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    CBLB Cbl proto-oncogene, E3 ubiquitin protein ligase B [ Homo sapiens ]

    Gene ID: 868, updated on 19-May-2012
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    Summary

    Official Symbol
    CBLBprovided by HGNC
    Official Full Name
    Cbl proto-oncogene, E3 ubiquitin protein ligase Bprovided by HGNC
    Primary source
    HGNC:1542
    Locus tag
    Nbla00127
    See related
    Ensembl:ENSG00000114423; HPRD:05136; MIM:604491; Vega:OTTHUMG00000150654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Cbl-b; RNF56; Nbla00127; FLJ36865; FLJ41152; DKFZp779A0729; DKFZp779F1443; DKFZp686J10223
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    Genomic context

    Location :
    3q13.11
    Sequence :
    Chromosome: 3; NC_000003.11 (105377109..105587887, complement)
    See CBLB in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene ezrin pseudogene Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene FCF1 small subunit (SSU) processome component homolog (S. cerevisiae) pseudogene Neighboring gene transfer RNA glutamine 42 (anticodon UUG) pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b. Kobashigawa Y, et al. Proc Natl Acad Sci U S A, 2011 Dec 20. PMID 22158902.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. Th3 immune responses in the progression of leprosy via molecular cross-talks of TGF-β, CTLA-4 and Cbl-b. Kumar S, et al. Clin Immunol, 2011 Nov. PMID 21807564.
    4. c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway. Oshikawa G, et al. J Biol Chem, 2011 Sep 2. PMID 21768087.
    5. [Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC]. Jiao X, et al. Zhongguo Fei Ai Za Zhi, 2011 Jun. PMID 21645455.

