Display Settings:

Format

Send to:

Choose Destination

TNFRSF25 tumor necrosis factor receptor superfamily, member 25 [ Homo sapiens (human) ]

Gene ID: 8718, updated on 19-Jul-2014
Official Symbol
TNFRSF25provided by HGNC
Official Full Name
tumor necrosis factor receptor superfamily, member 25provided by HGNC
Primary source
HGNC:11910
Locus tag
RP4-650H14.2
See related
Ensembl:ENSG00000215788; HPRD:04532; MIM:603366; Vega:OTTHUMG00000000831
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DR3; TR3; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; TNFRSF12
Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. [provided by RefSeq, Jul 2008]
See TNFRSF25 in Epigenomics, MapViewer
Location:
1p36.2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (6461151..6466195, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6520787..6527432, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 2 Neighboring gene microRNA 4252 Neighboring gene espin Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Neighboring gene nucleolar protein 9 Neighboring gene taste receptor, type 1, member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
tumor necrosis factor-activated receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process NAS
Non-traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
tumor necrosis factor-mediated signaling pathway TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytosol NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 25
Names
tumor necrosis factor receptor superfamily member 25
protein WSL-1
death receptor beta
apoptosis inducing receptor
apoptosis-inducing receptor AIR
apoptosis-mediating receptor DR3
apoptosis-mediating receptor TRAMP
death domain receptor 3 soluble form
lymphocyte-associated receptor of death
tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029910.1 

    Range
    5001..10045
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001039664.1NP_001034753.1  tumor necrosis factor receptor superfamily member 25 isoform 12 precursor

    See proteins identical to NP_001034753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks several 3' exons and has an alternate 3' end, when compared to variant 1. The resulting isoform (12) has a distinct and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AY358309, U83598
    UniProtKB/Swiss-Prot
    Q93038
    Conserved Domains (1) summary
    cd00185
    Location:35141
    Blast Score: 167
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  2. NM_003790.2NP_003781.1  tumor necrosis factor receptor superfamily member 25 isoform 2 precursor

    See proteins identical to NP_003781.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two coding segments, both of which result in a frameshift, when compared to variant 1. The resulting isoform (2) has a shorter and distinct internal region, as compared to isoform 1.
    Source sequence(s)
    BM666370, U74611
    Consensus CDS
    CCDS71.1
    UniProtKB/Swiss-Prot
    Q93038
    Related
    ENSP00000349341, OTTHUMP00000000922, ENST00000356876, OTTHUMT00000002259
    Conserved Domains (2) summary
    cd08815
    Location:334410
    Blast Score: 376
    Death_TNFRSF25_DR3; Death domain of Tumor Necrosis Factor Receptor superfamily 25
    cd00185
    Location:35141
    Blast Score: 214
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  3. NM_148965.1NP_683866.1  tumor necrosis factor receptor superfamily member 25 isoform 1 precursor

    See proteins identical to NP_683866.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF026070, AY358309, BC143886, BM666370
    Consensus CDS
    CCDS72.1
    UniProtKB/Swiss-Prot
    Q93038
    Related
    ENSP00000367013, OTTHUMP00000000925, ENST00000377782, OTTHUMT00000002262
    Conserved Domains (2) summary
    cd08815
    Location:343419
    Blast Score: 376
    Death_TNFRSF25_DR3; Death domain of Tumor Necrosis Factor Receptor superfamily 25
    cd00185
    Location:35141
    Blast Score: 222
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  4. NM_148966.1NP_683867.1  tumor necrosis factor receptor superfamily member 25 isoform 3 precursor

    See proteins identical to NP_683867.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two coding segments, both of which result in a frameshift, when compared to variant 1. The resulting isoform (3) contains a distinct and shorter internal segment, as compared to isoform 1.
    Source sequence(s)
    AY358309, BC143886, BM666370
    Consensus CDS
    CCDS73.1
    UniProtKB/Swiss-Prot
    Q93038
    Related
    ENSP00000337713, OTTHUMP00000220969, ENST00000351959, OTTHUMT00000366679
    Conserved Domains (2) summary
    cd08815
    Location:297373
    Blast Score: 376
    Death_TNFRSF25_DR3; Death domain of Tumor Necrosis Factor Receptor superfamily 25
    cd00185
    Location:35141
    Blast Score: 207
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  5. NM_148967.1NP_683868.1  tumor necrosis factor receptor superfamily member 25 isoform 4 precursor

    See proteins identical to NP_683868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks three coding segments, two of which result in a frameshift, when compared to variant 1. The resulting isoform (4) lacks an internal region, and contains a distinct and shorter internal segment, as compared to isoform 1.
    Source sequence(s)
    AY358309, BM666370, U94509
    Consensus CDS
    CCDS74.1
    UniProtKB/Swiss-Prot
    Q93038
    Conserved Domains (2) summary
    cd00185
    Location:35134
    Blast Score: 103
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:289365
    Blast Score: 374
    DD; Death Domain Superfamily of protein-protein interaction domains
  6. NM_148970.1NP_683871.1  tumor necrosis factor receptor superfamily member 25 isoform 7 precursor

    See proteins identical to NP_683871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame coding segment compared to variant 1. The resulting isoform (7) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AY358309, BM666370, U94508
    Consensus CDS
    CCDS75.1
    UniProtKB/Swiss-Prot
    Q93038
    Conserved Domains (1) summary
    cl14633
    Location:151227
    Blast Score: 361
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    6461151..6466195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    5668754..5673798
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    6509749..6514768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_148968.1: Suppressed sequence

    Description
    NM_148968.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_148969.1: Suppressed sequence

    Description
    NM_148969.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_148974.1: Suppressed sequence

    Description
    NM_148974.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.