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STX16 syntaxin 16 [ Homo sapiens (human) ]

Gene ID: 8675, updated on 12-Apr-2014
Official Symbol
STX16provided by HGNC
Official Full Name
syntaxin 16provided by HGNC
Primary source
HGNC:11431
Locus tag
RP11-261P9.3
See related
Ensembl:ENSG00000124222; HPRD:04718; MIM:603666; Vega:OTTHUMG00000033084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SYN16
Summary
This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]
Location :
20q13.32
Sequence :
Chromosome: 20; NC_000020.11 (58651253..58679526)
See STX16 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene adenomatosis polyposis coli down-regulated 1-like Neighboring gene APCDD1L antisense RNA 1 (head to head) Neighboring gene STX16-NPEPL1 readthrough (NMD candidate) Neighboring gene aminopeptidase-like 1 Neighboring gene uncharacterized LOC100652930

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Pseudohypoparathyroidism type 1B
MedGen: C1864100 OMIM: 603233 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough STX16-NPEPL1

Readthrough gene: STX16-NPEPL1, Included gene: NPEPL1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNAP receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
intra-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
SNARE complex IDA
Inferred from Direct Assay
more info
PubMed 
SNARE complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleolus IDA
Inferred from Direct Assay
more info
 
Preferred Names
syntaxin-16
Names
syntaxin-16

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011831.1 RefSeqGene

    Range
    4982..33255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001433.2NP_001001433.1  syntaxin-16 isoform a

    See proteins identical to NP_001001433.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also referred to as isoform B).
    Source sequence(s)
    AA256337, AK026970, AL139349, BU844980, CA427122, DC424825
    Consensus CDS
    CCDS13468.1
    UniProtKB/Swiss-Prot
    O14662
    Related
    ENSP00000360183, OTTHUMP00000031790, ENST00000371141, OTTHUMT00000080517
    Conserved Domains (2) summary
    cd00193
    Location:233292
    Blast Score: 166
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam00804
    Location:79173
    Blast Score: 140
    Syntaxin; Syntaxin
  2. NM_001134772.2NP_001128244.1  syntaxin-16 isoform c

    See proteins identical to NP_001128244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter isoform (c), compared to isoform a.
    Source sequence(s)
    AA256337, AK026974, AL139349, BC073876, BU844980, CA427122, DC424825
    Consensus CDS
    CCDS46619.1
    UniProtKB/Swiss-Prot
    O14662
    Related
    ENSP00000350723, OTTHUMP00000174365, ENST00000358029, OTTHUMT00000080525
    Conserved Domains (2) summary
    cd00193
    Location:229288
    Blast Score: 168
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam00804
    Location:75169
    Blast Score: 141
    Syntaxin; Syntaxin
  3. NM_001134773.2NP_001128245.1  syntaxin-16 isoform d

    See proteins identical to NP_001128245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in a shorter isoform (d), compared to isoform a.
    Source sequence(s)
    AA256337, AK026974, AL139349, BC019042, BU844520, BU844980, CA427122, DC424825
    Consensus CDS
    CCDS46620.1
    UniProtKB/Swiss-Prot
    O14662
    Related
    ENSP00000348229, OTTHUMP00000031792, ENST00000355957, OTTHUMT00000080519
    Conserved Domains (2) summary
    cd00193
    Location:216275
    Blast Score: 164
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam00804
    Location:62156
    Blast Score: 139
    Syntaxin; Syntaxin
  4. NM_001204868.1NP_001191797.1  syntaxin-16 isoform e

    See proteins identical to NP_001191797.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (e) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA256337, AK026974, AK316547, AL050327, AL139349, BC019042, BX396221, CA427122
    Consensus CDS
    CCDS56199.1
    UniProtKB/TrEMBL
    B4DJX9
    UniProtKB/Swiss-Prot
    O14662
    Related
    ENSP00000352634, OTTHUMP00000174361, ENST00000359617, OTTHUMT00000267913
    Conserved Domains (2) summary
    cd00193
    Location:180239
    Blast Score: 168
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam00804
    Location:26120
    Blast Score: 143
    Syntaxin; Syntaxin
  5. NM_003763.5NP_003754.2  syntaxin-16 isoform b

    See proteins identical to NP_003754.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter isoform (b, also referred to as isoform A), compared to isoform a.
    Source sequence(s)
    AA256337, AK026974, AL139349, BC019042, BU844980, CA427122, DC424825
    Consensus CDS
    CCDS13469.1
    UniProtKB/Swiss-Prot
    O14662
    Related
    ENSP00000360173, OTTHUMP00000031789, ENST00000371132, OTTHUMT00000080516
    Conserved Domains (2) summary
    cd00193
    Location:212271
    Blast Score: 165
    t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...
    pfam00804
    Location:58152
    Blast Score: 139
    Syntaxin; Syntaxin

RNA

  1. NR_037941.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' region and lacks an exon in the central region, compared to variant 1. This variant is represented as non-coding because the use of the supported start codon, as used in variant 1, would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA256337, AF008937, AK026974, AL139349, BC073876, BU844980, CA427122, DC424825
  2. NR_037942.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has alternate exon structure in the 5' region and lacks an exon in the central region, compared to variant 1. This variant is represented as non-coding because it lacks the supported start codon, as found in variant 1, and the use of the next available in-frame start codon would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA256337, AK026974, AK316547, AL139349, BC019042, CA427122
  3. NR_037943.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) has alternate exon structure in the 5' region and lacks an exon in the central region, compared to variant 1. This variant is represented as non-coding because it lacks the supported start codon, as found in variant 1, and the use of the next available in-frame start codon would render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AA256337, AK026974, AK316547, AL139349, BC019042, BQ229292, CA427122

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38 Primary Assembly

    Range
    58651253..58679526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    54010737..54039011
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    57127816..57156091
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001001434.1: Suppressed sequence

    Description
    NM_001001434.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

Supplemental Content

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