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
      Title: Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b.
    2. Over expression of TGF-beta and CTLA-4 leads to T cell hyporesponsiveness, a major hallmark of leprosy, by increasing the expression of Cbl-b.
      Title: Th3 immune responses in the progression of leprosy via molecular cross-talks of TGF-β, CTLA-4 and Cbl-b.
    3. Overexpressions of c-Cbl, Cbl-b, and EGFR are closely related to the invasion and progression of gastric carcinoma.
      Title: [Expression of c-Cbl, Cbl-b, and epidermal growth factor receptor in gastric carcinoma and their clinical significance].
    4. c-Cbl as well as Cbl-b may play important roles in Hsp90 inhibitor-induced degradation of Flt3-ITD through the ubiquitin proteasome system
      Title: c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.
    5. the expression and clinical relevance of c-Cbl, Cbl-b and EGFR in non-small cell lung cancer
      Title: [Expressions of c-Cbl, Cbl-b and EGFR and its role of prognosis in NSCLC].
    6. data suggest that Cbl-b may contribute to the deregulated activation of T lymphocytes observed in systemic lupus erythematosus (SLE); a significant association between the 2126(A/G) SNP and SLE was detected
      Title: Expression and function of Cbl-b in T cells from patients with systemic lupus erythematosus, and detection of the 2126 A/G Cblb gene polymorphism in the Mexican mestizo population.
    7. CBLB mutation is asssociated with chronic myelogenous leukemia.
      Title: CBL, CBLB, TET2, ASXL1, and IDH1/2 mutations and additional chromosomal aberrations constitute molecular events in chronic myelogenous leukemia.
    8. Deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a in T cells were found to be associated with cholesterol-dependent-dismantling of HLA-DR rafts in macrophages in leprosy progression.
      Title: Disruption of HLA-DR raft, deregulations of Lck-ZAP-70-Cbl-b cross-talk and miR181a towards T cell hyporesponsiveness in leprosy.
    9. These data provide further evidence of the association of MS disease with variation within CBLB.
      Title: Association of the CBLB gene with multiple sclerosis: new evidence from a replication study in an Italian population.
    10. Interplay between transgenic Cblb-dependent T cell anergy and other mechanisms prevents organ-specific islet-cell autoimmunity.
      Title: Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes.
    Submit: New GeneRIF Correction See all (30)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_733762.2 NP_005833.1 SPRY2    BIND  PubMed SPRY2 interacts with Cbl-b. 
    Q13191 Q14155 ARHGEF7    HPRD  PubMed  
    Q13191 Q8WV28 BLNK    HPRD  PubMed  
    Q13191 P46109 CRKL    HPRD  PubMed  
    Q13191 Q16526 CRY1    HPRD  PubMed  
    Q13191 P00533 EGFR    HPRD  PubMed  
    Q13191 P36888 FLT3    HPRD  PubMed  
    Q13191 O15117 FYB    HPRD  PubMed  
    Q13191 P06241 FYN    HPRD  PubMed  
    Q13191 Q9H8Y8 GORASP2    HPRD  PubMed  
    Q13191 P62993 GRB2    HPRD  PubMed  
    Q13191 P10721 KIT    HPRD  PubMed  
    Q13191 P16333 NCK1    HPRD  PubMed  
    Q13191 O43639 NCK2    HPRD  PubMed  
    Q13191 P46934 NEDD4    HPRD  PubMed  
    Q13191 P27986 PIK3R1    HPRD  PubMed  
    Q13191 P16885 PLCG2    HPRD  PubMed  
    Q13191 P07949 RET    HPRD  PubMed  
    Q13191 Q9Y3C5 RNF11    HPRD  PubMed  
    Q13191 Q96B97 SH3KBP1    HPRD  PubMed  
    Q13191 P29353 SHC1    HPRD  PubMed  
    Q13191 O60504 SORBS3    HPRD  PubMed  
    Q13191 O43597 SPRY2    HPRD  PubMed  
    Q13191 P43405 SYK    HPRD  PubMed  
    Q13191 Q9Y6Q6 TNFRSF11A    HPRD  PubMed  
    Q13191 P15498 VAV1    HPRD  PubMed  
    Q13191 P43403 ZAP70    HPRD  PubMed  
    BioGRID:107316 BioGRID:107160 BTK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:124073 CARD11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:107789 CRKL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:107797 CRY1    BioGRID  PubMed Two-hybrid 
    BioGRID:107316 BioGRID:108276 EGFR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:107316 BioGRID:117479 GORASP2    BioGRID  PubMed Two-hybrid 
    BioGRID:107316 BioGRID:109142 GRB2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:107316 BioGRID:109874 IRS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:110015 KIT    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:114020 NCK2    BioGRID  PubMed Two-hybrid 
    BioGRID:107316 BioGRID:110811 NEDD4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:107316 BioGRID:111313 PIK3R1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:111352 PLCG2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:119029 SH3KBP1    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:107316 BioGRID:112361 SHC1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:115475 SORBS3    BioGRID  PubMed Two-hybrid 
    BioGRID:107316 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:113164 UBC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:107316 BioGRID:113252 VAV1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:107316 BioGRID:113367 ZAP70    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystem (from REACTOME)
      Antigen Activates B Cell Receptor Leading to Generation of Second Messengers, organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, Fu et al. 1975, Kunkel e...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
    • Bacterial invasion of epithelial cells, organism-specific biosystem (from KEGG)
      Bacterial invasion of epithelial cells, organism-specific biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • Bacterial invasion of epithelial cells, conserved biosystem (from KEGG)
      Bacterial invasion of epithelial cells, conserved biosystemMany pathogenic bacteria can invade phagocytic and non-phagocytic cells and colonize them intracellularly, then become disseminated to other cells. Invasive bacteria induce their own uptake by non-ph...
    • CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
      CD40/CD40L signaling, organism-specific biosystem
      CD40/CD40L signaling
    • Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem (from Pathway Interaction Database)
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem
      Calcineurin-regulated NFAT-dependent transcription in lymphocytes
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem (from Pathway Interaction Database)
      Fc-epsilon receptor I signaling in mast cells, organism-specific biosystem
      Fc-epsilon receptor I signaling in mast cells
    • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 belongs to a family of cytokines, which includes IL-2, IL-4, IL-9, IL-15 and IL-21. It signals through a receptor complex consisting of IL-7 receptor alpha chain (IL7RA) and a common ga...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Insulin Signaling, organism-specific biosystem (from WikiPathways)
      Insulin Signaling, organism-specific biosystem
      Insulin Signaling
    • Insulin signaling pathway, organism-specific biosystem (from KEGG)
      Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Insulin signaling pathway, conserved biosystem (from KEGG)
      Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
    • Internalization of ErbB1, organism-specific biosystem (from Pathway Interaction Database)
      Internalization of ErbB1, organism-specific biosystem
      Internalization of ErbB1
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Measles, organism-specific biosystem (from KEGG)
      Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Measles, conserved biosystem (from KEGG)
      Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • T cell receptor signaling pathway, organism-specific biosystem (from KEGG)
      T cell receptor signaling pathway, organism-specific biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • T cell receptor signaling pathway, conserved biosystem (from KEGG)
      T cell receptor signaling pathway, conserved biosystemActivation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. En...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphotyrosine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transducer activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NLS-bearing substrate import into nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 
    T cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of alpha-beta T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of T cell anergy IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to gravity IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane raft IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    E3 ubiquitin-protein ligase CBL-B
    RING finger protein 56
    SH3-binding protein CBL-B
    signal transduction protein CBL-B
    casitas B-lineage lymphoma proto-oncogene b
    Cas-Br-M (murine) ectropic retroviral transforming sequence b
    Cas-Br-M (murine) ecotropic retroviral transforming sequence b
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_170662.3 → NP_733762.2  E3 ubiquitin-protein ligase CBL-B

