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RNASET2 ribonuclease T2 [ Homo sapiens (human) ]

Gene ID: 8635, updated on 12-May-2016
Official Symbol
RNASET2provided by HGNC
Official Full Name
ribonuclease T2provided by HGNC
Primary source
HGNC:HGNC:21686
See related
Ensembl:ENSG00000026297 HPRD:10197; MIM:612944; Vega:OTTHUMG00000016009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNASE6PL; bA514O12.3
Summary
This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6q27
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (166929516..166956589, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (167342992..167370077, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A2 Neighboring gene insulin like growth factor 2 mRNA binding protein 3 pseudogene Neighboring gene RPS6KA2 antisense RNA 1 Neighboring gene protein GVQW1-like Neighboring gene uncharacterized LOC105378120 Neighboring gene uncharacterized LOC105378121

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Leukoencephalopathy, cystic, without megalencephaly
MedGen: C2751843 OMIM: 612951 GeneReviews: Not available
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NHGRI GWAS Catalog

Description
A genome-wide association study identifies two new risk loci for Graves' disease.
NHGRI GWA Catalog
Genome-wide association study for vitiligo identifies susceptibility loci at 6q27 and the MHC.
NHGRI GWA Catalog
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.
NHGRI GWA Catalog
Genome-wide association study of endometrial cancer in E2C2.
NHGRI GWA Catalog
Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ42372

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
ribonuclease T2 activity IEA
Inferred from Electronic Annotation
more info
 
ribonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 
lysosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ribonuclease T2
Names
ribonuclease 6
NP_003721.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016280.1 RefSeqGene

    Range
    5001..32074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003730.4NP_003721.2  ribonuclease T2 precursor

    See identical proteins and their annotated locations for NP_003721.2

    Status: REVIEWED

    Source sequence(s)
    AL133458, AL159163
    Consensus CDS
    CCDS5295.1
    UniProtKB/Swiss-Prot
    O00584
    Related
    ENSP00000426455, OTTHUMP00000017608, ENST00000508775, OTTHUMT00000043089
    Conserved Domains (1) summary
    cd01061
    Location:34227
    RNase_T2_euk; Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    166929516..166956589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    167605634..167632656 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)