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    CADPS Ca++-dependent secretion activator [ Homo sapiens ]

    Gene ID: 8618, updated on 11-May-2012
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    Summary

    Official Symbol
    CADPSprovided by HGNC
    Official Full Name
    Ca++-dependent secretion activatorprovided by HGNC
    Primary source
    HGNC:1426
    See related
    Ensembl:ENSG00000163618; HPRD:05236; MIM:604667; Vega:OTTHUMG00000158651
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CAPS; CAPS1; CADPS1; KIAA1121
    Summary
    This gene encodes a novel neural/endocrine-specific cytosolic and peripheral membrane protein required for the Ca2+-regulated exocytosis of secretory vesicles. The protein acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Alternative splicing has been observed at this locus and three variants, encoding distinct isoforms, are described. [provided by RefSeq, Aug 2008]
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    Genomic context

    Location :
    3p14.2
    Sequence :
    Chromosome: 3; NC_000003.11 (62384021..62861064, complement)
    See CADPS in Epigenomics, MapViewer

    Chromosome 3 - NC_000003.11Genomic Context describing neighboring genes Neighboring gene chromosome 3 open reading frame 14 Neighboring gene FEZ family zinc finger 2 Neighboring gene ribosomal protein L14 pseudogene 2 Neighboring gene ribosomal protein S10 pseudogene 10 Neighboring gene keratin 8 pseudogene 35

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma. Miller S, et al. Neuro Oncol, 2011 Aug. PMID 21798848.
    2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug. PMID 21697133.
    3. Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients. Hattori K, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2011 Aug 15. PMID 21601610.
    4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Increased level of CADPS protein, human in Schizophrenic patients
      Title: Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.
    2. Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
      Title: Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    6. Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).
      Title: Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS).
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9ULU8 Q9ULU8 CADPS    HPRD  PubMed  
    Q9ULU8 P11532 DMD    HPRD  PubMed  
    Q9ULU8 P14416 DRD2    HPRD  PubMed  
    Q9ULU8 Q9Y383 LUC7L2    HPRD  PubMed  
    Q9ULU8 Q99755 PIP5K1A    HPRD  PubMed  
    Q9ULU8 KIAA1549 protein     HPRD  PubMed  
    BioGRID:114174 BioGRID:121702 KIAA1549    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    catecholamine secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of calcium ion-dependent exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
    		  
    vesicle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    calcium-dependent secretion activator 1
    Names
    calcium-dependent secretion activator 1
    CAPS-1
    Ca2+-dependent secretion activator
    Ca2+-regulated cytoskeletal protein
    Ca2+-dependent activator protein for secretion
    calcium-dependent activator protein for secretion 1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003716.3 → NP_003707.2  calcium-dependent secretion activator 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS46858.1
      UniProtKB/Swiss-Prot
      Q9ULU8
      Related
      ENSP00000373215, OTTHUMP00000213351, ENST00000383710, OTTHUMT00000351951
      Conserved Domains (2) summary
      pfam06292
      Location:835 – 940
      Blast Score: 369
      DUF1041; Domain of Unknown Function (DUF1041)
      cl00273
      Location:521 – 630
      Blast Score: 592
      PH-like; Pleckstrin homology-like domain

    2. NM_183393.2 → NP_899630.1  calcium-dependent secretion activator 1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is the shortest isoform and lacks multiple internal regions, compared to isoform 1.
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS2898.1
      UniProtKB/Swiss-Prot
      Q9ULU8
      Related
      ENSP00000350632, OTTHUMP00000213348, ENST00000357948, OTTHUMT00000351944
      Conserved Domains (2) summary
      pfam06292
      Location:818 – 910
      Blast Score: 343
      DUF1041; Domain of Unknown Function (DUF1041)
      cl00273
      Location:521 – 630
      Blast Score: 592
      PH-like; Pleckstrin homology-like domain

    3. NM_183394.2 → NP_899631.1  calcium-dependent secretion activator 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than, and contains internal differences, compared to isoform 1.
      Source sequence(s)
      AC012519, AC092039, AC104161
      Consensus CDS
      CCDS2899.1
      UniProtKB/Swiss-Prot
      Q9ULU8
      Related
      ENSP00000283269, OTTHUMP00000213223, ENST00000283269, OTTHUMT00000351642
      Conserved Domains (2) summary
      pfam06292
      Location:835 – 950
      Blast Score: 329
      DUF1041; Domain of Unknown Function (DUF1041)
      cl00273
      Location:521 – 630
      Blast Score: 593
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000003.11 Reference GRCh37.p5 Primary Assembly

      Range
      62384021..62861064, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000135.1 Alternate HuRef

      Range
      62482129..62959100, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC012519.9 (3311..161713) None
    genomic AC092039.2 (36073..166559) None
    genomic AC104161.2 (16400..166658) None
    genomic AC124860.2 (1454..39349) None
    genomic CH471055.1 EAW65405.1
      EAW65406.1
      EAW65407.1
      EAW65408.1
      EAW65409.1
      EAW65410.1
      EAW65411.1
    mRNA AB032947.2 BAA86435.2
    mRNA AB593079.1 BAJ84019.1
    mRNA AF458662.1 AAM61861.1
    mRNA AK000873.1 None
    mRNA AK127506.1 None
    mRNA AL833895.1 CAD38751.1
    mRNA BC015754.1 AAH15754.1
    mRNA BC029460.1 AAH29460.1
    mRNA BC035100.1 None
    mRNA BC072684.1 AAH72684.1
    mRNA BC131731.1 AAI31732.1
    mRNA BX647166.1 None
    mRNA R54020.1 None
    mRNA U36448.1 AAA79701.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ULU8.3 GenPept UniProtKB/Swiss-Prot:Q9ULU8
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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