      Status: VALIDATED

      Source sequence(s)
      AA251219, AK094184, AK130668, BC032851, BC065915, BQ188745, R78694, U26710
      Consensus CDS
      CCDS2948.1
      UniProtKB/TrEMBL
      A8K9S7
      UniProtKB/TrEMBL
      B3KSS7
      UniProtKB/Swiss-Prot
      Q13191
      Related
      ENSP00000264122, OTTHUMP00000198145, ENST00000264122, OTTHUMT00000319417
      Conserved Domains (5) summary
      cd00162
      Location:373 – 415
      Blast Score: 126
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd00194
      Location:933 – 969
      Blast Score: 101
      UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
      pfam02262
      Location:42 – 168
      Blast Score: 565
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      cd09920
      Location:248 – 344
      Blast Score: 527
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      pfam02761
      Location:171 – 254
      Blast Score: 445
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      105377109..105587887, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      102751829..102962841, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC016138.8 None
    genomic AC112485.4 (2005..26320) None
    genomic AC126185.2 (1999..81760) None
    genomic CH471052.2 EAW79751.1
      EAW79752.1
      EAW79753.1
      EAW79754.1
    mRNA AA251219.1 None
    mRNA AB075490.1 BAE45748.1
    mRNA AK094184.1 BAG52839.1
    mRNA AK123147.1 BAG53874.1
    mRNA AK130668.1 None
    mRNA AK292792.1 BAF85481.1
    mRNA AK302533.1 BAG63805.1
    mRNA AK302892.1 BAG64066.1
    mRNA AK316276.1 BAH14647.1
    mRNA BC032851.2 AAH32851.1
    mRNA BC065915.1 None
    mRNA BQ188745.1 None
    mRNA BX537484.1 CAH56175.1
    mRNA BX649066.1 None
    mRNA CR749655.1 CAH18449.1
    mRNA DQ349203.1 ABC86700.1
    mRNA DQ349204.1 ABC86701.1
    mRNA R78694.1 None
    mRNA U26710.1 AAB09291.1
    mRNA U26711.1 AAB09292.1
    mRNA U26712.1 AAB09293.1
    other-genetic DQ894452.2 ABM85378.1
    other-genetic EU176266.1 ABW03717.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13191.2 GenPept UniProtKB/Swiss-Prot:Q13191
    Q68CY2 GenPept UniProtKB/TrEMBL:Q68CY2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

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