PEA15 phosphoprotein enriched in astrocytes 15 [Homo sapiens] - Gene

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Summary

Official Symbol: PEA15provided by HGNC
Official Full Name: phosphoprotein enriched in astrocytes 15provided by HGNC
Primary source: HGNC:8822
Locus tag: RP11-536C5.8
See related: Ensembl:ENSG00000162734; HPRD:04579; MIM:603434; Vega:OTTHUMG00000031605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PED; MAT1; HMAT1; MAT1H; PEA-15; HUMMAT1H
Summary: This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. [provided by RefSeq, Sep 2011]

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Genomic context

Location :: 1q21.1

Sequence :: Chromosome: 1; NC_000001.10 (160175125..160185162)

See PEA15 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15)
Title: Vitamin D3 signalling in the brain enhances the function of phosphoprotein enriched in astrocytes--15 kD (PEA-15).
The protective effect of melatonin is likely mediated, in part, by inhibition of peroxynitrate-mediated nitrosative stress, which in turn relieves imbalance of mitochondrial HtrA2-PED signaling and endothelial cell death.
Title: Melatonin ameliorates ischemic-like injury-evoked nitrosative stress: Involvement of HtrA2/PED pathways in endothelial cells.
There was no significant difference in the frequency of three marker haplotype in the PEA15 gene in patient with schizophrenia.
Title: An association study on polymorphisms in the PEA15, ENTPD4, and GAS2L1 genes and schizophrenia.
The expressions of PED/PEA-15 and XIAP are elevated in hepatocellular carcinoma as compared with adjacent tissues and normal tissues.
Title: [Expression and clinical significance of anti-apoptotic factors PED/PEA-15 and XIAP in hepatocellular carcinoma].
PED/PEA-15 modulates Coxsackievirus-adenovirus receptor expression and adenoviral entry, by sequestering ERK1/2.
Title: PED/PEA-15 modulates coxsackievirus-adenovirus receptor expression and adenoviral infectivity via ERK-mediated signals in glioma cells.
provide molecular basis of the PED/PEA-15 functional interactions and detailed surface for the design and development of PED/PEA-15 binders
Title: NMR backbone dynamics studies of human PED/PEA-15 outline protein functional sites.
Data show that PED and Rac1 interact and that this interaction modulates cell migration/invasion processes in cancer cells through ERK1/2 pathway.
Title: PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells.
The results show that HNF-4alpha serves as a scaffold protein for histone deacetylase activities, thereby inhibiting liver expression of genes including PED.
Title: Hepatocyte nuclear factor (HNF)-4alpha-driven epigenetic silencing of the human PED gene.
PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner
Title: The PEA-15 protein regulates autophagy via activation of JNK.
Data show that PEA-15 prevents ERK1/2 localization to the plasma membrane, thereby inhibiting ERK1/2-dependent threonine phosphorylation of FRS2alpha to promote activation of the ERK1/2 MAP kinase pathway.
Title: Phosphoprotein enriched in astrocytes 15 kDa (PEA-15) reprograms growth factor signaling by inhibiting threonine phosphorylation of fibroblast receptor substrate 2alpha.

