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CBLB Cbl proto-oncogene B [ Homo sapiens (human) ]

Gene ID: 868, updated on 29-May-2016
Official Symbol
CBLBprovided by HGNC
Official Full Name
Cbl proto-oncogene Bprovided by HGNC
Primary source
HGNC:HGNC:1542
See related
Ensembl:ENSG00000114423 HPRD:05136; MIM:604491; Vega:OTTHUMG00000150654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Cbl-b; RNF56; Nbla00127
Orthologs
Location:
3q13.11
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (105655461..105869552, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (105374306..105589354, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374023 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene uncharacterized LOC105374024 Neighboring gene uncharacterized LOC105374025

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of Cbl proto-oncogene B, E3 ubiquitin protein ligase (CBLB) in human B cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36865, FLJ41152, DKFZp779A0729, DKFZp779F1443, DKFZp686J10223

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
ligase activity IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
NLS-bearing protein import into nucleus TAS
Traceable Author Statement
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
response to gravity IEA
Inferred from Electronic Annotation
more info
 
response to hormone IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane raft IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
E3 ubiquitin-protein ligase CBL-B
Names
Cas-Br-M (murine) ecotropic retroviral transforming sequence b
Cbl proto-oncogene B, E3 ubiquitin protein ligase
Cbl proto-oncogene, E3 ubiquitin protein ligase B
RING finger protein 56
SH3-binding protein CBL-B
casitas B-lineage lymphoma proto-oncogene b
signal transduction protein CBL-B

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321786.1NP_001308715.1  E3 ubiquitin-protein ligase CBL-B isoform a

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:70196
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:959999
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  2. NM_001321788.1NP_001308717.1  E3 ubiquitin-protein ligase CBL-B isoform b

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  3. NM_001321789.1NP_001308718.1  E3 ubiquitin-protein ligase CBL-B isoform c

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:70196
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:276372
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:199282
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:401443
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:910950
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  4. NM_001321790.1NP_001308719.1  E3 ubiquitin-protein ligase CBL-B isoform d

    Status: VALIDATED

    Source sequence(s)
    AC016138, AI221219, AK302533, AK316276
    Conserved Domains (5) summary
    pfam02262
    Location:64190
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:270366
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:193276
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:395437
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:909949
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  5. NM_001321791.1NP_001308720.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: VALIDATED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  6. NM_001321793.1NP_001308722.1  E3 ubiquitin-protein ligase CBL-B isoform e

    Status: VALIDATED

    Description
    Transcript Variant: Variants 6 and 7 encode the same isoform (e).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  7. NM_001321794.1NP_001308723.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  8. NM_001321795.1NP_001308724.1  E3 ubiquitin-protein ligase CBL-B isoform f

    Status: VALIDATED

    Description
    Transcript Variant: Variants 8 and 9 encode the same isoform (f), which is the same length as isoform g but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  9. NM_001321796.1NP_001308725.1  E3 ubiquitin-protein ligase CBL-B isoform g

    Status: VALIDATED

    Description
    Transcript Variant: Isoform g is the same length as isoform f but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    pfam02262
    Location:42140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:882922
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  10. NM_001321797.1NP_001308726.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  11. NM_001321798.1NP_001308727.1  E3 ubiquitin-protein ligase CBL-B isoform h

    Status: VALIDATED

    Description
    Transcript Variant: Variants 11 and 12 encode the same isoform (h), which is the same length as isoform i but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  12. NM_001321799.1NP_001308728.1  E3 ubiquitin-protein ligase CBL-B isoform i

    Status: VALIDATED

    Description
    Transcript Variant: Isoform i is the same length as isoform h but differs in the amino acid sequence.
    Source sequence(s)
    AC016138, AC112485
    Conserved Domains (5) summary
    pfam02262
    Location:42140
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:199295
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:123205
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:324366
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:838878
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  13. NM_001321806.1NP_001308735.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: VALIDATED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  14. NM_001321807.1NP_001308736.1  E3 ubiquitin-protein ligase CBL-B isoform j

    Status: VALIDATED

    Description
    Transcript Variant: Variants 14 and 15 encode the same isoform (j).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:671711
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  15. NM_001321808.1NP_001308737.1  E3 ubiquitin-protein ligase CBL-B isoform k

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:627667
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  16. NM_001321811.1NP_001308740.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: VALIDATED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  17. NM_001321813.1NP_001308742.1  E3 ubiquitin-protein ligase CBL-B isoform l

    Status: VALIDATED

    Description
    Transcript Variant: Variants 17 and 18 encode the same isoform (l).
    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:622662
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  18. NM_001321816.1NP_001308745.1  E3 ubiquitin-protein ligase CBL-B isoform m

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (3) summary
    cd09920
    Location:184
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:113155
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:578618
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  19. NM_001321820.1NP_001308749.1  E3 ubiquitin-protein ligase CBL-B isoform n

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:491531
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  20. NM_001321822.1NP_001308751.1  E3 ubiquitin-protein ligase CBL-B isoform o

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
    Conserved Domains (1) summary
    cd14392
    Location:488528
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  21. NM_170662.4NP_733762.2  E3 ubiquitin-protein ligase CBL-B isoform b

    See identical proteins and their annotated locations for NP_733762.2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 2 and 3 encode the same isoform (b).
    Source sequence(s)
    AC016138, AI221219, AK094184, BC032851, BC065915, U26710
    Consensus CDS
    CCDS2948.1
    UniProtKB/Swiss-Prot
    Q13191
    UniProtKB/TrEMBL
    B3KSS7
    Related
    ENSP00000264122, OTTHUMP00000198145, ENST00000264122, OTTHUMT00000319417
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins

RNA

  1. NR_135806.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  2. NR_135807.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  3. NR_135808.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  4. NR_135809.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  5. NR_135810.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  6. NR_135811.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185
  7. NR_135812.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016138, AC112485, AC126185

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    105655461..105869552 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513257.1XP_011511559.1  

    See identical proteins and their annotated locations for XP_011511559.1

    UniProtKB/Swiss-Prot
    Q13191
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  2. XM_005247853.2XP_005247910.1  

    UniProtKB/Swiss-Prot
    Q13191
    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:931971
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  3. XM_011513258.1XP_011511560.1  

    Conserved Domains (5) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14392
    Location:887927
    UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
  4. XM_011513259.1XP_011511561.1  

    Related
    ENSP00000384938, OTTHUMP00000198147, ENST00000405772, OTTHUMT00000319419
    Conserved Domains (4) summary
    pfam02262
    Location:42168
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    pfam02761
    Location:171254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    cd00162
    Location:373415
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RNA

  1. XR_924205.1 RNA Sequence

  2. XR_924204.1 RNA Sequence

  3. XR_924206.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    105340227..105551366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)