
      Title: Protein phosphatase and TRAIL receptor genes as new candidate tumor genes on chromosome 8p in prostate cancer.
    8. TRAILR3 (TNF-related apoptosis inducing ligand receptor 3) levels were significantly higher in lung parenchyma in subjects with emphysema
      Title: Increased p53 level, Bax/Bcl-x(L) ratio, and TRAIL receptor expression in human emphysema.
    9. p53 negatively regulates oxaliplatin-mediated TRAIL-induced apoptotic activity through DcR1 upregulation.
      Title: P53-mediated upregulation of DcR1 impairs oxaliplatin/TRAIL-induced synergistic anti-tumour potential in colon cancer cells.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut.
    Submit: New GeneRIF Correction See all (22)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Treatment of CD4+ T cells with HIV-1 gp120 results in the upregulation of TRAIL death receptor expression and acquired sensitivity to TRAIL mediated cell death; this effect of gp120 requires the chemokine coreceptor CXCR4, but not CCR5 or the CD4 receptor PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NC_000008.9 NP_000537.2 TP53    BIND  PubMed TP53 (p53) interacts with TNFRSF10C (TRAIL-R3) gene. 
    O14798 P02647 APOA1    HPRD  PubMed  
    O14798 Q8N5W9 FAM101B    HPRD  PubMed  
    O14798 Q6UWE0 LRSAM1    HPRD  PubMed  
    O14798 P62834 RAP1A    HPRD  PubMed  
    O14798 Q9Y2P4 SLC27A6    HPRD  PubMed  
    O14798 P50591 TNFSF10    HPRD  PubMed  
    O14798 Q9UKY1 ZHX1    HPRD  PubMed  
    BioGRID:114322 BioGRID:106832 APOA1    BioGRID  PubMed Two-hybrid 
    BioGRID:114322 BioGRID:131787 FAM101B    BioGRID  PubMed Two-hybrid 
    BioGRID:114322 BioGRID:118790 SLC27A6    BioGRID  PubMed Two-hybrid 
    BioGRID:114322 BioGRID:116406 ZHX1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Pathways from BioSystems

    • Apoptosis, organism-specific biosystem (from KEGG)
      Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Apoptosis, conserved biosystem (from KEGG)
      Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
      Direct p53 effectors, organism-specific biosystem
      Direct p53 effectors
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Natural killer cell mediated cytotoxicity, organism-specific biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, organism-specific biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • Natural killer cell mediated cytotoxicity, conserved biosystem (from KEGG)
      Natural killer cell mediated cytotoxicity, conserved biosystemNatural killer (NK) cells are lymphocytes of the innate immune system that are involved in early defenses against both allogeneic (nonself) cells and autologous cells undergoing various forms of stre...
    • TRAIL signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      TRAIL signaling pathway, organism-specific biosystem
      TRAIL signaling pathway

    Clone Names

    • MGC149501, MGC149502

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    TRAIL binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane signaling receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    anchored to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    tumor necrosis factor receptor superfamily member 10C
    Names
    tumor necrosis factor receptor superfamily member 10C
    decoy receptor 1
    cytotoxic TRAIL receptor-3
    lymphocyte inhibitor of TRAIL
    decoy TRAIL receptor without death domain
    antagonist decoy receptor for TRAIL/Apo-2L
    TNF-related apoptosis-inducing ligand receptor 3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003841.3 → NP_003832.2  tumor necrosis factor receptor superfamily member 10C precursor

      Status: REVIEWED

      Source sequence(s)
      AF012536, AF014794, DC380668
      Consensus CDS
      CCDS6037.1
      UniProtKB/Swiss-Prot
      O14798
      Related
      ENSP00000349324, OTTHUMP00000123527, ENST00000356864, OTTHUMT00000215134
      Conserved Domains (2) summary
      cd00185
      Location:41 – 129
      Blast Score: 153
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
      cl12111
      Location:111 – 149
      Blast Score: 101
      TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000008.10 Reference GRCh37.p5 Primary Assembly

      Range
      22960327..22974950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000140.1 Alternate HuRef

      Range
      21504474..21519103
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC107959.8 (165614..180130) None
    genomic AF524869.1 AAM82564.1
    genomic CH471080.2 EAW63638.1
    genomic GM840261.1 CAT16333.1
    genomic HB475040.1 CBA12840.1
    mRNA AF012536.1 AAB67104.1
    mRNA AF012629.1 AAB67110.1
    mRNA AF014794.1 AAC05593.1
    mRNA AF016267.1 AAB81181.1
    mRNA AF020502.1 AAB71413.1
    mRNA AF033854.1 AAB87506.1
    mRNA AK298664.1 BAG60832.1
    mRNA AK298718.1 BAH12853.1
    mRNA AK313213.1 BAG36028.1
    mRNA AY358281.1 AAQ88648.1
    mRNA BC017852.1 AAH17852.1
    mRNA BC125041.1 AAI25042.1
    mRNA BC125042.1 AAI25043.1
    mRNA BG545631.1 None
    mRNA CR541857.1 CAG46655.1
    mRNA DC380668.1 None
    Protein Accession Links
    GenePept Link UniProtKB Link
    O14798.3 GenPept UniProtKB/Swiss-Prot:O14798
    Q05D71 GenPept UniProtKB/TrEMBL:Q05D71
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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