Submit: New GeneRIF Correction See all (34)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_003759.1	NP_005154.1	AKT1	BIND	PubMed	Akt interacts with PED.
NP_003759.1	NP_002737.1	MAPK3	BIND	PubMed	PEA-15 interacts with ERK 1.
NP_003759.1	NP_004577.1	RPS6KA3	BIND	PubMed	PEA-15 interacts with RSK2.
Q15121	O14678	ABCD4	HPRD	PubMed
Q15121	Chromosome 6 open reading frame 199	AKD1	HPRD	PubMed
Q15121	P31749	AKT1	HPRD	PubMed
Q15121	Q13555	CAMK2G	HPRD	PubMed
Q15121	Q14790	CASP8	HPRD	PubMed
Q15121	Q13158	FADD	HPRD	PubMed
Q15121	O43464	HTRA2	HPRD	PubMed
Q15121	P32004	L1CAM	HPRD	PubMed
Q15121	Q9Y383	LUC7L2	HPRD	PubMed
Q15121	P28482	MAPK1	HPRD	PubMed
Q15121	P27361	MAPK3	HPRD	PubMed
Q15121	Q9NVE7	PANK4	HPRD	PubMed
Q15121	Q13393	PLD1	HPRD	PubMed
Q15121	O14939	PLD2	HPRD	PubMed
Q15121	P17252	PRKCA	HPRD	PubMed
Q15121	P51812	RPS6KA3	HPRD	PubMed
BioGRID:114230	BioGRID:111784	ABCD4	BioGRID	PubMed	Two-hybrid
BioGRID:114230	BioGRID:107291	CASP8	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114230	BioGRID:114302	FADD	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114230	BioGRID:110094	L1CAM	BioGRID	PubMed	Two-hybrid
BioGRID:114230	BioGRID:119646	LUC7L2	BioGRID	PubMed	Two-hybrid
BioGRID:114230	BioGRID:111580	MAPK1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114230	BioGRID:111581	MAPK3	BioGRID	PubMed	Two-hybrid
BioGRID:114230	BioGRID:111196	PDPK1	BioGRID	PubMed	Two-hybrid
BioGRID:114230	BioGRID:111353	PLD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:114230	BioGRID:111354	PLD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:114230	BioGRID:112111	RPS6KA3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:114230	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
anti-apoptosis	IDA Inferred from Direct Assay more info	PubMed
carbohydrate transport	IEA Inferred from Electronic Annotation more info
negative regulation of glucose import	IDA Inferred from Direct Assay more info	PubMed
regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
response to morphine	IEA Inferred from Electronic Annotation more info
transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
microtubule associated complex	NAS Non-traceable Author Statement more info	PubMed

General protein information

Preferred Names: astrocytic phosphoprotein PEA-15

Names: astrocytic phosphoprotein PEA-15; homolog of mouse MAT-1 oncogene; phosphoprotein enriched in diabetes; Phosphoprotein enriched in astrocytes, 15kD; 15 kDa phosphoprotein enriched in astrocytes

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003768.3 → NP_003759.1 astrocytic phosphoprotein PEA-15

Status: VALIDATED

Source sequence(s)

AI948916, BC022554, DA532423

Consensus CDS

CCDS1199.1

UniProtKB/TrEMBL

B1AKZ4

UniProtKB/Swiss-Prot

Q15121

Related

ENSP00000353660, OTTHUMP00000029886, ENST00000360472, OTTHUMT00000077407

Conserved Domains (1) summary

cd08338
Location:2 – 85
Blast Score: 348

DED_PEA15; Death Effector Domain of Astrocyte phosphoprotein PEA-15

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

160175125..160185162

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

131531764..131541800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF153274.1	AAD56775.1
genomic	AL121987.34	CAI15277.1
		CAI15278.1
		CAI15279.1
genomic	AL121987.34	CAI15277.1
		CAI15278.1
		CAI15279.1
genomic	AL139011.20	None
genomic	CH471121.2	EAW52733.1
		EAW52734.1
		EAW52735.1
mRNA	AI948916.1	None
mRNA	AK095879.1	BAG53155.1
mRNA	AK311762.1	BAG34705.1
mRNA	BC002426.2	AAH02426.1
mRNA	BC010469.1	AAH10469.1
mRNA	BC022554.1	AAH22554.1
mRNA	BT007252.1	AAP35916.1
mRNA	CR541733.1	CAG46533.1
mRNA	DA532423.1	None
mRNA	L37385.1	AAA98120.1
mRNA	X86809.1	CAA60499.1
mRNA	Y13736.1	CAA74076.1
other-genetic	DQ891821.2	ABM82747.1
other-genetic	DQ891824.2	ABM82750.1
other-genetic	DQ895008.2	ABM85934.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q14801	GenPept	UniProtKB/TrEMBL:Q14801
Q15121.2	GenPept	UniProtKB/Swiss-Prot:Q15121
Q6FHL9	GenPept	UniProtKB/TrEMBL:Q6FHL9
Q96FS5	GenPept	UniProtKB/TrEMBL:Q96FS5