AOC3 amine oxidase, copper containing 3 (vascular adhesion protein 1) [Homo sapiens] - Gene

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Summary

Official Symbol: AOC3provided by HGNC
Official Full Name: amine oxidase, copper containing 3 (vascular adhesion protein 1)provided by HGNC
Primary source: HGNC:550
See related: Ensembl:ENSG00000131471; HPRD:04770; MIM:603735
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HPAO; SSAO; VAP1; VAP-1
Summary: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb downstream. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17q21

Sequence :: Chromosome: 17; NC_000017.10 (41003201..41010141)

See AOC3 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

using an endothelial cell model, a description for the first time the involvement of the leucocyte-adhesion activity of SSAO/VAP-1 in the Abeta (amyloid beta-peptide)-mediated pro-inflammatory effect
Title: Vascular cell lines expressing SSAO/VAP-1: a new experimental tool to study its involvement in vascular diseases.
The Siglec-9 peptide binding to the enzymatic groove of VAP-1 can be used for imaging conditions, such as inflammation and cancer.
Title: Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer.
These remarks suggest that MAO-A and SSAO may play an important role in vascular tissue as well as in the vascular pathophysiology of type 2 diabetes.
Title: Monoamine oxidase and semicarbazide-sensitive amine oxidase kinetic analysis in mesenteric arteries of patients with type 2 diabetes.
Met211 and Leu469 were shown to be key residues for substrate specificity.
Title: Identification of two imidazole binding sites and key residues for substrate specificity in human primary amine oxidase AOC3.
Serum VAP-1 can predict 10-year all-cause mortality, cardiovascular mortality, and cancer mortality independently in type 2 diabetic subjects.
Title: Serum vascular adhesion protein-1 predicts 10-year cardiovascular and cancer mortality in individuals with type 2 diabetes.
The structure of VAP-1 was refined to a resolution of 2.9A.
Title: A new crystal form of human vascular adhesion protein 1.
A novel combination of surface molecules, including VAP-1 and CX(3)CL1 promotes the recruitment of CD16(+) monocytes to the liver, allowing them to localize at sites of chronic inflammation and fibrosis.
Title: CX(3)CR1 and vascular adhesion protein-1-dependent recruitment of CD16(+) monocytes across human liver sinusoidal endothelium.
The SSAO activity in the serum of patients with type 2 diabetes is higher when compared with control group and may be a useful marker for diabetes.
Title: Changes in the activities of semicarbazide-sensitive amine oxidase in inferior mesenteric artery segments and in serum of patients with type 2 diabetes.
immunohistochemistry reveals constitutive expression of VAP-1 in human ocular tissues.
Title: Localization of vascular adhesion protein-1 (VAP-1) in the human eye.
Inflammation of the dental pulp was accompanied by a significant decrease in MAO labeling, MAO B (but not MAO A) activity and the increase in SSAO activity.
Title: Monoamine oxidase and semicarbazide sensitive amine oxidase activities in normal and inflamed human dental pulp.

Submit: New GeneRIF Correction See all (39)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q16853	P15498	VAV1		HPRD	PubMed

Function	Evidence Code	Pubs
aliphatic-amine oxidase activity	IEA Inferred from Electronic Annotation more info
aminoacetone:oxygen oxidoreductase(deaminating) activity	IEA Inferred from Electronic Annotation more info
calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
cation channel activity	IDA Inferred from Direct Assay more info	PubMed
copper ion binding	IDA Inferred from Direct Assay more info	PubMed
copper ion binding	TAS Traceable Author Statement more info	PubMed
oxidoreductase activity	IEA Inferred from Electronic Annotation more info
phenethylamine:oxygen oxidoreductase (deaminating) activity	IEA Inferred from Electronic Annotation more info
primary amine oxidase activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	TAS Traceable Author Statement more info	PubMed
quinone binding	IDA Inferred from Direct Assay more info	PubMed
tryptamine:oxygen oxidoreductase (deaminating) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
amine metabolic process	IDA Inferred from Direct Assay more info	PubMed
amine metabolic process	TAS Traceable Author Statement more info	PubMed
cell adhesion	IDA Inferred from Direct Assay more info	PubMed
inflammatory response	TAS Traceable Author Statement more info	PubMed
response to antibiotic	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
integral to membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: membrane primary amine oxidase

Names: membrane primary amine oxidase; copper amine oxidase; vascular adhesion protein 1; semicarbazide-sensitive amine oxidase

NP_003725.1

EC 1.4.3.21

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003734.2 → NP_003725.1 membrane primary amine oxidase

Status: REVIEWED

Source sequence(s)

U39447

Consensus CDS

CCDS11444.1

UniProtKB/Swiss-Prot

Q16853

Related

ENSP00000312326, ENST00000308423

Conserved Domains (3) summary

pfam02727
Location:66 – 152
Blast Score: 266

Cu_amine_oxidN2; Copper amine oxidase, N2 domain

pfam01179
Location:313 – 724
Blast Score: 1210

Cu_amine_oxid; Copper amine oxidase, enzyme domain

pfam02728
Location:169 – 269
Blast Score: 246

Cu_amine_oxidN3; Copper amine oxidase, N3 domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

41003201..41010141

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

36767841..36774781

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB050502.2	BAB18866.1
genomic	AC016889.28 (116794..123734)	None
genomic	CH471152.1	EAW60897.1
genomic	DQ143944.1	AAZ38716.1
mRNA	AF054985.1	AAC09346.1
mRNA	AF067406.1	AAC25170.1
mRNA	AK025727.1	None
mRNA	AK315129.1	BAG37582.1
mRNA	BC036368.1	None
mRNA	BC050549.1	AAH50549.1
mRNA	U39447.1	AAC50919.1