ADAM9 ADAM metallopeptidase domain 9 [Homo sapiens] - Gene

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Summary

Official Symbol: ADAM9provided by HGNC
Official Full Name: ADAM metallopeptidase domain 9provided by HGNC
Primary source: HGNC:216
See related: Ensembl:ENSG00000168615; HPRD:04091; MIM:602713; Vega:OTTHUMG00000159783
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MCMP; MDC9; CORD9; Mltng; KIAA0021
Summary: This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene interacts with SH3 domain-containing proteins, binds mitotic arrest deficient 2 beta protein, and is also involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor. Several alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2010]

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Genomic context

Location :: 8p11.22

Sequence :: Chromosome: 8; NC_000008.10 (38854505..38962780)

See ADAM9 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

ADAM10 activity is regulated by inhibition of ADAM9, and this regulation may be used to control shedding of amyloid precursor protein by enhancing alpha-secretase activity, a key regulatory step in the etiology of Alzheimer disease
Title: ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
ADAM-9 expression plays an important role in mediating cell-cell contacts between fibroblasts and melanoma cells and that these interactions contribute to proteolytic activities required during invasion of melanoma cells.
Title: The disintegrin-like and cysteine-rich domains of ADAM-9 mediate interactions between melanoma cells and fibroblasts.
The data of this suggested that promoter polymorphisms which regulate ADAM9 transcription are protective against SAD.
Title: Promoter polymorphisms which regulate ADAM9 transcription are protective against sporadic Alzheimer's disease.
ADAM9 plays a crucial role in prostate cancer progression and therapeutic resistance in part by altering E-cadherin and integrin expression.
Title: Inhibition of ADAM9 expression induces epithelial phenotypic alterations and sensitizes human prostate cancer cells to radiation and chemotherapy.
Secreted variants of ADAM9 are a key determinant in manifestation of aggressive migratory phenotypes associated with breast cancer progression.
Title: Secreted and membrane-bound isoforms of protease ADAM9 have opposing effects on breast cancer cell migration.
disintegrin and metalloprotease-9 is overexpressed in hepatocellular carcinoma and can be used as a prognostic marker
Title: Increased expression of a disintegrin and metalloprotease-9 in hepatocellular carcinoma: implications for tumor progression and prognosis.
is expressed in adenoid cystic carcinoma-associated metastasis
Title: RNAi-mediated ADAM9 gene silencing inhibits metastasis of adenoid cystic carcinoma cells.
Data show that the expression levels MMP1, MMP9, ADAM9 and TIMP3 were altered in drug-resistant sublines.
Title: Gene expression analysis of drug-resistant MCF-7 cells: implications for relation to extracellular matrix proteins.
the role of the disintegrin domain of the human ADAM9 (ADAM9D) on the adhesion of breast tumor cells and platelets to collagen I
Title: Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions.
Experiments revealed that ADAM9 and ADAM10, but not ADAM17, are involved in the shedding of PrP(C) and that ADAM9 exerts its effect on PrP(C) shedding via ADAM10.
Title: Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.

Submit: New GeneRIF Correction See all (30)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_003807.1	NP_006332.2	MAD2L2	BIND	PubMed	MAD2 beta interacts with MDC9.
Q13443	P26006	ITGA3	HPRD	PubMed
Q13443	P23229	ITGA6	HPRD	PubMed
Q13443	P06756	ITGAV	HPRD	PubMed
Q13443	Q9UI95	MAD2L2	HPRD	PubMed
Q13443	Q05655	PRKCD	HPRD	PubMed
Q13443	SH3 domain protein D19	SH3D19	HPRD	PubMed
Q13443	Q9Y371	SH3GLB1	HPRD	PubMed
Q13443	Q9Y5X1	SNX9	HPRD	PubMed
Q13443	P01375	TNF	HPRD	PubMed
BioGRID:114290	BioGRID:107434	CDH1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114290	BioGRID:115722	MAD2L2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:114290	BioGRID:111566	PRKCD	BioGRID	PubMed	Affinity Capture-Western
	XP_098238.8	SH3D19	BIND	PubMed	An unspecified isoform of ADAM9 binds to Eve-1d.
BioGRID:114290	BioGRID:112353	SH3GL2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114290	BioGRID:119535	SNX9	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114290	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
			BIND	PubMed	An unspecified isoform of ADAM9 binds to Eve-1c.

