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B3GALT4 beta-1,3-galactosyltransferase 4 [ Homo sapiens (human) ]

Gene ID: 8705, updated on 26-May-2016
Official Symbol
B3GALT4provided by HGNC
Official Full Name
beta-1,3-galactosyltransferase 4provided by HGNC
Primary source
HGNC:HGNC:919
See related
Ensembl:ENSG00000235863 HPRD:04370; MIM:603095; Vega:OTTHUMG00000031100
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GALT2; GALT4; BETA3GALT4
Summary
This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p21.3
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (33277140..33278825)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (33244917..33246602)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene HLA complex group 25 (non-protein coding) Neighboring gene VPS52, GARP complex subunit Neighboring gene ribosomal protein S18 Neighboring gene WD repeat domain 46 Neighboring gene microRNA 6873 Neighboring gene microRNA 6834 Neighboring gene prefoldin subunit 6

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
protein glycosylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
beta-1,3-galactosyltransferase 4
Names
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase 4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
UDP-galactose:beta-N-acetyl-galactosamine-beta-1,3-galactosyltransferase
b3Gal-T4
beta-1,3-GalTase 4
beta-3-galactosyltransferase 4
gal-T2
ganglioside galactosyltransferase
NP_003773.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003782.3NP_003773.1  beta-1,3-galactosyltransferase 4

    See identical proteins and their annotated locations for NP_003773.1

    Status: REVIEWED

    Source sequence(s)
    AB026730, AK075312, BU740293
    Consensus CDS
    CCDS34425.1
    UniProtKB/Swiss-Prot
    O96024
    UniProtKB/TrEMBL
    B3KQP5, Q5STJ7
    Related
    ENSP00000390784, OTTHUMP00000029128, ENST00000451237, OTTHUMT00000076162
    Conserved Domains (1) summary
    cl21608
    Location:85308
    Galactosyl_T; Galactosyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    33277140..33278825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_113891.3 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    4688621..4690306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_3

Genomic

  1. NT_167245.2 Reference GRCh38.p2 ALT_REF_LOCI_3

    Range
    4520654..4522339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_5

Genomic

  1. NT_167247.2 Reference GRCh38.p2 ALT_REF_LOCI_5

    Range
    4713106..4714791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_6

Genomic

  1. NT_167248.2 Reference GRCh38.p2 ALT_REF_LOCI_6

    Range
    4471560..4473245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    33246853..33248538
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)