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RDH16 retinol dehydrogenase 16 (all-trans) [ Homo sapiens (human) ]

Gene ID: 8608, updated on 15-Feb-2015
Official Symbol
RDH16provided by HGNC
Official Full Name
retinol dehydrogenase 16 (all-trans)provided by HGNC
Primary source
HGNC:HGNC:29674
See related
HPRD:10208
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RODH-4; SDR9C8
Orthologs
See RDH16 in MapViewer
Location:
12q13.3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (56951431..56959374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57345215..57353158, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene short chain dehydrogenase/reductase family 9C, member 7 Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene G protein-coupled receptor 182

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with visual transduction, organism-specific biosystem (from REACTOME)
    Diseases associated with visual transduction, organism-specific biosystemThe process of vision involves two stages; the retinoid cycle which supplies and regenerates the visual chromophore required for vision and phototransduction which propagates the light signal. Defect...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • RA biosynthesis pathway, organism-specific biosystem (from REACTOME)
    RA biosynthesis pathway, organism-specific biosystemThe major activated retinoid, all-trans-retinoic acid (atRA) is produced by the dehydrogenation of all-trans-retinol (atROL) by members of the short chain dehydrogenase/reductase (SDR) and aldehyde d...
  • Retinol metabolism, organism-specific biosystem (from KEGG)
    Retinol metabolism, organism-specific biosystem
    Retinol metabolism
  • Retinol metabolism, conserved biosystem (from KEGG)
    Retinol metabolism, conserved biosystem
    Retinol metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
    Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
  • The canonical retinoid cycle in rods (twilight vision), organism-specific biosystem (from REACTOME)
    The canonical retinoid cycle in rods (twilight vision), organism-specific biosystemThe retinoid cycle (also referred to as the visual cycle) is the process by which the visual chromophore 11-cis-retinal (11cRAL) is released from light-activated opsins in the form all-trans-retinal ...
  • Visual phototransduction, organism-specific biosystem (from REACTOME)
    Visual phototransduction, organism-specific biosystemVisual phototransduction is the process by which photon absorption by visual pigment molecules in photoreceptor cells is converted to an electrical cellular response. The events in this process are p...
  • retinoate biosynthesis I, conserved biosystem (from BIOCYC)
    retinoate biosynthesis I, conserved biosystemGeneral Background |FRAME: RETINOATE "All-trans retinoic acid"|, one of the forms of vitamin A, is a metabolite of |FRAME: CPD-13524| that mediates the functions of vitamin A required for growth and...
  • retinoate biosynthesis I, organism-specific biosystem (from BIOCYC)
    retinoate biosynthesis I, organism-specific biosystem
    retinoate biosynthesis I

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
electron carrier activity TAS
Traceable Author Statement
more info
PubMed 
retinol dehydrogenase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
retinol dehydrogenase 16
Names
retinol dehydrogenase 16
microsomal NAD(+)-dependent retinol dehydrogenase 4
microsomal NAD+-dependent retinol dehydrogenase 4
retinol dehydrogenase 16 (all-trans and 13-cis)
short chain dehydrogenase/reductase family 9C, member 8
sterol/retinol dehydrogenase

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003708.3NP_003699.3  retinol dehydrogenase 16

    See proteins identical to NP_003699.3

    Status: VALIDATED

    Source sequence(s)
    AC026120, AF057034, AW449664
    Consensus CDS
    CCDS41797.1
    UniProtKB/Swiss-Prot
    O75452
    Conserved Domains (2) summary
    PRK06179
    Location:30304
    PRK06179; short chain dehydrogenase; Provisional
    cl21454
    Location:30305
    SDR; Short-chain dehydrogenases/reductases (SDR)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38 Primary Assembly

    Range
    56951431..56959374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269205.1XP_005269262.1  

    Conserved Domains (1) summary
    cl21454
    Location:46160
    SDR; Short-chain dehydrogenases/reductases (SDR)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    57312965..57319168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000144.1 Alternate HuRef

    Range
    54383970..54390173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)