Function	Evidence Code	Pubs
SH3 domain binding	IPI Inferred from Physical Interaction more info	PubMed
SH3 domain binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
collagen binding	IMP Inferred from Mutant Phenotype more info	PubMed
integrin binding	IC Inferred by Curator more info	PubMed
integrin binding	IDA Inferred from Direct Assay more info	PubMed
integrin binding	IPI Inferred from Physical Interaction more info	PubMed
laminin binding	IMP Inferred from Mutant Phenotype more info	PubMed
metal ion binding	IEA Inferred from Electronic Annotation more info
metalloendopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
metallopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
peptidase activity	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
PMA-inducible membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
PMA-inducible membrane protein ectodomain proteolysis	TAS Traceable Author Statement more info	PubMed
activation of MAPKK activity	IDA Inferred from Direct Assay more info	PubMed
cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
cell-cell adhesion mediated by integrin	IEP Inferred from Expression Pattern more info	PubMed
cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
integrin-mediated signaling pathway	IC Inferred by Curator more info	PubMed
keratinocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
membrane protein ectodomain proteolysis	IDA Inferred from Direct Assay more info	PubMed
monocyte activation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of cell adhesion mediated by integrin	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of keratinocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of macrophage fusion	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of membrane protein ectodomain proteolysis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IEA Inferred from Electronic Annotation more info
response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
response to glucocorticoid stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
response to manganese ion	IMP Inferred from Mutant Phenotype more info	PubMed
response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
cell surface	ISS Inferred from Sequence or Structural Similarity more info	PubMed
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	IDA Inferred from Direct Assay more info	PubMed
extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed
integral to membrane	IEA Inferred from Electronic Annotation more info
intrinsic to external side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: disintegrin and metalloproteinase domain-containing protein 9

Names: disintegrin and metalloproteinase domain-containing protein 9; cone rod dystrophy 9; myeloma cell metalloproteinase; cellular disintegrin-related protein; ADAM metallopeptidase domain 9 (meltrin gamma); metalloprotease/disintegrin/cysteine-rich protein 9

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016335.1 RefSeqGene

Range

5001..113276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003816.2 → NP_003807.1 disintegrin and metalloproteinase domain-containing protein 9 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the protein coding transcript.

Source sequence(s)

AV708278, U41766

Consensus CDS

CCDS6112.1

UniProtKB/Swiss-Prot

Q13443

Related

ENSP00000419446, OTTHUMP00000216481, ENST00000487273, OTTHUMT00000357291

Conserved Domains (4) summary

cd04269
Location:212 – 404
Blast Score: 654

ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...

pfam01562
Location:43 – 163
Blast Score: 462

Pep_M12B_propep; Reprolysin family propeptide

cl10507
Location:423 – 498
Blast Score: 310

Disintegrin; Disintegrin

cl15456
Location:500 – 636
Blast Score: 496

ADAM_CR; ADAM cysteine-rich

RNA

NR_027638.1 RNA Sequence

Description

Transcript Variant: This variant (3) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.

Source sequence(s)

AC105091, AV708278, BC027996, BC126406, BC143923
NR_027639.1 RNA Sequence

Description

Transcript Variant: This variant (4) omits a coding exon resulting in a frameshift and premature stop codon compared to variant 1. This suggests that the transcript is subject to nonsense-mediated decay (NMD) and therefore a predicted protein is not annotated.

Source sequence(s)

AC105091, AV708278, BC027996, BC143924
NR_027878.1 RNA Sequence

Description

Transcript Variant: This variant (2) lacks an exon in the 3' coding region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AV708278, BC027996, BC143923

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

38854505..38962780

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

37387348..37495887

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001005845.1: Suppressed sequence

Description

NM_001005845.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC105091.3 (31239..42181)	None
genomic	AC108863.4 (101885..199217)	None
genomic	CH471080.2	EAW63283.1
		EAW63284.1
		EAW63285.1
mRNA	AF495383.1	AAM49575.1
mRNA	AK293257.1	BAG56789.1
mRNA	AV708278.1	None
mRNA	BC027996.1	None
mRNA	BC126406.1	AAI26407.1
mRNA	BC143923.1	AAI43924.1
mRNA	BC143924.1	None
mRNA	D14665.2	BAA03499.2
mRNA	U41766.1	AAC50403.1