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EIF3C eukaryotic translation initiation factor 3 subunit C [ Homo sapiens (human) ]

Gene ID: 8663, updated on 8-May-2016
Official Symbol
EIF3Cprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
Primary source
HGNC:HGNC:3279
See related
Ensembl:ENSG00000184110 HPRD:04889; MIM:603916; Vega:OTTHUMG00000099443
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3CL; EIF3S8; eIF3-p110
Orthologs
Location:
16p11.2
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (28688558..28735730)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28699879..28747051)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 1A member 1 Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene cell division cycle 37 pseudogene 1 Neighboring gene microRNA 6862-2 Neighboring gene uncharacterized LOC105379464 Neighboring gene nuclear pore complex interacting protein family member B9 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene ribosomal protein S15a pseudogene 33

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Common variants at five new loci associated with early-onset inflammatory bowel disease.
NHGRI GWA Catalog
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

  • Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystem (from REACTOME)
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific biosystemThe cap-binding complex is constituted by the initiation factors eIF4A, eIF4G and eIF4E. First, eIF4E must be released from the inactive eIF4E:4E-BP complex. Then eIF4A interacts with eIF4G, and eIF...
  • Cap-dependent Translation Initiation, organism-specific biosystem (from REACTOME)
    Cap-dependent Translation Initiation, organism-specific biosystemTranslation initiation is a complex process in which the Met-tRNAi initiator, 40S, and 60S ribosomal subunits are assembled by eukaryotic initiation factors (eIFs) into an 80S ribosome at the start c...
  • Eukaryotic Translation Initiation, organism-specific biosystem (from REACTOME)
    Eukaryotic Translation Initiation, organism-specific biosystemInitiation of translation in the majority of eukaryotic cellular mRNAs depends on the 5'-cap (m7GpppN) and involves ribosomal scanning of the 5' untranslated region (5'-UTR) for an initiating AUG sta...
  • Formation of a pool of free 40S subunits, organism-specific biosystem (from REACTOME)
    Formation of a pool of free 40S subunits, organism-specific biosystemThe 80S ribosome dissociates into free 40S (small) and 60S (large) ribosomal subunits. Each ribosomal subunit is constituted by several individual ribosomal proteins and rRNA.
  • Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystem (from REACTOME)
    Formation of the ternary complex, and subsequently, the 43S complex, organism-specific biosystemBinding of the methionyl-tRNA initiator to the active eIF2:GTP complex results in the formation of the ternary complex. Subsequently, this Met-tRNAi:eIF2:GTP (ternary) complex binds to the complex fo...
  • GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystem (from REACTOME)
    GTP hydrolysis and joining of the 60S ribosomal subunit, organism-specific biosystemHydrolysis of eIF2-GTP occurs after the Met-tRNAi has recognized the AUG. This reaction is catalyzed by eIF5 (or eIF5B) and is thought to cause dissociation of all other initiation factors and allow ...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystem (from REACTOME)
    L13a-mediated translational silencing of Ceruloplasmin expression, organism-specific biosystemWhile circularization of mRNA during translation initiation is thought to contribute to an increase in the efficiency of translation, it also appears to provide a mechanism for translational silencin...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • Ribosomal scanning and start codon recognition, organism-specific biosystem (from REACTOME)
    Ribosomal scanning and start codon recognition, organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the initiation codon and forms a 48S complex, in which the initiation codon is base paired to the anticodon o...
  • Translation, organism-specific biosystem (from REACTOME)
    Translation, organism-specific biosystemProtein synthesis is accomplished through the process of translation of an mRNA sequence into a polypeptide chain. This process can be divided into three distinct stages: initiation, elongation and ...
  • Translation Factors, organism-specific biosystem (from WikiPathways)
    Translation Factors, organism-specific biosystemProtein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, ...
  • Translation initiation complex formation, organism-specific biosystem (from REACTOME)
    Translation initiation complex formation, organism-specific biosystemThe translation initiation complex forms when the 43S complex binds the mRNA that is associated with eIF4F, eIF4B and eIF4H. eIF4G in the eIF4F complex can directly contact eIF3 in the 43S complex. e...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
formation of translation preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
regulation of translational initiation IEA
Inferred from Electronic Annotation
more info
 
translational initiation IC
Inferred by Curator
more info
PubMed 
translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
translational initiation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 3 subunit C
Names
cell migration-inducing protein 17
eIF3 p110
eukaryotic translation initiation factor 3 subunit 8
eukaryotic translation initiation factor 3, subunit 8 (110kD)
eukaryotic translation initiation factor 3, subunit 8, 110kDa
eukaryotic translation initiation factor 3, subunit C

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037808.2NP_001032897.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001032897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AL045958, BC001571, BC071705, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000378953, ENST00000395587
    Conserved Domains (2) summary
    smart00753
    Location:778866
    PAM; PCI/PINT associated module
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  2. NM_001199142.1NP_001186071.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001186071.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AA679705, AK292155
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000457963, OTTHUMP00000254107, ENST00000566501, OTTHUMT00000430990
    Conserved Domains (2) summary
    smart00753
    Location:778866
    PAM; PCI/PINT associated module
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  3. NM_001267574.2NP_001254503.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_001254503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, AK000739, AL045958, BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000457418, OTTHUMP00000254110, ENST00000566866, OTTHUMT00000431000
    Conserved Domains (2) summary
    smart00753
    Location:778866
    PAM; PCI/PINT associated module
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  4. NM_001286478.1NP_001273407.1  eukaryotic translation initiation factor 3 subunit C isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC145285, AK303790, BC001571, DC341554
    Consensus CDS
    CCDS66993.1
    UniProtKB/Swiss-Prot
    Q99613
    Related
    ENSP00000456416, OTTHUMP00000254109, ENST00000564243, OTTHUMT00000430997
    Conserved Domains (2) summary
    smart00753
    Location:768856
    PAM; PCI/PINT associated module
    pfam05470
    Location:29695
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus
  5. NM_003752.4NP_003743.1  eukaryotic translation initiation factor 3 subunit C isoform a

    See identical proteins and their annotated locations for NP_003743.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
    Source sequence(s)
    AC145285, BC001571, DC341554
    Consensus CDS
    CCDS10638.1
    UniProtKB/Swiss-Prot
    Q99613
    UniProtKB/TrEMBL
    A0A024QYU9
    Related
    ENSP00000332604, OTTHUMP00000125295, ENST00000331666, OTTHUMT00000216908
    Conserved Domains (2) summary
    smart00753
    Location:778866
    PAM; PCI/PINT associated module
    pfam05470
    Location:29705
    eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    28688558..28735730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    29706766..29758789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)